YPL257W_p

Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL257W / YPL257W

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:-3.64|P-value:6.68E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.70|P-value:7.64E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:5.18|P-value:8.74E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:-4.34|P-value:6.16E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.09|P-value:1.51E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.77|P-value:5.15E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.05|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.76|P-value:2.39E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.87|P-value:1.65E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.46|P-value:6.37E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.42|P-value:7.13E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.30|P-value:3.35E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.53|P-value:5.09E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:4.01|P-value:9.86E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.37|P-value:2.61E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.51|P-value:5.37E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.57|P-value:4.53E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.26|P-value:3.96E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.52|P-value:9.87E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.74|P-value:5.81E-6 ID:SGTC_1981|Compound:st071826|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.90|P-value:1.49E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.87|P-value:1.63E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.31|P-value:9.99E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.81|P-value:4.40E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.71|P-value:6.69E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.34|P-value:9.19E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.97|P-value:2.28E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.99|P-value:1.08E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.33|P-value:9.64E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-6.29|P-value:1.05E-8 ID:SGTC_2943|Compound:9068529|FD-Score:4.21|P-value:4.85E-5 ID:SGTC_2951|Compound:9072950|FD-Score:4.34|P-value:2.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-4.61|P-value:2.20E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.09|P-value:1.52E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.37|P-value:2.61E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.93|P-value:2.59E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.97|P-value:1.15E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.34|P-value:2.86E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.39|P-value:7.92E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.64|P-value:6.68E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.70|P-value:7.64E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:5.18|P-value:8.74E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:-4.34|P-value:6.16E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-4.09|P-value:1.51E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.77|P-value:5.15E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.05|P-value:1.72E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.76|P-value:2.39E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.87|P-value:1.65E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.46|P-value:6.37E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.42|P-value:7.13E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.30|P-value:3.35E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.53|P-value:5.09E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:4.01|P-value:9.86E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.37|P-value:2.61E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.51|P-value:5.37E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.57|P-value:4.53E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.26|P-value:3.96E-5 ID:SGTC_1791|Compound:st048313|FD-Score:-3.52|P-value:9.87E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.74|P-value:5.81E-6 ID:SGTC_1981|Compound:st071826|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.90|P-value:1.49E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.87|P-value:1.63E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.31|P-value:9.99E-4 ID:SGTC_2148|Compound:5546263|FD-Score:4.81|P-value:4.40E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.71|P-value:6.69E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.34|P-value:9.19E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.97|P-value:2.28E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.99|P-value:1.08E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.33|P-value:9.64E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-6.29|P-value:1.05E-8 ID:SGTC_2943|Compound:9068529|FD-Score:4.21|P-value:4.85E-5 ID:SGTC_2951|Compound:9072950|FD-Score:4.34|P-value:2.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-4.61|P-value:2.20E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-4.09|P-value:1.52E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.37|P-value:2.61E-5 ID:SGTC_3082|Compound:9117008|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.93|P-value:2.59E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.97|P-value:1.15E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.00|P-value:1.02E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.34|P-value:2.86E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.39|P-value:7.92E-4

Top fitness defect scores for YPL257W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_165 k038-0023 5.70 64.4 µM 7.64E-8 ubiquinone biosynthesis & proteasome 28 6.07E-9
2 SGTC_167 3672-0051 5.18 66.2 µM 8.74E-7 19 1.11E-7
3 SGTC_2148 5546263 4.81 113.6 µM 4.40E-6 13 7.57E-7
4 SGTC_668 1682-0499 4.77 62.6 µM 5.15E-6 12 9.11E-7
5 SGTC_1977 st070720 4.74 65.3 µM 5.81E-6 4 1.05E-6
6 SGTC_2150 5556613 4.71 200.0 µM 6.69E-6 8 1.24E-6
7 SGTC_1464 k208-0027 4.37 110.0 µM 2.61E-5 17 6.24E-6
8 SGTC_3001 9076041 4.37 71.4 µM 2.61E-5 9 6.26E-6
9 SGTC_3260 9137109 4.34 49.5 µM 2.86E-5 60S ribosome export 6 6.97E-6
10 SGTC_2951 9072950 4.34 58.1 µM 2.88E-5 ERG2 16 7.03E-6
11 SGTC_1402 3909-7673 4.30 35.9 µM 3.35E-5 16 8.40E-6
12 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.26 90.6 µM 3.96E-5 27 1.02E-5
13 SGTC_2943 9068529 4.21 45.3 µM 4.85E-5 13 1.30E-5
14 SGTC_1435 4092-0789 4.01 56.7 µM 9.86E-5 plasma membrane duress 12 3.01E-5
15 SGTC_3180 9109287 4.00 49.5 µM 1.02E-4 10 3.14E-5
16 SGTC_2327 6189656 3.99 200.0 µM 1.08E-4 23 3.35E-5
17 SGTC_3098 9119039 3.97 49.5 µM 1.15E-4 Golgi 34 3.61E-5
18 SGTC_1982 st072467 3.90 71.9 µM 1.49E-4 38 4.89E-5
19 SGTC_1987 st072290 3.87 61.9 µM 1.63E-4 15 5.45E-5
20 SGTC_1283 0922-0125 3.87 16.4 µM 1.65E-4 23 5.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 5.49E-12 YKR089C TGL4 hom Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p
0.089 2.09E-7 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.076 9.93E-6 YMR295C YMR295C hom Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress
0.074 1.96E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.073 2.23E-5 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.073 2.30E-5 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.066 1.40E-4 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.066 1.44E-4 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.064 2.23E-4 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.063 2.39E-4 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.063 2.45E-4 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.062 3.00E-4 YGR147C NAT2 het Protein with an apparent role in acetylation of N-terminal methionine residues
0.062 3.57E-4 YJL141C YAK1 hom Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
0.060 5.42E-4 YBR240C THI2 hom Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
0.059 5.68E-4 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis