YPL263C / KEL3

Cytoplasmic protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL263C / KEL3

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.50|P-value:4.36E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.14|P-value:2.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.68|P-value:1.81E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.02|P-value:3.76E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:5.58|P-value:2.03E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:4.36|P-value:5.05E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:2.86|P-value:6.49E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.49|P-value:4.42E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.22|P-value:1.48E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.23|P-value:1.56E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.35|P-value:9.76E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.19|P-value:1.90E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.34|P-value:5.50E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:3.30|P-value:1.05E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.94|P-value:4.78E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.09|P-value:2.85E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.88|P-value:6.59E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:-2.83|P-value:7.99E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.83|P-value:8.00E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.16|P-value:2.15E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.14|P-value:2.10E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.61|P-value:2.49E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.79|P-value:8.59E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.85|P-value:6.92E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.57|P-value:3.12E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:2.90|P-value:5.51E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.78|P-value:9.03E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.93|P-value:5.04E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.23|P-value:1.44E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.36|P-value:8.92E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.12|P-value:2.32E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.15|P-value:2.00E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.22|P-value:1.50E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.94|P-value:4.73E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.01|P-value:3.90E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.54|P-value:3.56E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:2.91|P-value:5.34E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.00|P-value:3.77E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.97|P-value:4.22E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:8.33|P-value:4.89E-21 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.83|P-value:7.24E-4 ID:SGTC_2857|Compound:9024691|FD-Score:2.94|P-value:4.79E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.78|P-value:9.82E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.16|P-value:2.17E-4 ID:SGTC_2937|Compound:9044753|FD-Score:2.93|P-value:5.03E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.53|P-value:1.84E-7 ID:SGTC_2985|Compound:9022375|FD-Score:3.54|P-value:3.59E-5 ID:SGTC_3019|Compound:9081971|FD-Score:3.27|P-value:1.19E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-4.52|P-value:2.31E-7 ID:SGTC_3048|Compound:9093155|FD-Score:-3.42|P-value:6.69E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-3.62|P-value:2.74E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.71|P-value:1.73E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.04|P-value:3.49E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.45|P-value:6.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:2.95|P-value:4.55E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.81|P-value:8.06E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.68|P-value:1.85E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.05|P-value:3.07E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.23|P-value:1.61E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.04|P-value:3.17E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.32|P-value:6.32E-7 ID:SGTC_3209|Compound:9113616|FD-Score:5.66|P-value:1.11E-10 ID:SGTC_39|Compound:0986-0283|FD-Score:3.50|P-value:4.36E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.14|P-value:2.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.68|P-value:1.81E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.02|P-value:3.76E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:5.58|P-value:2.03E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:4.36|P-value:5.05E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:2.86|P-value:6.49E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.49|P-value:4.42E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.22|P-value:1.48E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.23|P-value:1.56E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:5.35|P-value:9.76E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.19|P-value:1.90E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.34|P-value:5.50E-7 ID:SGTC_865|Compound:0488-0499|FD-Score:3.30|P-value:1.05E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:2.94|P-value:4.78E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.09|P-value:2.85E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.88|P-value:6.59E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:-2.83|P-value:7.99E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-2.83|P-value:8.00E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.16|P-value:2.15E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.20|P-value:1.61E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.14|P-value:2.10E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.61|P-value:2.49E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.79|P-value:8.59E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.85|P-value:6.92E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.57|P-value:3.12E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:2.90|P-value:5.51E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:2.78|P-value:9.03E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.93|P-value:5.04E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.23|P-value:1.44E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.36|P-value:8.92E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.12|P-value:2.32E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.15|P-value:2.00E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.22|P-value:1.50E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.94|P-value:4.73E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.01|P-value:3.90E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.54|P-value:3.56E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:2.91|P-value:5.34E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.00|P-value:3.77E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.97|P-value:4.22E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:8.33|P-value:4.89E-21 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:2.83|P-value:7.24E-4 ID:SGTC_2857|Compound:9024691|FD-Score:2.94|P-value:4.79E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-2.78|P-value:9.82E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.16|P-value:2.17E-4 ID:SGTC_2937|Compound:9044753|FD-Score:2.93|P-value:5.03E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.53|P-value:1.84E-7 ID:SGTC_2985|Compound:9022375|FD-Score:3.54|P-value:3.59E-5 ID:SGTC_3019|Compound:9081971|FD-Score:3.27|P-value:1.19E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-4.52|P-value:2.31E-7 ID:SGTC_3048|Compound:9093155|FD-Score:-3.42|P-value:6.69E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-3.62|P-value:2.74E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.71|P-value:1.73E-5 ID:SGTC_3054|Compound:9094397|FD-Score:-3.04|P-value:3.49E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.45|P-value:6.03E-5 ID:SGTC_3075|Compound:9116269|FD-Score:2.95|P-value:4.55E-4 ID:SGTC_3078|Compound:9116413|FD-Score:2.81|P-value:8.06E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.68|P-value:1.85E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.05|P-value:3.07E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.23|P-value:1.61E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.04|P-value:3.17E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.32|P-value:6.32E-7 ID:SGTC_3209|Compound:9113616|FD-Score:5.66|P-value:1.11E-10

Top fitness defect scores for YPL263C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 8.33 100.0 µM 4.89E-21 5 3.90E-17
2 SGTC_3209 9113616 5.66 49.5 µM 1.11E-10 2 7.62E-9
3 SGTC_507 nimesulide 5.58 162.0 µM 2.03E-10 8 1.23E-8
4 SGTC_804 1595-0054 5.35 20.9 µM 9.76E-10 sphingolipid biosynthesis & PDR1 16 4.34E-8
5 SGTC_2967 9089538 4.53 49.9 µM 1.84E-7 17 2.91E-6
6 SGTC_534 k292-0788 4.36 63.4 µM 5.05E-7 mitochondrial processes 23 6.55E-6
7 SGTC_809 3998-0021 4.34 90.0 µM 5.50E-7 RNA processing & uracil transport 8 7.01E-6
8 SGTC_3202 9113761 4.32 49.5 µM 6.32E-7 35 7.85E-6
9 SGTC_935 2996-0153 3.88 430.0 µM 6.59E-6 PDR1 21 5.17E-5
10 SGTC_391 gliotoxin 3.68 8.3 µM 1.81E-5 74 1.17E-4
11 SGTC_3081 9117243 3.68 49.5 µM 1.85E-5 fatty acid desaturase (OLE1) 24 1.19E-4
12 SGTC_1216 1165-0504 3.61 9.7 µM 2.49E-5 19 1.51E-4
13 SGTC_1368 1852-0141 3.57 284.0 µM 3.12E-5 ERG2 51 1.81E-4
14 SGTC_2488 5268135 3.54 45.7 µM 3.56E-5 65 2.01E-4
15 SGTC_2985 9022375 3.54 71.4 µM 3.59E-5 RPP1 & pyrimidine depletion 45 2.03E-4
16 SGTC_39 0986-0283 3.50 58.4 µM 4.36E-5 calcium & mitochondrial duress 53 2.37E-4
17 SGTC_650 1328-0195 3.49 38.0 µM 4.42E-5 32 2.39E-4
18 SGTC_865 0488-0499 3.30 301.0 µM 1.05E-4 36 4.80E-4
19 SGTC_3019 9081971 3.27 49.5 µM 1.19E-4 30 5.32E-4
20 SGTC_1721 st082152 3.23 9.3 µM 1.44E-4 60S ribosome export 46 6.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.36E-18 YNL045W LAP2 hom Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.149 3.57E-18 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.123 8.39E-13 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.122 1.13E-12 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.114 3.19E-11 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.112 6.60E-11 YNR003C RPC34 het RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
0.110 1.55E-10 YIL046W-A_p YIL046W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.110 1.58E-10 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
0.107 4.62E-10 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
0.092 1.02E-7 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.089 2.52E-7 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.66E-7 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.088 2.87E-7 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.088 3.16E-7 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.087 4.07E-7 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans