YPL255W / BBP1

Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL255W / BBP1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.25|P-value:4.08E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.39|P-value:5.67E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.08|P-value:6.99E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.22|P-value:4.83E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.59|P-value:6.98E-7 ID:SGTC_792|Compound:4534-1957|FD-Score:3.86|P-value:2.63E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.17|P-value:4.86E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.01|P-value:3.62E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-5.67|P-value:2.09E-10 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.97|P-value:1.29E-10 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:2.98|P-value:9.89E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.90|P-value:1.20E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.30|P-value:2.99E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.17|P-value:1.89E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.57|P-value:7.51E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.62|P-value:7.69E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.72|P-value:5.15E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.28|P-value:1.23E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.83|P-value:1.00E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.52|P-value:2.68E-9 ID:SGTC_2093|Compound:5331342|FD-Score:-3.40|P-value:7.20E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-3.43|P-value:6.35E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.98|P-value:4.77E-6 ID:SGTC_2137|Compound:5261020|FD-Score:3.03|P-value:8.27E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.06|P-value:2.99E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.11|P-value:2.51E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.91|P-value:2.14E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.15|P-value:2.07E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.05|P-value:3.14E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.91|P-value:5.39E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.35|P-value:8.88E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-2.77|P-value:9.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.49|P-value:1.38E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.77|P-value:4.06E-5 ID:SGTC_2816|Compound:7982706|FD-Score:2.99|P-value:9.77E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.64|P-value:5.18E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-3.03|P-value:3.43E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.52|P-value:4.33E-5 ID:SGTC_2900|Compound:5328528|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.37|P-value:8.31E-5 ID:SGTC_2938|Compound:9059746|FD-Score:2.98|P-value:9.85E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:1.56E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.94|P-value:9.87E-8 ID:SGTC_3016|Compound:9080866|FD-Score:-3.62|P-value:2.73E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.01|P-value:8.91E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.97|P-value:1.64E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.79|P-value:1.22E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.01|P-value:8.92E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.26|P-value:3.44E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.78|P-value:8.86E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.42|P-value:6.61E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.06|P-value:7.45E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.25|P-value:4.08E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:-4.39|P-value:5.67E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.08|P-value:6.99E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.22|P-value:4.83E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:4.59|P-value:6.98E-7 ID:SGTC_792|Compound:4534-1957|FD-Score:3.86|P-value:2.63E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:3.17|P-value:4.86E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.01|P-value:3.62E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-5.67|P-value:2.09E-10 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.97|P-value:1.29E-10 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.23|P-value:3.84E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.35|P-value:2.44E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:2.98|P-value:9.89E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.90|P-value:1.20E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.30|P-value:2.99E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.17|P-value:1.89E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.57|P-value:7.51E-7 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.62|P-value:7.69E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.72|P-value:5.15E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.28|P-value:1.23E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.83|P-value:1.00E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.52|P-value:2.68E-9 ID:SGTC_2093|Compound:5331342|FD-Score:-3.40|P-value:7.20E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-3.43|P-value:6.35E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.98|P-value:4.77E-6 ID:SGTC_2137|Compound:5261020|FD-Score:3.03|P-value:8.27E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.06|P-value:2.99E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.11|P-value:2.51E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.91|P-value:2.14E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.15|P-value:2.07E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.05|P-value:3.14E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.91|P-value:5.39E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.35|P-value:8.88E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-2.77|P-value:9.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.04|P-value:7.98E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.49|P-value:1.38E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.77|P-value:4.06E-5 ID:SGTC_2816|Compound:7982706|FD-Score:2.99|P-value:9.77E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.64|P-value:5.18E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-3.03|P-value:3.43E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.52|P-value:4.33E-5 ID:SGTC_2900|Compound:5328528|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.37|P-value:8.31E-5 ID:SGTC_2938|Compound:9059746|FD-Score:2.98|P-value:9.85E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:1.56E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.94|P-value:9.87E-8 ID:SGTC_3016|Compound:9080866|FD-Score:-3.62|P-value:2.73E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.01|P-value:8.91E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.97|P-value:1.64E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.79|P-value:1.22E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.01|P-value:8.92E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.26|P-value:3.44E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.78|P-value:8.86E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.42|P-value:6.61E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.06|P-value:7.45E-4

Top fitness defect scores for YPL255W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1082 camptothecin 5.97 424.9 nM 1.29E-10 DNA damage response 6 1.16E-9 0.02
2 SGTC_2091 4-phenylthiadiazole 5.52 200.0 µM 2.68E-9 1 1.66E-8 1.84
3 SGTC_2972 9093619 4.94 59.9 µM 9.87E-8 4 3.97E-7 0.77
4 SGTC_1333 1482-0047 4.90 286.0 µM 1.20E-7 2 4.71E-7 0.35
5 SGTC_2818 7996756 4.64 13.0 µM 5.18E-7 3 1.72E-6 0.01
6 SGTC_786 4544-0069 4.59 423.0 µM 6.98E-7 5 2.24E-6 0.13
7 SGTC_1511 0906-3109 4.57 28.5 µM 7.51E-7 excess fatty acid 6 2.38E-6 0.11
8 SGTC_65 0798-0905 4.25 35.0 µM 4.08E-6 calcium & mitochondrial duress 7 1.07E-5 0.43
9 SGTC_776 4476-4378 4.22 112.0 µM 4.83E-6 ERG2 3 1.24E-5 0.07
10 SGTC_3080 9117754 3.97 49.5 µM 1.64E-5 4 3.67E-5 0.15
11 SGTC_2283 7944793 3.91 200.0 µM 2.14E-5 7 4.65E-5 0.18
12 SGTC_792 4534-1957 3.86 155.0 µM 2.63E-5 5 5.57E-5 0.52
13 SGTC_2643 anethole 3.77 100.0 µM 4.06E-5 4 8.22E-5 0.19
14 SGTC_1944 st076371 3.72 56.9 µM 5.15E-5 5 1.02E-4 0.31
15 SGTC_1582 3',3',6'-trihydroxyflavone 3.62 74.0 µM 7.69E-5 6 1.45E-4 0.03
16 SGTC_2560 caryophyllene 3.49 100.0 µM 1.38E-4 11 2.44E-4 0.03
17 SGTC_2966 9084041 3.46 48.0 µM 1.56E-4 7 2.73E-4 0.14
18 SGTC_2433 5607874 3.38 27.8 µM 2.11E-4 7 3.56E-4 0.21
19 SGTC_1321 1326-2144 3.35 215.0 µM 2.44E-4 8 4.07E-4 0.31
20 SGTC_782 0083-0095 3.30 30.5 µM 2.97E-4 4 4.85E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.66E-13 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.101 4.67E-9 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.100 5.60E-9 YNL196C_p SLZ1_p hom Sporulation-specific protein with a leucine zipper motif
0.098 1.52E-8 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.088 3.77E-7 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.087 4.29E-7 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.085 7.34E-7 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.083 1.33E-6 YDR493W MZM1 hom Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog
0.082 2.01E-6 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
0.081 2.69E-6 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.079 4.31E-6 YPL128C TBF1 het Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
0.079 4.67E-6 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 5.65E-6 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.077 8.53E-6 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.075 1.31E-5 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity