YPL250C / ICY2

Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL250C / ICY2

Click on Significant Values for Screen Details ID:SGTC_353|Compound:1988-1175|FD-Score:3.31|P-value:6.93E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.52|P-value:3.30E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.45|P-value:4.26E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.03|P-value:2.41E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.23|P-value:5.29E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.41|P-value:4.87E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.59|P-value:2.58E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.56|P-value:4.48E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:3.38|P-value:5.47E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-3.40|P-value:2.92E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.00|P-value:5.25E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.36|P-value:1.14E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.20|P-value:2.27E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.27|P-value:7.77E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.26|P-value:8.29E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.52|P-value:3.23E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.40|P-value:9.39E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.45|P-value:4.27E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.52|P-value:1.89E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.41|P-value:4.86E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:1.00E-4 ID:SGTC_2015|Compound:5119600|FD-Score:8.46|P-value:5.30E-17 ID:SGTC_2017|Compound:5132927|FD-Score:4.04|P-value:4.48E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.50|P-value:3.51E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.21|P-value:9.54E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.35|P-value:3.54E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.27|P-value:7.91E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.38|P-value:5.50E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.70|P-value:1.66E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.13|P-value:2.89E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.68|P-value:1.82E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.80|P-value:1.48E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.28|P-value:1.62E-5 ID:SGTC_2954|Compound:9074818|FD-Score:7.17|P-value:1.11E-12 ID:SGTC_2957|Compound:9076800|FD-Score:-3.22|P-value:5.52E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.64|P-value:3.15E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.24|P-value:8.79E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.21|P-value:9.68E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.57|P-value:4.30E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.11|P-value:3.34E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.77|P-value:1.30E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-3.16|P-value:6.70E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.03|P-value:2.41E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.36|P-value:5.70E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.47|P-value:3.86E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.31|P-value:6.93E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.64|P-value:2.07E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.52|P-value:3.30E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.45|P-value:4.26E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:-4.03|P-value:2.41E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.23|P-value:5.29E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.41|P-value:4.87E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.59|P-value:2.58E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.56|P-value:4.48E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:3.38|P-value:5.47E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-3.40|P-value:2.92E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.00|P-value:5.25E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.50|P-value:3.50E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.36|P-value:1.14E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.20|P-value:2.27E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.17|P-value:2.51E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.27|P-value:7.77E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.26|P-value:8.29E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.52|P-value:3.23E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.29|P-value:4.25E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.40|P-value:9.39E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.45|P-value:4.27E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.52|P-value:1.89E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.41|P-value:4.86E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:1.00E-4 ID:SGTC_2015|Compound:5119600|FD-Score:8.46|P-value:5.30E-17 ID:SGTC_2017|Compound:5132927|FD-Score:4.04|P-value:4.48E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.50|P-value:3.51E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.21|P-value:9.54E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.56|P-value:2.87E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.35|P-value:3.54E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.27|P-value:7.91E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.38|P-value:5.50E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.25|P-value:8.39E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.70|P-value:1.66E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.13|P-value:2.89E-7 ID:SGTC_2807|Compound:7945238|FD-Score:3.68|P-value:1.82E-4 ID:SGTC_2862|Compound:9027634|FD-Score:4.80|P-value:1.48E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.28|P-value:1.62E-5 ID:SGTC_2954|Compound:9074818|FD-Score:7.17|P-value:1.11E-12 ID:SGTC_2957|Compound:9076800|FD-Score:-3.22|P-value:5.52E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.64|P-value:3.15E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.24|P-value:8.79E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.21|P-value:9.68E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.57|P-value:4.30E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.11|P-value:3.34E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.77|P-value:1.30E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-3.16|P-value:6.70E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.03|P-value:2.41E-5 ID:SGTC_3182|Compound:9108849|FD-Score:3.36|P-value:5.70E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.47|P-value:3.86E-4

Top fitness defect scores for YPL250C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2015 5119600 8.46 184.0 µM 5.30E-17 3 1.31E-17
2 SGTC_2954 9074818 7.17 52.7 µM 1.11E-12 7 3.71E-13
3 SGTC_2797 7859098 5.13 81.8 µM 2.89E-7 9 1.47E-7
4 SGTC_2862 9027634 4.80 71.4 µM 1.48E-6 ERG2 17 7.95E-7
5 SGTC_3106 9121286 4.64 49.5 µM 3.15E-6 5 1.73E-6
6 SGTC_3129 9127257 4.57 49.5 µM 4.30E-6 13 2.40E-6
7 SGTC_976 1348-1067 4.56 47.6 µM 4.48E-6 60S ribosome export 16 2.51E-6
8 SGTC_1824 st053723 4.40 68.6 µM 9.39E-6 21 5.39E-6
9 SGTC_1472 k841-0093 4.36 193.0 µM 1.14E-5 11 6.57E-6
10 SGTC_2873 9040596 4.28 71.4 µM 1.62E-5 37 9.48E-6
11 SGTC_1531 st059297 4.20 52.4 µM 2.27E-5 10 1.35E-5
12 SGTC_954 1189-0853 4.18 2.9 µM 2.45E-5 endomembrane recycling 34 1.46E-5
13 SGTC_1691 st019933 4.17 84.6 µM 2.51E-5 10 1.50E-5
14 SGTC_3130 9127414 4.11 49.5 µM 3.34E-5 19 2.01E-5
15 SGTC_2017 5132927 4.04 60.6 µM 4.48E-5 31 2.72E-5
16 SGTC_1214 0358-0031 4.00 63.7 µM 5.25E-5 17 3.22E-5
17 SGTC_3138 9097216 3.77 49.5 µM 1.30E-4 18 8.22E-5
18 SGTC_2504 purpurogallin 3.71 52.3 µM 1.61E-4 RPP1 & pyrimidine depletion 26 1.03E-4
19 SGTC_797 k781-0471 3.71 270.0 µM 1.63E-4 RPP1 & pyrimidine depletion 30 1.04E-4
20 SGTC_2663 amphotericin b 3.70 100.0 µM 1.66E-4 14 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 2.03E-8 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.096 2.26E-8 YBR137W YBR137W hom Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene
0.093 6.24E-8 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.093 6.41E-8 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
0.086 5.57E-7 YNR059W MNT4 hom Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
0.085 8.76E-7 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.085 9.33E-7 YMR103C_d YMR103C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.20E-6 YMR242W-A_p YMR242W-A_p hom Putative protein of unknown function
0.083 1.41E-6 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.083 1.61E-6 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
0.082 1.96E-6 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.082 2.15E-6 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.082 2.17E-6 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.081 2.92E-6 YHR200W RPN10 hom Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
0.079 4.99E-6 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication