YPL251W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL251W / YPL251W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:5.00|P-value:2.44E-8 ID:SGTC_3|Compound:0833-0587|FD-Score:6.87|P-value:3.79E-14 ID:SGTC_4|Compound:0960-0234|FD-Score:5.41|P-value:1.80E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.77|P-value:1.96E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.03|P-value:4.56E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.57|P-value:5.90E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.99|P-value:8.46E-6 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.12|P-value:4.40E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.36|P-value:1.19E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:2.98|P-value:5.49E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:2.13E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.58|P-value:6.05E-10 ID:SGTC_576|Compound:1073-0113|FD-Score:7.50|P-value:1.57E-16 ID:SGTC_704|Compound:1310-0270|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.11|P-value:3.67E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.26|P-value:1.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.99|P-value:5.39E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.56|P-value:3.27E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.89|P-value:9.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:49.90|P-value:0 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.02|P-value:5.73E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-5.11|P-value:1.70E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.01|P-value:2.31E-8 ID:SGTC_1604|Compound:st002052|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.48|P-value:7.30E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:11.70|P-value:1.32E-37 ID:SGTC_1725|Compound:st036284|FD-Score:4.50|P-value:4.60E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-3.41|P-value:1.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.23|P-value:2.08E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.09|P-value:3.67E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.18|P-value:2.56E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.35|P-value:1.54E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.47|P-value:9.28E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.30|P-value:1.57E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.85|P-value:9.03E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.88|P-value:9.68E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.05|P-value:2.95E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.32|P-value:1.53E-6 ID:SGTC_2693|Compound:st077581|FD-Score:4.27|P-value:1.55E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.04|P-value:4.43E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.43|P-value:8.79E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.19|P-value:2.44E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.04|P-value:5.39E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.70|P-value:1.45E-7 ID:SGTC_3202|Compound:9113761|FD-Score:4.07|P-value:4.53E-6 ID:SGTC_3215|Compound:9129942|FD-Score:3.17|P-value:2.61E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.17|P-value:2.67E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:5.00|P-value:2.44E-8 ID:SGTC_3|Compound:0833-0587|FD-Score:6.87|P-value:3.79E-14 ID:SGTC_4|Compound:0960-0234|FD-Score:5.41|P-value:1.80E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:2.92|P-value:6.91E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.77|P-value:1.96E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.03|P-value:4.56E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.57|P-value:5.90E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.99|P-value:8.46E-6 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.12|P-value:4.40E-6 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.36|P-value:1.19E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:2.98|P-value:5.49E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:2.13E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.58|P-value:6.05E-10 ID:SGTC_576|Compound:1073-0113|FD-Score:7.50|P-value:1.57E-16 ID:SGTC_704|Compound:1310-0270|FD-Score:3.31|P-value:1.47E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.11|P-value:3.67E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.26|P-value:1.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.99|P-value:5.39E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.56|P-value:3.27E-7 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.89|P-value:9.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:49.90|P-value:0 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.02|P-value:5.73E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.33|P-value:1.39E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-5.11|P-value:1.70E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.08|P-value:3.80E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.01|P-value:2.31E-8 ID:SGTC_1604|Compound:st002052|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.48|P-value:7.30E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:11.70|P-value:1.32E-37 ID:SGTC_1725|Compound:st036284|FD-Score:4.50|P-value:4.60E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-3.41|P-value:1.20E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.23|P-value:2.08E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.09|P-value:3.67E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.18|P-value:2.56E-4 ID:SGTC_1995|Compound:st072814|FD-Score:-3.35|P-value:1.54E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.47|P-value:9.28E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.30|P-value:1.57E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.85|P-value:9.03E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.30|P-value:1.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.88|P-value:9.68E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-6.05|P-value:2.95E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.32|P-value:1.53E-6 ID:SGTC_2693|Compound:st077581|FD-Score:4.27|P-value:1.55E-6 ID:SGTC_2839|Compound:9003951|FD-Score:3.04|P-value:4.43E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.43|P-value:8.79E-5 ID:SGTC_2921|Compound:7974240|FD-Score:2.93|P-value:6.67E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.19|P-value:2.44E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.04|P-value:5.39E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.70|P-value:1.45E-7 ID:SGTC_3202|Compound:9113761|FD-Score:4.07|P-value:4.53E-6 ID:SGTC_3215|Compound:9129942|FD-Score:3.17|P-value:2.61E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.17|P-value:2.67E-4

Top fitness defect scores for YPL251W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1083 didemethylchlorpromazine sulfoxide 49.90 707.4 nM 0 redox potentiating 1 0 23.20
2 SGTC_1718 roemerine 11.70 11.9 µM 1.32E-37 redox potentiating 4 4.19E-32 4.29
3 SGTC_576 1073-0113 7.50 22.7 µM 1.57E-16 redox potentiating 10 3.15E-14 0.20
4 SGTC_3 0833-0587 6.87 95.6 µM 3.79E-14 redox potentiating 2 3.30E-12 0.76
5 SGTC_525 k781-2675 5.58 26.7 µM 6.05E-10 redox potentiating 27 1.22E-8 0.02
6 SGTC_4 0960-0234 5.41 25.7 µM 1.80E-9 Golgi 4 3.08E-8 0.32
7 SGTC_1383 3049-0032 5.01 20.7 µM 2.31E-8 60S ribosome export 4 2.69E-7 0.22
8 SGTC_2 0422-0095 5.00 29.0 µM 2.44E-8 redox potentiating 3 2.82E-7 1.25
9 SGTC_2967 9089538 4.70 49.9 µM 1.45E-7 8 1.28E-6 0.03
10 SGTC_1021 4476-0760 4.56 85.3 µM 3.27E-7 2 2.56E-6 1.13
11 SGTC_1725 st036284 4.50 20.6 µM 4.60E-7 4 3.42E-6 0.32
12 SGTC_2693 st077581 4.27 40.7 µM 1.55E-6 4 9.59E-6 0.07
13 SGTC_769 0302-0231 4.11 76.0 µM 3.67E-6 9 2.00E-5 0.05
14 SGTC_3202 9113761 4.07 49.5 µM 4.53E-6 9 2.39E-5 0.03
15 SGTC_1274 0865-0114 4.02 173.0 µM 5.73E-6 8 2.92E-5 0.08
16 SGTC_145 3737-0113 3.77 38.4 µM 1.96E-5 DNA intercalators 55 8.32E-5 0.01
17 SGTC_1611 st001856 3.48 99.4 µM 7.30E-5 14 2.55E-4 0.01
18 SGTC_2919 7978188 3.43 46.4 µM 8.79E-5 6 2.99E-4 0.08
19 SGTC_450 aminopyrene 3.36 156.0 nM 1.19E-4 10 3.86E-4 0.21
20 SGTC_1322 1348-1070 3.33 12.0 µM 1.39E-4 6 4.41E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.741 0 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.561 8.29E-277 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.502 5.94E-214 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.319 1.97E-80 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.317 2.70E-79 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.302 1.01E-71 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.296 5.95E-69 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.289 1.05E-65 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.288 5.11E-65 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.279 4.50E-61 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.271 1.15E-57 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.262 9.75E-54 YCL017C NFS1 het Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
0.260 6.84E-53 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.258 3.87E-52 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.257 1.28E-51 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene