YPL267W / ACM1

Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL267W / ACM1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.45|P-value:6.13E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.71|P-value:5.42E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:4.47|P-value:1.46E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.49|P-value:5.40E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.83|P-value:2.08E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.68|P-value:3.45E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.45|P-value:1.58E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.60|P-value:4.53E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.60|P-value:3.80E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.60|P-value:3.69E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.97|P-value:1.74E-6 ID:SGTC_2112|Compound:5488546|FD-Score:4.81|P-value:3.54E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-3.67|P-value:3.57E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.47|P-value:5.70E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.78|P-value:2.45E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.68|P-value:5.80E-8 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.98|P-value:1.20E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-5.29|P-value:5.08E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.40|P-value:8.75E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.63|P-value:4.16E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.93|P-value:1.46E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.62|P-value:3.52E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.78|P-value:2.46E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.13|P-value:5.66E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.04|P-value:9.91E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.24|P-value:5.04E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.45|P-value:6.13E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.71|P-value:5.42E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:4.47|P-value:1.46E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.49|P-value:5.40E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.83|P-value:2.08E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.68|P-value:3.45E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.45|P-value:1.58E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.60|P-value:4.53E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.60|P-value:3.80E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.60|P-value:3.69E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.97|P-value:1.74E-6 ID:SGTC_2112|Compound:5488546|FD-Score:4.81|P-value:3.54E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-3.67|P-value:3.57E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.47|P-value:5.70E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.78|P-value:2.45E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_2456|Compound:5770359|FD-Score:5.68|P-value:5.80E-8 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.98|P-value:1.20E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-5.29|P-value:5.08E-7 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.40|P-value:8.75E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.63|P-value:4.16E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.93|P-value:1.46E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.62|P-value:3.52E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.78|P-value:2.46E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.13|P-value:5.66E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-4.04|P-value:9.91E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.24|P-value:5.04E-7

Top fitness defect scores for YPL267W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2456 5770359 5.68 74.5 µM 5.80E-8 3 6.85E-9
2 SGTC_3148 9097893 5.24 49.5 µM 5.04E-7 20 8.20E-8
3 SGTC_2012 4023501 4.97 200.0 µM 1.74E-6 12 3.39E-7
4 SGTC_2112 5488546 4.81 200.0 µM 3.54E-6 TSC3-RPN4 11 7.68E-7
5 SGTC_128 0906-2981 4.71 13.4 µM 5.42E-6 6 1.25E-6
6 SGTC_130 0136-0219 4.47 337.7 µM 1.46E-5 13 3.88E-6
7 SGTC_1036 k216-0215 4.45 33.5 µM 1.58E-5 mitochondrial response to ROS 37 4.27E-6
8 SGTC_2379 9035213 4.43 200.0 µM 1.76E-5 11 4.82E-6
9 SGTC_2974 9094440 4.13 9.7 µM 5.66E-5 ergosterol biosynthesis 41 1.83E-5
10 SGTC_73 0327-0325 3.92 16.2 µM 1.23E-4 DNA damage response 52 4.44E-5
11 SGTC_1474 0330-0125 3.81 5.3 µM 1.80E-4 34 6.88E-5
12 SGTC_2401 5128683 3.79 200.0 µM 1.95E-4 47 7.56E-5
13 SGTC_2907 7721985 3.62 69.9 µM 3.52E-4 34 1.48E-4
14 SGTC_1791 st048313 3.60 56.1 µM 3.69E-4 22 1.56E-4
15 SGTC_1374 2889-5571 3.60 141.0 µM 3.80E-4 RSC complex & mRNA processing 55 1.61E-4
16 SGTC_669 0108-0021 3.55 26.2 µM 4.50E-4 fatty acid desaturase (OLE1) 110 1.96E-4
17 SGTC_371 0195-0006 3.49 7.4 µM 5.40E-4 32 2.41E-4
18 SGTC_2138 5575593 3.47 77.7 µM 5.70E-4 20 2.57E-4
19 SGTC_125 0133-0007 3.45 11.8 µM 6.13E-4 DNA intercalators 21 2.79E-4
20 SGTC_3037 9091026 3.27 49.5 µM 0.00110 NEO1-PIK1 177 5.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.09E-13 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.102 3.78E-9 YOR263C_d YOR263C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
0.101 4.71E-9 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.084 1.09E-6 YHR093W_d AHT1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
0.082 2.07E-6 YGR210C_p YGR210C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.079 4.32E-6 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.076 9.31E-6 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.076 9.51E-6 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.072 2.70E-5 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.072 2.73E-5 YJL112W MDV1 hom Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
0.072 2.96E-5 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.072 3.23E-5 YOL108C INO4 hom Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.069 6.19E-5 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.067 9.63E-5 YNR050C LYS9 hom Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
0.067 1.04E-4 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif