YPL265W / DIP5

Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL265W / DIP5

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:5.06|P-value:4.19E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:3.59|P-value:6.84E-5 ID:SGTC_229|Compound:benomyl|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.44|P-value:1.23E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.67|P-value:3.63E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.62|P-value:5.90E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:2.96|P-value:8.12E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.74|P-value:2.61E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:2.92|P-value:9.25E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-4.01|P-value:1.58E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:5.48|P-value:3.35E-9 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.00|P-value:6.98E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.02|P-value:1.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:2.98|P-value:7.57E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.97|P-value:1.28E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.97|P-value:1.28E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:3.16E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.00|P-value:6.88E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.15|P-value:5.28E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:2.91|P-value:9.57E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.39|P-value:4.11E-19 ID:SGTC_1794|Compound:st048918|FD-Score:-3.06|P-value:7.89E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.54|P-value:8.47E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.17|P-value:3.71E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.89|P-value:1.80E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.34|P-value:2.67E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_2022|Compound:5136654|FD-Score:7.45|P-value:1.78E-15 ID:SGTC_2111|Compound:5486399|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-3.37|P-value:2.41E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:2.97|P-value:7.72E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.83|P-value:2.37E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.22|P-value:1.67E-8 ID:SGTC_2947|Compound:9072639|FD-Score:-3.14|P-value:5.72E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.59|P-value:6.88E-5 ID:SGTC_3139|Compound:9095020|FD-Score:2.96|P-value:8.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.06|P-value:8.22E-6 ID:SGTC_3185|Compound:9108267|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.91|P-value:1.65E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:5.06|P-value:4.19E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:3.59|P-value:6.84E-5 ID:SGTC_229|Compound:benomyl|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.44|P-value:1.23E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.67|P-value:3.63E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.62|P-value:5.90E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:2.96|P-value:8.12E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.74|P-value:2.61E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:2.92|P-value:9.25E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:-4.01|P-value:1.58E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:5.48|P-value:3.35E-9 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.00|P-value:6.98E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:4.02|P-value:1.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:2.98|P-value:7.57E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.97|P-value:1.28E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.33|P-value:2.02E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.97|P-value:1.28E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.30|P-value:3.16E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.00|P-value:6.88E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:2.97|P-value:7.70E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.15|P-value:5.28E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:2.91|P-value:9.57E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.39|P-value:4.11E-19 ID:SGTC_1794|Compound:st048918|FD-Score:-3.06|P-value:7.89E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.54|P-value:8.47E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.18|P-value:3.52E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.17|P-value:3.71E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.89|P-value:1.80E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.34|P-value:2.67E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.22|P-value:3.10E-4 ID:SGTC_2022|Compound:5136654|FD-Score:7.45|P-value:1.78E-15 ID:SGTC_2111|Compound:5486399|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.39|P-value:1.65E-6 ID:SGTC_2165|Compound:5727197|FD-Score:-3.37|P-value:2.41E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:2.97|P-value:7.72E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.83|P-value:2.37E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.22|P-value:1.67E-8 ID:SGTC_2947|Compound:9072639|FD-Score:-3.14|P-value:5.72E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.59|P-value:6.88E-5 ID:SGTC_3139|Compound:9095020|FD-Score:2.96|P-value:8.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.06|P-value:8.22E-6 ID:SGTC_3185|Compound:9108267|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.91|P-value:1.65E-5

Top fitness defect scores for YPL265W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 8.39 55.4 µM 4.11E-19 62 2.35E-17
2 SGTC_2022 5136654 7.45 200.0 µM 1.78E-15 4 4.56E-14
3 SGTC_658 3253-0951 5.48 102.0 µM 3.35E-9 calcium & mitochondrial duress 21 2.13E-8
4 SGTC_2858 9025781 5.22 9.0 µM 1.67E-8 sphingolipid biosynthesis & PDR1 59 9.12E-8
5 SGTC_114 0364-0001 5.06 490.3 µM 4.19E-8 14 2.09E-7
6 SGTC_543 3844-1095 4.74 191.0 µM 2.61E-7 ERG2 34 1.09E-6
7 SGTC_368 fentichlor 4.67 4.6 µM 3.63E-7 15 1.47E-6
8 SGTC_366 0181-0206 4.44 4.3 µM 1.23E-6 Golgi 26 4.41E-6
9 SGTC_2137 5261020 4.39 140.0 µM 1.65E-6 33 5.76E-6
10 SGTC_1527 coumarin 4.15 137.0 µM 5.28E-6 20 1.65E-5
11 SGTC_3174 9107204 4.06 49.5 µM 8.22E-6 ERG2 25 2.46E-5
12 SGTC_718 1130-0073 4.02 349.0 µM 1.01E-5 19 2.95E-5
13 SGTC_919 tnp00227 3.97 403.6 nM 1.28E-5 RNA pol III & RNase P/MRP 35 3.65E-5
14 SGTC_1063 disulfiram 3.97 1.8 µM 1.28E-5 22 3.66E-5
15 SGTC_3305 9127027 3.91 53.8 µM 1.65E-5 17 4.60E-5
16 SGTC_1889 st059080 3.89 5.2 µM 1.80E-5 17 4.99E-5
17 SGTC_1941 st076221 3.88 61.8 µM 1.89E-5 sphingolipid biosynthesis & PDR1 83 5.22E-5
18 SGTC_2752 diclazuril 3.83 33.1 µM 2.37E-5 130 6.38E-5
19 SGTC_951 1171-0579 3.69 82.7 µM 4.41E-5 cell wall 95 1.12E-4
20 SGTC_488 nitrendipine 3.62 139.0 µM 5.90E-5 57 1.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.98E-45 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.223 4.00E-39 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.218 1.76E-37 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.210 8.60E-35 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204 8.55E-33 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.196 2.47E-30 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.196 2.64E-30 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.192 3.06E-29 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184 4.77E-27 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.171 1.98E-23 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.169 6.02E-23 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.166 3.86E-22 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.162 3.94E-21 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.156 1.16E-19 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.153 4.01E-19 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes