YPL256C / CLN2

G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL256C / CLN2

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.09|P-value:6.23E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.23|P-value:3.79E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.07|P-value:6.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.60|P-value:8.59E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.55|P-value:3.58E-9 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.02|P-value:8.25E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.10|P-value:6.19E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:2.99|P-value:9.15E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.98|P-value:9.52E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.06|P-value:9.84E-14 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.76|P-value:3.94E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.81|P-value:3.62E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.19|P-value:4.44E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.02|P-value:8.66E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.35|P-value:2.57E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.61|P-value:8.33E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.60|P-value:8.72E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.79|P-value:3.87E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.86|P-value:2.09E-7 ID:SGTC_2037|Compound:5169046|FD-Score:3.56|P-value:1.03E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.02|P-value:1.40E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.82|P-value:3.32E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.08|P-value:6.44E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.84|P-value:3.39E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.92|P-value:2.38E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.60|P-value:8.18E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.51|P-value:1.26E-6 ID:SGTC_2369|Compound:9071472|FD-Score:3.80|P-value:3.77E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.00|P-value:9.53E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.19|P-value:4.33E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.06|P-value:6.76E-8 ID:SGTC_2795|Compound:7780010|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.04|P-value:7.51E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.23|P-value:5.22E-6 ID:SGTC_2860|Compound:9025725|FD-Score:-4.90|P-value:1.87E-7 ID:SGTC_2862|Compound:9027634|FD-Score:4.21|P-value:5.76E-6 ID:SGTC_2865|Compound:9030313|FD-Score:-5.10|P-value:5.87E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.54|P-value:1.19E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.17|P-value:4.74E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:1.17E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.78|P-value:4.07E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:3.09|P-value:6.23E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.23|P-value:3.79E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.07|P-value:6.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.33|P-value:2.57E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.60|P-value:8.59E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.55|P-value:3.58E-9 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.16|P-value:5.18E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:3.02|P-value:8.25E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.10|P-value:6.19E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.43|P-value:1.88E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:2.99|P-value:9.15E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.98|P-value:9.52E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.06|P-value:9.84E-14 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.76|P-value:3.94E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.81|P-value:3.62E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:2.99|P-value:8.95E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.19|P-value:4.44E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.20|P-value:4.13E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.56|P-value:1.01E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.02|P-value:8.66E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.35|P-value:2.57E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.61|P-value:8.33E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.60|P-value:8.72E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.79|P-value:3.87E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.86|P-value:2.09E-7 ID:SGTC_2037|Compound:5169046|FD-Score:3.56|P-value:1.03E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.02|P-value:1.40E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.82|P-value:3.32E-5 ID:SGTC_2211|Compound:7117706|FD-Score:3.08|P-value:6.44E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.84|P-value:3.39E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.92|P-value:2.38E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.60|P-value:8.18E-7 ID:SGTC_2337|Compound:9009472|FD-Score:4.51|P-value:1.26E-6 ID:SGTC_2369|Compound:9071472|FD-Score:3.80|P-value:3.77E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:3.55|P-value:1.05E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.00|P-value:9.53E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.19|P-value:4.33E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.06|P-value:6.76E-8 ID:SGTC_2795|Compound:7780010|FD-Score:3.23|P-value:3.72E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.04|P-value:7.51E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.23|P-value:5.22E-6 ID:SGTC_2860|Compound:9025725|FD-Score:-4.90|P-value:1.87E-7 ID:SGTC_2862|Compound:9027634|FD-Score:4.21|P-value:5.76E-6 ID:SGTC_2865|Compound:9030313|FD-Score:-5.10|P-value:5.87E-8 ID:SGTC_2868|Compound:9035608|FD-Score:-3.54|P-value:1.19E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.17|P-value:4.74E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:1.17E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.04|P-value:7.63E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.78|P-value:4.07E-5

Top fitness defect scores for YPL256C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1240 0356-0016 7.06 42.1 µM 9.84E-14 mitochondrial response to ROS 5 8.47E-13
2 SGTC_868 0527-0199 5.55 213.0 µM 3.58E-9 fatty acid desaturase (OLE1) 8 1.39E-8
3 SGTC_2755 lomerizine 5.06 42.7 µM 6.76E-8 10 2.11E-7
4 SGTC_2012 4023501 4.86 200.0 µM 2.09E-7 15 6.00E-7
5 SGTC_2331 7980721 4.60 200.0 µM 8.18E-7 13 2.12E-6
6 SGTC_2337 9009472 4.51 200.0 µM 1.26E-6 18 3.17E-6
7 SGTC_2821 7996764 4.23 71.4 µM 5.22E-6 29 1.18E-5
8 SGTC_2862 9027634 4.21 71.4 µM 5.76E-6 ERG2 25 1.29E-5
9 SGTC_2092 5303694 4.02 80.7 µM 1.40E-5 TSC3-RPN4 41 2.93E-5
10 SGTC_2095 5432005 3.82 200.0 µM 3.32E-5 12 6.54E-5
11 SGTC_1244 0416-0015 3.81 52.5 µM 3.62E-5 ERG2 36 7.08E-5
12 SGTC_2369 9071472 3.80 200.0 µM 3.77E-5 19 7.35E-5
13 SGTC_1982 st072467 3.79 71.9 µM 3.87E-5 41 7.54E-5
14 SGTC_3218 9131285 3.78 49.5 µM 4.07E-5 endomembrane recycling 55 7.89E-5
15 SGTC_1886 st057356 3.61 49.9 µM 8.33E-5 60S ribosome export 29 1.53E-4
16 SGTC_644 1498-1197 3.60 63.3 µM 8.59E-5 34 1.58E-4
17 SGTC_1970 st070122 3.60 35.8 µM 8.72E-5 TSC3-RPN4 35 1.60E-4
18 SGTC_706 4262-0057 3.60 46.9 µM 8.81E-5 fatty acid desaturase (OLE1) 49 1.61E-4
19 SGTC_914 3820-6779 3.60 408.0 µM 8.81E-5 34 1.62E-4
20 SGTC_1790 st045711 3.56 43.5 µM 1.01E-4 20 1.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.42E-11 YMR307W GAS1 hom Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
0.107 4.56E-10 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.099 9.28E-9 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.097 2.11E-8 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.092 1.02E-7 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.091 1.41E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.090 1.76E-7 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.090 2.00E-7 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.086 5.39E-7 YIL074C SER33 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication
0.085 7.10E-7 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.085 9.09E-7 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.082 2.13E-6 YOR197W MCA1 hom Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization
0.075 1.22E-5 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.074 1.62E-5 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.072 3.10E-5 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0