YPL249C-A / RPL36B

Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL249C-A / RPL36B

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:2.96|P-value:7.99E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:3.17E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:2.99|P-value:6.98E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:2.91|P-value:9.51E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.17|P-value:3.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.57|P-value:1.87E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.26|P-value:6.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.35|P-value:6.62E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.31|P-value:1.26E-8 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.67|P-value:4.39E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:2.91|P-value:9.25E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.05|P-value:9.22E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:5.45|P-value:5.37E-9 ID:SGTC_791|Compound:1348-1292|FD-Score:2.98|P-value:7.45E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.90|P-value:3.11E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:5.47|P-value:4.57E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:5.22|P-value:2.06E-8 ID:SGTC_904|Compound:1141-0088|FD-Score:3.68|P-value:4.72E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.62|P-value:7.71E-9 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.55|P-value:2.09E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.24|P-value:3.74E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-8.22|P-value:3.93E-17 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.63|P-value:5.34E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.14|P-value:6.02E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.10|P-value:4.82E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.70|P-value:3.67E-7 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.16|P-value:8.78E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.18|P-value:3.60E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:2.97|P-value:7.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.05|P-value:9.38E-6 ID:SGTC_1659|Compound:st012954|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.26|P-value:9.97E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.30|P-value:5.24E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.52|P-value:9.20E-5 ID:SGTC_1921|Compound:5740136|FD-Score:3.78|P-value:3.13E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.59|P-value:7.03E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-5.61|P-value:7.90E-9 ID:SGTC_1990|Compound:st072050|FD-Score:3.66|P-value:5.17E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.01|P-value:6.48E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.77|P-value:8.42E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.69|P-value:4.59E-5 ID:SGTC_2314|Compound:7727897|FD-Score:2.95|P-value:8.14E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.16|P-value:3.00E-8 ID:SGTC_2376|Compound:9072922|FD-Score:3.51|P-value:9.71E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.50|P-value:2.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.93|P-value:1.09E-7 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.06|P-value:5.61E-4 ID:SGTC_2803|Compound:7707263|FD-Score:2.92|P-value:9.06E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.93|P-value:4.44E-5 ID:SGTC_2937|Compound:9044753|FD-Score:4.50|P-value:1.03E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.39|P-value:1.58E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.59|P-value:7.01E-5 ID:SGTC_3116|Compound:9124943|FD-Score:-3.41|P-value:3.56E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.09|P-value:4.99E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.38|P-value:3.90E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-4.28|P-value:8.99E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.97|P-value:1.34E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.77|P-value:3.19E-5 ID:SGTC_33|Compound:0986-0033|FD-Score:2.96|P-value:7.99E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.78|P-value:3.17E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:2.99|P-value:6.98E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:2.91|P-value:9.51E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.17|P-value:3.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.57|P-value:1.87E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.26|P-value:6.16E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.35|P-value:6.62E-6 ID:SGTC_422|Compound:cantharidin|FD-Score:5.31|P-value:1.26E-8 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.67|P-value:4.39E-7 ID:SGTC_556|Compound:4058-0063|FD-Score:2.91|P-value:9.25E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.05|P-value:9.22E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:5.45|P-value:5.37E-9 ID:SGTC_791|Compound:1348-1292|FD-Score:2.98|P-value:7.45E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.90|P-value:3.11E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:5.47|P-value:4.57E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:5.22|P-value:2.06E-8 ID:SGTC_904|Compound:1141-0088|FD-Score:3.68|P-value:4.72E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-5.62|P-value:7.71E-9 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.55|P-value:2.09E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.24|P-value:3.74E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-8.22|P-value:3.93E-17 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.63|P-value:5.34E-7 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.02|P-value:6.35E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.14|P-value:6.02E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.10|P-value:4.82E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.70|P-value:3.67E-7 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.16|P-value:8.78E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.18|P-value:3.60E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.90|P-value:9.82E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:2.97|P-value:7.61E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.05|P-value:9.38E-6 ID:SGTC_1659|Compound:st012954|FD-Score:3.15|P-value:3.91E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.26|P-value:9.97E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.30|P-value:5.24E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.52|P-value:9.20E-5 ID:SGTC_1921|Compound:5740136|FD-Score:3.78|P-value:3.13E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.59|P-value:7.03E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-5.61|P-value:7.90E-9 ID:SGTC_1990|Compound:st072050|FD-Score:3.66|P-value:5.17E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.01|P-value:6.48E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.77|P-value:8.42E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.69|P-value:4.59E-5 ID:SGTC_2314|Compound:7727897|FD-Score:2.95|P-value:8.14E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.16|P-value:3.00E-8 ID:SGTC_2376|Compound:9072922|FD-Score:3.51|P-value:9.71E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.50|P-value:2.53E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.93|P-value:1.09E-7 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.38|P-value:1.61E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.06|P-value:5.61E-4 ID:SGTC_2803|Compound:7707263|FD-Score:2.92|P-value:9.06E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-3.93|P-value:4.44E-5 ID:SGTC_2937|Compound:9044753|FD-Score:4.50|P-value:1.03E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.39|P-value:1.58E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.59|P-value:7.01E-5 ID:SGTC_3116|Compound:9124943|FD-Score:-3.41|P-value:3.56E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.09|P-value:4.99E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.38|P-value:3.90E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-4.28|P-value:8.99E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.97|P-value:1.34E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.77|P-value:3.19E-5

Top fitness defect scores for YPL249C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 5.90 155.0 µM 3.11E-10 translation 53 1.80E-9
2 SGTC_830 4076-0286 5.47 57.8 µM 4.57E-9 translation 23 2.19E-8
3 SGTC_741 4582-0002 5.45 126.0 µM 5.37E-9 3 2.55E-8
4 SGTC_422 cantharidin 5.31 155.0 µM 1.26E-8 cell wall signaling 27 5.62E-8
5 SGTC_832 4083-0019 5.22 164.0 µM 2.06E-8 translation 33 8.87E-8
6 SGTC_2344 7990960 5.16 77.0 µM 3.00E-8 12 1.26E-7
7 SGTC_2688 kanamycin b 4.93 96.7 µM 1.09E-7 calcium & mitochondrial duress 251 4.17E-7
8 SGTC_1383 3049-0032 4.70 20.7 µM 3.67E-7 60S ribosome export 9 1.28E-6
9 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.67 6.7 µM 4.39E-7 5 1.52E-6
10 SGTC_1186 1319-0216 4.63 26.0 µM 5.34E-7 10 1.82E-6
11 SGTC_2937 9044753 4.50 11.3 µM 1.03E-6 60S ribosome export 22 3.35E-6
12 SGTC_1021 4476-0760 4.24 85.3 µM 3.74E-6 16 1.10E-5
13 SGTC_1327 1436-0082 4.14 2.2 µM 6.02E-6 16 1.71E-5
14 SGTC_659 k018-0002 4.05 107.0 µM 9.22E-6 14 2.54E-5
15 SGTC_1619 st003326 4.05 88.7 µM 9.38E-6 60S ribosome export 17 2.58E-5
16 SGTC_3232 9132874 3.97 49.5 µM 1.34E-5 RPP1 & pyrimidine depletion 12 3.58E-5
17 SGTC_2940 9060638 3.81 45.9 µM 2.72E-5 amide catabolism 31 6.90E-5
18 SGTC_1921 5740136 3.78 50.0 µM 3.13E-5 TRP & mitochondrial translation 67 7.86E-5
19 SGTC_118 0083-0097 3.78 135.3 µM 3.17E-5 translation 155 7.95E-5
20 SGTC_3286 9117135 3.77 37.2 µM 3.19E-5 16 8.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.37E-38 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.219 8.57E-38 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.206 1.28E-33 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.178 2.61E-25 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.172 1.21E-23 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.164 1.57E-21 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.160 1.05E-20 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.152 7.07E-19 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.150 2.06E-18 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.150 2.23E-18 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.148 7.23E-18 YNL248C RPA49 hom RNA polymerase I subunit A49
0.147 8.70E-18 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.146 1.83E-17 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.145 2.97E-17 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.144 4.74E-17 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin