YPL252C / YAH1

Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL252C / YAH1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-3.77|P-value:3.45E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.91|P-value:5.04E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.69|P-value:4.43E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-4.79|P-value:8.29E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:5.56|P-value:2.80E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:4.21|P-value:7.46E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:4.03|P-value:1.43E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.23|P-value:7.02E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:14.60|P-value:1.65E-39 ID:SGTC_628|Compound:1636-0253|FD-Score:3.48|P-value:8.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.40|P-value:3.78E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.47|P-value:9.13E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.54|P-value:7.32E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.46|P-value:9.45E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.44|P-value:9.82E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.89|P-value:5.45E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.47|P-value:2.91E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.85|P-value:2.69E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.41|P-value:5.50E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.49|P-value:8.27E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:45.30|P-value:0 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.71|P-value:4.19E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.54|P-value:7.14E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.14|P-value:9.72E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.18|P-value:8.38E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.96|P-value:4.00E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.89|P-value:2.34E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.36|P-value:4.34E-5 ID:SGTC_1617|Compound:st002906|FD-Score:7.40|P-value:1.35E-11 ID:SGTC_1622|Compound:st003707|FD-Score:-3.71|P-value:4.31E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.67|P-value:1.35E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.93|P-value:2.04E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:20.50|P-value:3.21E-76 ID:SGTC_1763|Compound:st044482|FD-Score:3.45|P-value:9.62E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.01|P-value:3.11E-8 ID:SGTC_1941|Compound:st076221|FD-Score:4.59|P-value:1.82E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.49|P-value:2.70E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.82|P-value:7.25E-6 ID:SGTC_2305|Compound:7443522|FD-Score:3.84|P-value:2.72E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.40|P-value:5.74E-7 ID:SGTC_2624|Compound:nerol|FD-Score:3.77|P-value:3.49E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-4.08|P-value:1.22E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-4.61|P-value:1.70E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.47|P-value:9.04E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.53|P-value:2.24E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.10|P-value:1.12E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.57|P-value:6.54E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.53|P-value:7.56E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.90|P-value:2.24E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.77|P-value:3.45E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.91|P-value:5.04E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.69|P-value:4.43E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-4.79|P-value:8.29E-6 ID:SGTC_525|Compound:k781-2675|FD-Score:5.56|P-value:2.80E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:4.21|P-value:7.46E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:4.03|P-value:1.43E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.23|P-value:7.02E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:14.60|P-value:1.65E-39 ID:SGTC_628|Compound:1636-0253|FD-Score:3.48|P-value:8.76E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.40|P-value:3.78E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.47|P-value:9.13E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.54|P-value:7.32E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.46|P-value:9.45E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.44|P-value:9.82E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.89|P-value:5.45E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:4.47|P-value:2.91E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.85|P-value:2.69E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.41|P-value:5.50E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.49|P-value:8.27E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:45.30|P-value:0 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.71|P-value:4.19E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.54|P-value:7.14E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.14|P-value:9.72E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.18|P-value:8.38E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.96|P-value:4.00E-8 ID:SGTC_1611|Compound:st001856|FD-Score:3.89|P-value:2.34E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.36|P-value:4.34E-5 ID:SGTC_1617|Compound:st002906|FD-Score:7.40|P-value:1.35E-11 ID:SGTC_1622|Compound:st003707|FD-Score:-3.71|P-value:4.31E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.67|P-value:1.35E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.93|P-value:2.04E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:20.50|P-value:3.21E-76 ID:SGTC_1763|Compound:st044482|FD-Score:3.45|P-value:9.62E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.01|P-value:3.11E-8 ID:SGTC_1941|Compound:st076221|FD-Score:4.59|P-value:1.82E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.49|P-value:2.70E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.82|P-value:7.25E-6 ID:SGTC_2305|Compound:7443522|FD-Score:3.84|P-value:2.72E-4 ID:SGTC_2328|Compound:6201408|FD-Score:5.40|P-value:5.74E-7 ID:SGTC_2624|Compound:nerol|FD-Score:3.77|P-value:3.49E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-4.08|P-value:1.22E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-4.61|P-value:1.70E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.47|P-value:9.04E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.53|P-value:2.24E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-4.10|P-value:1.12E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.57|P-value:6.54E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-3.53|P-value:7.56E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.90|P-value:2.24E-4

Top fitness defect scores for YPL252C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1083 didemethylchlorpromazine sulfoxide 45.30 707.4 nM 0 redox potentiating 2 0 23.20
2 SGTC_1718 roemerine 20.50 11.9 µM 3.21E-76 redox potentiating 1 1.29E-93 4.62
3 SGTC_576 1073-0113 14.60 22.7 µM 1.65E-39 redox potentiating 1 2.62E-48 2.46
4 SGTC_1617 st002906 7.40 78.0 µM 1.35E-11 1 6.67E-14 3.53
5 SGTC_1785 bathophenanthroline 6.01 24.0 µM 3.11E-8 heme requiring 8 9.07E-10 0.63
6 SGTC_1248 0469-0687 5.96 58.6 µM 4.00E-8 3 1.24E-9 0.18
7 SGTC_525 k781-2675 5.56 26.7 µM 2.80E-7 redox potentiating 28 1.35E-8 0.09
8 SGTC_905 2-aminofluorene 5.41 215.0 µM 5.50E-7 cell wall signaling 2 3.08E-8 1.11
9 SGTC_2328 6201408 5.40 200.0 µM 5.74E-7 4 3.25E-8 0.09
10 SGTC_407 eburnamonine 4.91 100.0 µM 5.04E-6 2 4.66E-7 0.56
11 SGTC_1959 st077091 4.82 55.8 µM 7.25E-6 RPP1 & pyrimidine depletion 18 7.28E-7 0.37
12 SGTC_1941 st076221 4.59 61.8 µM 1.82E-5 sphingolipid biosynthesis & PDR1 6 2.24E-6 0.13
13 SGTC_2788 5282734 4.53 71.4 µM 2.24E-5 3 2.89E-6 0.32
14 SGTC_1944 st076371 4.49 56.9 µM 2.70E-5 1 3.63E-6 0.49
15 SGTC_764 1951-2361 4.47 146.0 µM 2.91E-5 8 3.98E-6 0.42
16 SGTC_660 4031-1742 4.40 102.0 µM 3.78E-5 redox potentiating 7 5.49E-6 0.25
17 SGTC_1613 st002381 4.36 52.1 µM 4.34E-5 4 6.50E-6 0.01
18 SGTC_573 3702-0553 4.23 84.7 µM 7.02E-5 1 1.17E-5 0.42
19 SGTC_554 4483-2211 4.21 187.0 µM 7.46E-5 1 1.26E-5 0.39
20 SGTC_1231 0242-0792 4.14 125.0 µM 9.72E-5 1 1.74E-5 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.741 0 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.524 6.95E-236 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.484 1.04E-196 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.294 7.67E-68 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.277 3.55E-60 YCL017C NFS1 het Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
0.267 6.28E-56 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.256 3.78E-51 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.253 4.13E-50 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.247 7.08E-48 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.242 9.00E-46 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.240 4.10E-45 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.225 7.30E-40 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.225 9.70E-40 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.223 4.70E-39 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.215 2.56E-36 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor