YPL258C / THI21

Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL258C / THI21

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.91|P-value:1.55E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:-4.08|P-value:1.01E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.22|P-value:4.09E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:5.10|P-value:5.23E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:3.11|P-value:6.03E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.13|P-value:8.36E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:2.98|P-value:9.70E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.70|P-value:5.84E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.19|P-value:6.26E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.58|P-value:9.20E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:5.14|P-value:4.34E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.81|P-value:2.42E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:4.17|P-value:7.13E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.67|P-value:6.67E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-2.98|P-value:9.25E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.11|P-value:8.50E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.13|P-value:4.63E-8 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.70|P-value:5.83E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.74|P-value:1.14E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:9.69|P-value:2.67E-24 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.90|P-value:1.50E-7 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.06|P-value:7.28E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.16|P-value:7.36E-6 ID:SGTC_1640|Compound:st009078|FD-Score:-3.72|P-value:4.91E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.05|P-value:7.05E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.46|P-value:1.47E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.28|P-value:4.06E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-2.98|P-value:9.04E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.02|P-value:8.50E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.09|P-value:6.51E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.07|P-value:6.95E-4 ID:SGTC_2299|Compound:7976368|FD-Score:6.05|P-value:1.42E-10 ID:SGTC_2378|Compound:9074213|FD-Score:4.47|P-value:1.60E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.40|P-value:2.04E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.00|P-value:1.46E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.10|P-value:2.86E-26 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.58|P-value:3.11E-9 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.12|P-value:8.74E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.92|P-value:2.21E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.54|P-value:1.05E-4 ID:SGTC_2707|Compound:st078556|FD-Score:5.76|P-value:9.45E-10 ID:SGTC_2740|Compound:felodipine|FD-Score:4.02|P-value:1.43E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:-2.98|P-value:9.11E-4 ID:SGTC_2881|Compound:9058953|FD-Score:6.43|P-value:1.01E-11 ID:SGTC_2893|Compound:9048488|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.32|P-value:2.76E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.14|P-value:8.14E-6 ID:SGTC_3170|Compound:9103054|FD-Score:7.03|P-value:1.15E-13 ID:SGTC_3202|Compound:9113761|FD-Score:3.01|P-value:8.54E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.73|P-value:5.11E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.91|P-value:1.55E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:-4.08|P-value:1.01E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.22|P-value:4.09E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:5.10|P-value:5.23E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:3.11|P-value:6.03E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:4.13|P-value:8.36E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:2.98|P-value:9.70E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.70|P-value:5.84E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.15|P-value:4.88E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:4.19|P-value:6.26E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.58|P-value:9.20E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:5.14|P-value:4.34E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.81|P-value:2.42E-7 ID:SGTC_950|Compound:1165-0508|FD-Score:4.17|P-value:7.13E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.67|P-value:6.67E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.38|P-value:2.21E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-2.98|P-value:9.25E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.11|P-value:8.50E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.13|P-value:4.63E-8 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.70|P-value:5.83E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.74|P-value:1.14E-9 ID:SGTC_1264|Compound:0783-0040|FD-Score:9.69|P-value:2.67E-24 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.90|P-value:1.50E-7 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.06|P-value:7.28E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.16|P-value:7.36E-6 ID:SGTC_1640|Compound:st009078|FD-Score:-3.72|P-value:4.91E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.05|P-value:7.05E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.46|P-value:1.47E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.28|P-value:4.06E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-2.98|P-value:9.04E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.02|P-value:8.50E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.09|P-value:6.51E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.07|P-value:6.95E-4 ID:SGTC_2299|Compound:7976368|FD-Score:6.05|P-value:1.42E-10 ID:SGTC_2378|Compound:9074213|FD-Score:4.47|P-value:1.60E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.40|P-value:2.04E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.00|P-value:1.46E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.09|P-value:6.20E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:10.10|P-value:2.86E-26 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.58|P-value:3.11E-9 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.12|P-value:8.74E-6 ID:SGTC_2678|Compound:equilin|FD-Score:3.92|P-value:2.21E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.54|P-value:1.05E-4 ID:SGTC_2707|Compound:st078556|FD-Score:5.76|P-value:9.45E-10 ID:SGTC_2740|Compound:felodipine|FD-Score:4.02|P-value:1.43E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:-2.98|P-value:9.11E-4 ID:SGTC_2881|Compound:9058953|FD-Score:6.43|P-value:1.01E-11 ID:SGTC_2893|Compound:9048488|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.54|P-value:1.12E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.32|P-value:2.76E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_3151|Compound:9099821|FD-Score:4.14|P-value:8.14E-6 ID:SGTC_3170|Compound:9103054|FD-Score:7.03|P-value:1.15E-13 ID:SGTC_3202|Compound:9113761|FD-Score:3.01|P-value:8.54E-4 ID:SGTC_3224|Compound:9130643|FD-Score:4.45|P-value:1.78E-6 ID:SGTC_3310|Compound:9130229|FD-Score:3.73|P-value:5.11E-5

Top fitness defect scores for YPL258C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 10.10 100.0 µM 2.86E-26 3 2.55E-24
2 SGTC_1264 0783-0040 9.69 158.0 µM 2.67E-24 1 1.66E-22
3 SGTC_3170 9103054 7.03 49.5 µM 1.15E-13 60S ribosome export 1 1.01E-12
4 SGTC_2881 9058953 6.43 52.0 µM 1.01E-11 3 6.26E-11
5 SGTC_2299 7976368 6.05 114.9 µM 1.42E-10 7 7.12E-10
6 SGTC_2707 st078556 5.76 66.6 µM 9.45E-10 2 4.09E-9
7 SGTC_1258 0671-0043 5.74 57.1 µM 1.14E-9 1 4.87E-9
8 SGTC_2639 lactacystin 5.58 53.0 µM 3.11E-9 7 1.22E-8
9 SGTC_829 1635-0120 5.14 117.0 µM 4.34E-8 DNA damage response 17 1.39E-7
10 SGTC_1180 1193-0155 5.13 285.0 µM 4.63E-8 1 1.48E-7
11 SGTC_523 1934-0222 5.10 13.7 µM 5.23E-8 14 1.65E-7
12 SGTC_6 0844-0013 4.91 19.8 µM 1.55E-7 39 4.51E-7
13 SGTC_2378 9074213 4.47 121.4 µM 1.60E-6 RSC complex & mRNA processing 7 3.89E-6
14 SGTC_3224 9130643 4.45 49.5 µM 1.78E-6 RPP1 & pyrimidine depletion 12 4.28E-6
15 SGTC_1869 3',7'-dimethoxyflavone 4.28 40.3 µM 4.06E-6 19 9.17E-6
16 SGTC_822 1487-0950 4.19 154.0 µM 6.26E-6 8 1.37E-5
17 SGTC_950 1165-0508 4.17 94.1 µM 7.13E-6 24 1.54E-5
18 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.16 61.8 µM 7.36E-6 ergosterol biosynthesis 6 1.59E-5
19 SGTC_3151 9099821 4.14 49.5 µM 8.14E-6 13 1.74E-5
20 SGTC_627 1391-0720 4.13 175.0 µM 8.36E-6 11 1.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 5.17E-25 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.118 7.20E-12 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.118 8.01E-12 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.116 1.93E-11 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.115 2.19E-11 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.099 8.14E-9 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.094 4.64E-8 YAL046C AIM1 hom Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
0.090 1.57E-7 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.090 1.69E-7 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.089 2.15E-7 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.087 4.74E-7 YOL091W SPO21 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.086 5.54E-7 YPL263C KEL3 hom Cytoplasmic protein of unknown function
0.083 1.59E-6 YNR075W COS10 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.080 3.15E-6 YPR167C MET16 hom 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.080 3.41E-6 YGR250C YGR250C hom Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress