YPL249C / GYP5

GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL249C / GYP5

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.19|P-value:3.44E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.01|P-value:6.35E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.23|P-value:2.73E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.96|P-value:8.09E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:2.91|P-value:9.41E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.15|P-value:1.84E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:3.11|P-value:4.40E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.62|P-value:4.17E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-4.01|P-value:9.75E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.11|P-value:4.43E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-2.92|P-value:9.42E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.03|P-value:6.34E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.41|P-value:1.35E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.19|P-value:3.28E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.56|P-value:6.94E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.82|P-value:2.27E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.41|P-value:1.38E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.73|P-value:3.52E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.72|P-value:3.68E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.88|P-value:1.01E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.96|P-value:1.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.84|P-value:2.10E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.51|P-value:9.25E-5 ID:SGTC_2108|Compound:5365811|FD-Score:-3.67|P-value:4.56E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.10|P-value:4.52E-4 ID:SGTC_2394|Compound:5221648|FD-Score:5.89|P-value:1.61E-10 ID:SGTC_2404|Compound:5161160|FD-Score:8.27|P-value:5.13E-19 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:8.32|P-value:3.26E-19 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-6.47|P-value:2.56E-12 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:5.02|P-value:4.16E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-5.24|P-value:1.19E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-2.92|P-value:9.37E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.93|P-value:8.56E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.32|P-value:1.99E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.69|P-value:4.29E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.31|P-value:2.04E-6 ID:SGTC_2915|Compound:7971052|FD-Score:-3.07|P-value:5.32E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.08|P-value:6.59E-6 ID:SGTC_2941|Compound:9056145|FD-Score:3.62|P-value:5.40E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.99|P-value:6.83E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.19|P-value:3.44E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.01|P-value:6.35E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.23|P-value:2.73E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.96|P-value:8.09E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:2.91|P-value:9.41E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.15|P-value:1.84E-8 ID:SGTC_669|Compound:0108-0021|FD-Score:3.11|P-value:4.40E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.62|P-value:4.17E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-4.01|P-value:9.75E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.11|P-value:4.43E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-2.92|P-value:9.42E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.03|P-value:6.34E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.41|P-value:1.35E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.19|P-value:3.28E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.56|P-value:6.94E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.82|P-value:2.27E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.41|P-value:1.38E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.73|P-value:3.52E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.72|P-value:3.68E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.88|P-value:1.01E-7 ID:SGTC_1741|Compound:st038134|FD-Score:3.96|P-value:1.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.84|P-value:2.10E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.51|P-value:9.25E-5 ID:SGTC_2108|Compound:5365811|FD-Score:-3.67|P-value:4.56E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.10|P-value:4.52E-4 ID:SGTC_2394|Compound:5221648|FD-Score:5.89|P-value:1.61E-10 ID:SGTC_2404|Compound:5161160|FD-Score:8.27|P-value:5.13E-19 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:8.32|P-value:3.26E-19 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-6.47|P-value:2.56E-12 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:5.02|P-value:4.16E-8 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-5.24|P-value:1.19E-8 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-2.92|P-value:9.37E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_2706|Compound:st078239|FD-Score:2.93|P-value:8.56E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.32|P-value:1.99E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.69|P-value:4.29E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.31|P-value:2.04E-6 ID:SGTC_2915|Compound:7971052|FD-Score:-3.07|P-value:5.32E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.08|P-value:6.59E-6 ID:SGTC_2941|Compound:9056145|FD-Score:3.62|P-value:5.40E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_3080|Compound:9117754|FD-Score:2.99|P-value:6.83E-4

Top fitness defect scores for YPL249C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 8.32 100.0 µM 3.26E-19 1 4.49E-17
2 SGTC_2404 5161160 8.27 200.0 µM 5.13E-19 1 6.69E-17
3 SGTC_2394 5221648 5.89 200.0 µM 1.61E-10 5 1.98E-9
4 SGTC_536 3852-0578 5.15 10.6 µM 1.84E-8 8 1.28E-7
5 SGTC_2559 tetrahydrosappanone a trimethyl ether 5.02 100.0 µM 4.16E-8 2 2.63E-7
6 SGTC_2909 7941780 4.31 10.5 µM 2.04E-6 13 8.12E-6
7 SGTC_2917 7979103 4.08 53.8 µM 6.59E-6 26 2.29E-5
8 SGTC_1741 st038134 3.96 10.2 µM 1.18E-5 32 3.82E-5
9 SGTC_1439 4092-1168 3.82 46.0 µM 2.27E-5 11 6.81E-5
10 SGTC_2941 9056145 3.62 11.2 µM 5.40E-5 24 1.46E-4
11 SGTC_1193 1488-0126 3.56 41.5 µM 6.94E-5 37 1.82E-4
12 SGTC_1423 4048-0112 3.46 5.6 µM 1.09E-4 38 2.73E-4
13 SGTC_1125 tnp00248 3.41 1.3 µM 1.35E-4 60 3.29E-4
14 SGTC_2944 9067346 3.26 25.6 µM 2.41E-4 55 5.48E-4
15 SGTC_260 nsc-65238 3.23 4.0 µM 2.73E-4 endomembrane recycling 35 6.12E-4
16 SGTC_1127 asiatic acid 3.19 681.4 nM 3.28E-4 54 7.20E-4
17 SGTC_669 0108-0021 3.11 26.2 µM 4.40E-4 fatty acid desaturase (OLE1) 145 9.34E-4
18 SGTC_936 3005-4620 3.11 401.0 µM 4.43E-4 66 9.39E-4
19 SGTC_2287 7945887 3.10 168.8 µM 4.52E-4 31 9.57E-4
20 SGTC_2703 st077852 3.07 53.4 µM 5.05E-4 62 0.00105

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 9.94E-31 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.186 1.72E-27 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.162 5.37E-21 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.160 1.66E-20 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.153 4.76E-19 YGR066C_p YGR066C_p hom Putative protein of unknown function
0.142 1.68E-16 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.136 3.24E-15 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.133 1.13E-14 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.128 1.26E-13 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.123 9.93E-13 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.122 1.12E-12 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.120 2.92E-12 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.117 1.06E-11 YML003W_p YML003W_p hom Putative protein of unknown function
0.116 1.75E-11 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.116 1.83E-11 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins