HIPHOP chemogenomics database

YPL248C / GAL4

DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL248C / GAL4

Click on Significant Values for Screen Details

Top fitness defect scores for YPL248C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_676	falcarinol	6.20	140.0 µM	2.91E-11		12	2.87E-10
2	SGTC_3242	9133940	5.00	49.5 µM	6.13E-8		1	2.80E-7
3	SGTC_1391	3442-0225	4.72	151.0 µM	3.10E-7		4	1.20E-6
4	SGTC_1136	pergolide	4.57	1.1 µM	6.84E-7		23	2.45E-6
5	SGTC_721	1187-1332	4.34	279.0 µM	2.20E-6	cell wall signaling	12	7.04E-6
6	SGTC_2954	9074818	4.32	52.7 µM	2.46E-6		28	7.75E-6
7	SGTC_1672	st016598	4.26	6.5 µM	3.42E-6	endomembrane recycling	57	1.04E-5
8	SGTC_1525	8-methoxypsoralen	4.14	92.5 µM	5.97E-6	DNA damage response	25	1.73E-5
9	SGTC_2121	5257820	4.05	149.6 µM	9.25E-6		10	2.56E-5
10	SGTC_2313	7726885	3.95	200.0 µM	1.51E-5	RPP1 & pyrimidine depletion	33	3.98E-5
11	SGTC_3075	9116269	3.89	49.5 µM	1.97E-5		22	5.07E-5
12	SGTC_3059	1327-0034	3.85	3.0 µM	2.38E-5		55	5.99E-5
13	SGTC_718	1130-0073	3.76	349.0 µM	3.50E-5		26	8.50E-5
14	SGTC_391	gliotoxin	3.74	8.3 µM	3.79E-5		72	9.12E-5
15	SGTC_600	1495-0418	3.66	41.6 µM	5.43E-5	RPP1 & pyrimidine depletion	16	1.26E-4
16	SGTC_1727	st034309	3.64	9.9 µM	6.01E-5		57	1.38E-4
17	SGTC_1126	isoteolin	3.50	1.0 µM	1.06E-4		47	2.30E-4
18	SGTC_684	1140-0066	3.47	328.0 µM	1.19E-4	Golgi	47	2.56E-4
19	SGTC_1618	st003135	3.40	44.5 µM	1.63E-4		31	3.41E-4
20	SGTC_1397	3532-0190	3.36	20.1 µM	1.87E-4		15	3.85E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.145	2.82E-17	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.144	5.78E-17	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.142	1.70E-16	YDL036C	PUS9	hom	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.134	6.73E-15	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.130	3.46E-14	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.125	4.17E-13	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.122	1.28E-12	YMR137C	PSO2	hom	Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.122	1.71E-12	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.116	1.49E-11	YKL185W	ASH1	hom	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.116	1.80E-11	YDR117C	TMA64	hom	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.116	2.03E-11	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.112	8.39E-11	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.111	9.85E-11	YDR169C	STB3	hom	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.110	1.41E-10	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.110	1.65E-10	YGR136W	LSB1	hom	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress