YPL248C / GAL4

DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL248C / GAL4

Click on Significant Values for Screen Details ID:SGTC_391|Compound:gliotoxin|FD-Score:3.74|P-value:3.79E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.08|P-value:5.69E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.06|P-value:6.01E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.07|P-value:6.26E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.66|P-value:5.43E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.19|P-value:3.93E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.20|P-value:2.91E-11 ID:SGTC_684|Compound:1140-0066|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.76|P-value:3.50E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:4.34|P-value:2.20E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.87|P-value:2.29E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.17|P-value:4.06E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.50|P-value:1.06E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.57|P-value:6.84E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.27|P-value:2.74E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.58|P-value:7.14E-7 ID:SGTC_1387|Compound:3342-1166|FD-Score:-7.09|P-value:3.80E-14 ID:SGTC_1389|Compound:3405-0187|FD-Score:-5.21|P-value:2.08E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.72|P-value:3.10E-7 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.24|P-value:3.20E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.36|P-value:1.87E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.02|P-value:6.88E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.15|P-value:4.51E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.35|P-value:2.32E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.14|P-value:5.97E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.02|P-value:7.49E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.40|P-value:1.63E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.26|P-value:3.42E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.28|P-value:2.59E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.64|P-value:6.01E-5 ID:SGTC_1732|Compound:st034308|FD-Score:2.93|P-value:9.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.36|P-value:2.01E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.67|P-value:5.60E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.05|P-value:9.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.98|P-value:8.70E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.95|P-value:1.51E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.28|P-value:2.64E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-5.14|P-value:3.14E-8 ID:SGTC_2938|Compound:9059746|FD-Score:2.95|P-value:9.09E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.88|P-value:2.22E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.32|P-value:2.46E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.85|P-value:2.38E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.89|P-value:1.97E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_3242|Compound:9133940|FD-Score:5.00|P-value:6.13E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.74|P-value:3.79E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.08|P-value:5.69E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.06|P-value:6.01E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.07|P-value:6.26E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.66|P-value:5.43E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.19|P-value:3.93E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.20|P-value:2.91E-11 ID:SGTC_684|Compound:1140-0066|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.76|P-value:3.50E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:4.34|P-value:2.20E-6 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.87|P-value:2.29E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.17|P-value:4.06E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.50|P-value:1.06E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.57|P-value:6.84E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.27|P-value:2.74E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.58|P-value:7.14E-7 ID:SGTC_1387|Compound:3342-1166|FD-Score:-7.09|P-value:3.80E-14 ID:SGTC_1389|Compound:3405-0187|FD-Score:-5.21|P-value:2.08E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.72|P-value:3.10E-7 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.24|P-value:3.20E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.36|P-value:1.87E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.02|P-value:6.88E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.15|P-value:4.51E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.35|P-value:2.32E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.14|P-value:5.97E-6 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.02|P-value:7.49E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.40|P-value:1.63E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.26|P-value:3.42E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.28|P-value:2.59E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.64|P-value:6.01E-5 ID:SGTC_1732|Compound:st034308|FD-Score:2.93|P-value:9.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.36|P-value:2.01E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:2.95|P-value:9.14E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.67|P-value:5.60E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.05|P-value:9.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.98|P-value:8.70E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.95|P-value:1.51E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.28|P-value:2.64E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.90|P-value:1.98E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-5.14|P-value:3.14E-8 ID:SGTC_2938|Compound:9059746|FD-Score:2.95|P-value:9.09E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.88|P-value:2.22E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.32|P-value:2.46E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.85|P-value:2.38E-5 ID:SGTC_3075|Compound:9116269|FD-Score:3.89|P-value:1.97E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_3242|Compound:9133940|FD-Score:5.00|P-value:6.13E-8

Top fitness defect scores for YPL248C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_676 falcarinol 6.20 140.0 µM 2.91E-11 12 2.87E-10
2 SGTC_3242 9133940 5.00 49.5 µM 6.13E-8 1 2.80E-7
3 SGTC_1391 3442-0225 4.72 151.0 µM 3.10E-7 4 1.20E-6
4 SGTC_1136 pergolide 4.57 1.1 µM 6.84E-7 23 2.45E-6
5 SGTC_721 1187-1332 4.34 279.0 µM 2.20E-6 cell wall signaling 12 7.04E-6
6 SGTC_2954 9074818 4.32 52.7 µM 2.46E-6 28 7.75E-6
7 SGTC_1672 st016598 4.26 6.5 µM 3.42E-6 endomembrane recycling 57 1.04E-5
8 SGTC_1525 8-methoxypsoralen 4.14 92.5 µM 5.97E-6 DNA damage response 25 1.73E-5
9 SGTC_2121 5257820 4.05 149.6 µM 9.25E-6 10 2.56E-5
10 SGTC_2313 7726885 3.95 200.0 µM 1.51E-5 RPP1 & pyrimidine depletion 33 3.98E-5
11 SGTC_3075 9116269 3.89 49.5 µM 1.97E-5 22 5.07E-5
12 SGTC_3059 1327-0034 3.85 3.0 µM 2.38E-5 55 5.99E-5
13 SGTC_718 1130-0073 3.76 349.0 µM 3.50E-5 26 8.50E-5
14 SGTC_391 gliotoxin 3.74 8.3 µM 3.79E-5 72 9.12E-5
15 SGTC_600 1495-0418 3.66 41.6 µM 5.43E-5 RPP1 & pyrimidine depletion 16 1.26E-4
16 SGTC_1727 st034309 3.64 9.9 µM 6.01E-5 57 1.38E-4
17 SGTC_1126 isoteolin 3.50 1.0 µM 1.06E-4 47 2.30E-4
18 SGTC_684 1140-0066 3.47 328.0 µM 1.19E-4 Golgi 47 2.56E-4
19 SGTC_1618 st003135 3.40 44.5 µM 1.63E-4 31 3.41E-4
20 SGTC_1397 3532-0190 3.36 20.1 µM 1.87E-4 15 3.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.82E-17 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.144 5.78E-17 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.142 1.70E-16 YDL036C PUS9 hom Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.134 6.73E-15 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.130 3.46E-14 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.125 4.17E-13 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.122 1.28E-12 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.122 1.71E-12 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.116 1.49E-11 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.116 1.80E-11 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.116 2.03E-11 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.112 8.39E-11 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.111 9.85E-11 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.110 1.41E-10 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.110 1.65E-10 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress