YPL262W / FUM1

Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL262W / FUM1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:5.69|P-value:1.57E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.35|P-value:5.31E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.30|P-value:8.72E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.89|P-value:7.35E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:4.00|P-value:4.77E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.40|P-value:4.36E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.19|P-value:2.21E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.12|P-value:4.35E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:17.00|P-value:2.81E-61 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:14.50|P-value:4.82E-45 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.01|P-value:8.67E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.51|P-value:4.22E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.74|P-value:1.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.76|P-value:1.73E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.80|P-value:1.53E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.65|P-value:1.80E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.78|P-value:1.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.78|P-value:1.62E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.48|P-value:3.38E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.21|P-value:8.39E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.52|P-value:2.93E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.45|P-value:5.31E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.23|P-value:1.86E-19 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.41|P-value:4.20E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.59|P-value:3.85E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.46|P-value:5.13E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.55|P-value:4.66E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.45|P-value:5.24E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.55|P-value:7.17E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.42|P-value:5.93E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.42|P-value:5.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.64|P-value:2.68E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.44|P-value:3.88E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.36|P-value:5.11E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.55|P-value:3.71E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.78|P-value:1.63E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-6.36|P-value:6.05E-10 ID:SGTC_2279|Compound:7948423|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.17|P-value:9.53E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.23|P-value:7.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.40|P-value:6.35E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.23|P-value:7.76E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.41|P-value:5.96E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.73|P-value:1.35E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.42|P-value:4.10E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.58|P-value:3.40E-4 ID:SGTC_3283|Compound:9109332|FD-Score:5.04|P-value:4.65E-7 ID:SGTC_3297|Compound:9117502|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.65|P-value:1.82E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.69|P-value:1.57E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.35|P-value:5.31E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.30|P-value:8.72E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.89|P-value:7.35E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:4.00|P-value:4.77E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.85|P-value:1.14E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.40|P-value:4.36E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.19|P-value:2.21E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.12|P-value:4.35E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:17.00|P-value:2.81E-61 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:14.50|P-value:4.82E-45 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.01|P-value:8.67E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.51|P-value:4.22E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.74|P-value:1.90E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-3.76|P-value:1.73E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.80|P-value:1.53E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.65|P-value:1.80E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.78|P-value:1.66E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.78|P-value:1.62E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.48|P-value:3.38E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.21|P-value:8.39E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.52|P-value:2.93E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:-3.45|P-value:5.31E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:9.23|P-value:1.86E-19 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.41|P-value:4.20E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.59|P-value:3.85E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:-3.46|P-value:5.13E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.55|P-value:4.66E-6 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.62|P-value:1.98E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.45|P-value:5.24E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.55|P-value:7.17E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-3.42|P-value:5.93E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.42|P-value:5.84E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.64|P-value:2.68E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.44|P-value:3.88E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.36|P-value:5.11E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.55|P-value:3.71E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.78|P-value:1.63E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-6.36|P-value:6.05E-10 ID:SGTC_2279|Compound:7948423|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.17|P-value:9.53E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.23|P-value:7.75E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.40|P-value:6.35E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.23|P-value:7.76E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.41|P-value:5.96E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.73|P-value:1.35E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.42|P-value:4.10E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.58|P-value:3.40E-4 ID:SGTC_3283|Compound:9109332|FD-Score:5.04|P-value:4.65E-7 ID:SGTC_3297|Compound:9117502|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.65|P-value:1.82E-4

Top fitness defect scores for YPL262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_184 1494-0393 17.00 24.7 µM 2.81E-61 1 1.96E-65
2 SGTC_219 mitoxanthrone 14.50 164.4 µM 4.82E-45 DNA intercalators 3 5.14E-48
3 SGTC_996 3970-0799 9.23 1.8 µM 1.86E-19 16 1.35E-20
4 SGTC_36 0335-0881 5.69 14.2 µM 1.57E-8 ubiquinone biosynthesis & proteasome 70 6.33E-9
5 SGTC_3283 9109332 5.04 35.8 µM 4.65E-7 DNA intercalators 4 2.33E-7
6 SGTC_100 0086-0128 4.85 49.6 µM 1.14E-6 copper-dependent oxidative stress 25 6.04E-7
7 SGTC_1269 0831-0796 4.59 3.0 µM 3.85E-6 60S ribosome export 7 2.21E-6
8 SGTC_1557 sumaresinolic acid 4.55 42.3 µM 4.66E-6 8 2.70E-6
9 SGTC_2858 9025781 4.33 9.0 µM 1.23E-5 sphingolipid biosynthesis & PDR1 81 7.57E-6
10 SGTC_2279 7948423 4.33 32.9 µM 1.23E-5 7 7.57E-6
11 SGTC_145 3737-0113 4.19 38.4 µM 2.21E-5 DNA intercalators 68 1.41E-5
12 SGTC_90 0870-0863 4.00 4.6 µM 4.77E-5 45 3.19E-5
13 SGTC_86 0417-1630 3.89 471.9 µM 7.35E-5 ubiquinone biosynthesis & proteasome 156 5.06E-5
14 SGTC_1353 1498-1206 3.79 8.1 µM 1.08E-4 mitochondrial response to ROS 58 7.63E-5
15 SGTC_1926 methyl fluorone black 3.77 53.6 µM 1.16E-4 DNA intercalators 69 8.16E-5
16 SGTC_1551 6-bromo-3'-methylflavone 3.75 63.5 µM 1.23E-4 24 8.72E-5
17 SGTC_892 0929-0076 3.74 29.0 µM 1.29E-4 TRP & mitochondrial translation 50 9.14E-5
18 SGTC_3000 9075062 3.73 71.4 µM 1.35E-4 25 9.66E-5
19 SGTC_628 1636-0253 3.65 16.0 µM 1.80E-4 sphingolipid biosynthesis & PDR1 43 1.30E-4
20 SGTC_3319 9138450 3.65 16.8 µM 1.82E-4 29 1.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 2.21E-45 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.219 1.52E-37 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.219 1.38E-37 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.208 3.67E-34 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.190 1.68E-28 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.184 6.03E-27 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.178 3.14E-25 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.177 6.68E-25 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.166 5.08E-22 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.165 6.64E-22 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.165 6.60E-22 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.165 7.55E-22 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.165 1.04E-21 YBR123C TFC1 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63
0.160 1.72E-20 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.157 7.37E-20 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress