YPL266W / DIM1

Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL266W / DIM1

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:2.98|P-value:7.01E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:9.73|P-value:8.37E-26 ID:SGTC_69|Compound:0096-0274|FD-Score:4.00|P-value:8.99E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:9.09|P-value:9.03E-23 ID:SGTC_124|Compound:0136-0217|FD-Score:5.75|P-value:3.54E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:19.40|P-value:8.04E-97 ID:SGTC_274|Compound:sirtinol|FD-Score:4.16|P-value:4.01E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.44|P-value:1.13E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.89|P-value:7.59E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.62|P-value:5.18E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.09|P-value:4.57E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-2.92|P-value:8.49E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:6.89|P-value:7.24E-14 ID:SGTC_674|Compound:0498-0004|FD-Score:3.02|P-value:6.03E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:16.90|P-value:1.06E-73 ID:SGTC_799|Compound:1310-0557|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.93|P-value:8.33E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.17|P-value:3.39E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.39|P-value:1.09E-15 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.41|P-value:1.28E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.16|P-value:3.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.95|P-value:7.80E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.90|P-value:9.26E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.88|P-value:1.47E-10 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.68|P-value:3.89E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.94|P-value:8.21E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.13|P-value:3.92E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.54|P-value:1.37E-9 ID:SGTC_2008|Compound:4012253|FD-Score:4.32|P-value:1.83E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.99|P-value:9.20E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-3.58|P-value:6.01E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.08|P-value:2.55E-8 ID:SGTC_2070|Compound:5230947|FD-Score:3.15|P-value:3.66E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.69|P-value:3.85E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.79|P-value:1.35E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:11.00|P-value:1.22E-32 ID:SGTC_2400|Compound:5203494|FD-Score:5.92|P-value:1.06E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.27|P-value:8.78E-12 ID:SGTC_2449|Compound:5812982|FD-Score:5.89|P-value:1.31E-10 ID:SGTC_2459|Compound:5811157|FD-Score:14.40|P-value:2.03E-54 ID:SGTC_2471|Compound:5466956|FD-Score:15.90|P-value:9.29E-66 ID:SGTC_2475|Compound:5812728|FD-Score:22.60|P-value:2.80E-130 ID:SGTC_2481|Compound:5478948|FD-Score:6.34|P-value:5.21E-12 ID:SGTC_2482|Compound:5981709|FD-Score:7.87|P-value:1.55E-17 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.64|P-value:4.70E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.04|P-value:5.57E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.92|P-value:1.31E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.01|P-value:6.13E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.27|P-value:8.48E-12 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.99|P-value:6.80E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.65|P-value:4.47E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.63|P-value:5.02E-5 ID:SGTC_3009|Compound:9080819|FD-Score:-3.12|P-value:4.05E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.15|P-value:3.63E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.55|P-value:6.98E-5 ID:SGTC_3062|Compound:9077494|FD-Score:4.72|P-value:2.05E-7 ID:SGTC_3130|Compound:9127414|FD-Score:-4.18|P-value:3.64E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-5.37|P-value:4.13E-9 ID:SGTC_3147|Compound:9097027|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.18|P-value:3.22E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.16|P-value:3.55E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.32|P-value:1.86E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:2.98|P-value:7.01E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:9.73|P-value:8.37E-26 ID:SGTC_69|Compound:0096-0274|FD-Score:4.00|P-value:8.99E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:9.09|P-value:9.03E-23 ID:SGTC_124|Compound:0136-0217|FD-Score:5.75|P-value:3.54E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:19.40|P-value:8.04E-97 ID:SGTC_274|Compound:sirtinol|FD-Score:4.16|P-value:4.01E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.44|P-value:1.13E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.89|P-value:7.59E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:3.62|P-value:5.18E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.09|P-value:4.57E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-2.92|P-value:8.49E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:6.89|P-value:7.24E-14 ID:SGTC_674|Compound:0498-0004|FD-Score:3.02|P-value:6.03E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:16.90|P-value:1.06E-73 ID:SGTC_799|Compound:1310-0557|FD-Score:3.03|P-value:5.79E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.93|P-value:8.33E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.17|P-value:3.39E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:7.39|P-value:1.09E-15 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.41|P-value:1.28E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.16|P-value:3.45E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.95|P-value:7.80E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.90|P-value:9.26E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.88|P-value:1.47E-10 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.68|P-value:3.89E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.94|P-value:8.21E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.13|P-value:3.92E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1939|Compound:st074455|FD-Score:5.54|P-value:1.37E-9 ID:SGTC_2008|Compound:4012253|FD-Score:4.32|P-value:1.83E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.99|P-value:9.20E-6 ID:SGTC_2049|Compound:5262831|FD-Score:-3.58|P-value:6.01E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_2068|Compound:5226020|FD-Score:5.08|P-value:2.55E-8 ID:SGTC_2070|Compound:5230947|FD-Score:3.15|P-value:3.66E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.45|P-value:1.09E-4 ID:SGTC_2183|Compound:6420625|FD-Score:3.69|P-value:3.85E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.79|P-value:1.35E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:11.00|P-value:1.22E-32 ID:SGTC_2400|Compound:5203494|FD-Score:5.92|P-value:1.06E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.27|P-value:8.78E-12 ID:SGTC_2449|Compound:5812982|FD-Score:5.89|P-value:1.31E-10 ID:SGTC_2459|Compound:5811157|FD-Score:14.40|P-value:2.03E-54 ID:SGTC_2471|Compound:5466956|FD-Score:15.90|P-value:9.29E-66 ID:SGTC_2475|Compound:5812728|FD-Score:22.60|P-value:2.80E-130 ID:SGTC_2481|Compound:5478948|FD-Score:6.34|P-value:5.21E-12 ID:SGTC_2482|Compound:5981709|FD-Score:7.87|P-value:1.55E-17 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.64|P-value:4.70E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.04|P-value:5.57E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.92|P-value:1.31E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.01|P-value:6.13E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.27|P-value:8.48E-12 ID:SGTC_2763|Compound:lisinopril|FD-Score:2.99|P-value:6.80E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.65|P-value:4.47E-5 ID:SGTC_3001|Compound:9076041|FD-Score:3.63|P-value:5.02E-5 ID:SGTC_3009|Compound:9080819|FD-Score:-3.12|P-value:4.05E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.15|P-value:3.63E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.55|P-value:6.98E-5 ID:SGTC_3062|Compound:9077494|FD-Score:4.72|P-value:2.05E-7 ID:SGTC_3130|Compound:9127414|FD-Score:-4.18|P-value:3.64E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-5.37|P-value:4.13E-9 ID:SGTC_3147|Compound:9097027|FD-Score:-3.42|P-value:1.21E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.18|P-value:3.22E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.16|P-value:3.55E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.32|P-value:1.86E-4

Top fitness defect scores for YPL266W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2475 5812728 22.60 15.0 µM 2.80E-130 mitochondrial processes 1 1.76E-113 6.70
2 SGTC_173 1273-0061 19.40 2.7 µM 8.04E-97 mitochondrial stress 1 2.09E-84 7.16
3 SGTC_730 1436-0052 16.90 41.2 µM 1.06E-73 mitochondrial processes 1 2.60E-64 6.09
4 SGTC_2471 5466956 15.90 24.8 µM 9.29E-66 mitochondrial processes 2 2.07E-57 4.18
5 SGTC_2459 5811157 14.40 9.2 µM 2.03E-54 mitochondrial processes 2 1.49E-47 3.98
6 SGTC_2233 sulbentine 11.00 40.4 µM 1.22E-32 8 1.29E-28 1.02
7 SGTC_63 0099-0242 9.73 26.7 µM 8.37E-26 mitochondrial stress 4 1.13E-22 1.27
8 SGTC_119 0121-0043 9.09 24.8 µM 9.03E-23 mitochondrial stress 2 4.93E-20 1.04
9 SGTC_2482 5981709 7.87 142.7 µM 1.55E-17 PDR1 2 1.77E-15 1.92
10 SGTC_908 3448-7491 7.39 47.7 µM 1.09E-15 mitochondrial stress 2 7.22E-14 1.59
11 SGTC_601 0986-0029 6.89 62.9 µM 7.24E-14 calcium & mitochondrial duress 6 2.78E-12 0.08
12 SGTC_2481 5478948 6.34 45.2 µM 5.21E-12 PDR1 3 1.15E-10 0.51
13 SGTC_2659 sanguinarine 6.27 24.2 µM 8.48E-12 3 1.76E-10 0.33
14 SGTC_2408 sulbentine 6.27 18.4 µM 8.78E-12 17 1.82E-10 0.03
15 SGTC_2400 5203494 5.92 178.7 µM 1.06E-10 RSC complex & mRNA processing 9 1.59E-9 0.40
16 SGTC_2449 5812982 5.89 45.8 µM 1.31E-10 1 1.92E-9 1.04
17 SGTC_1230 0170-0365 5.88 3.8 µM 1.47E-10 endomembrane recycling 13 2.11E-9 0.16
18 SGTC_124 0136-0217 5.75 7.1 µM 3.54E-10 mitochondrial stress 9 4.55E-9 0.01
19 SGTC_1939 st074455 5.54 53.6 µM 1.37E-9 2 1.48E-8 0.72
20 SGTC_2068 5226020 5.08 147.0 µM 2.55E-8 1 1.90E-7 0.46

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.604 0 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.395 1.02E-125 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.198 5.46E-31 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.193 1.39E-29 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.190 1.32E-28 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.190 1.44E-28 YKR085C MRPL20 hom Mitochondrial ribosomal protein of the large subunit
0.169 6.33E-23 YPR133C SPN1 het Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
0.168 9.96E-23 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.168 1.32E-22 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.164 1.06E-21 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.164 1.21E-21 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.163 2.52E-21 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.163 2.71E-21 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.158 2.66E-20 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.158 4.27E-20 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals