YPL272C_p

Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL272C / YPL272C

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.58|P-value:4.77E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.73|P-value:2.90E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.69|P-value:3.31E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.39|P-value:6.52E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.81|P-value:1.54E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.21|P-value:6.91E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:3.44|P-value:7.60E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.68|P-value:3.47E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.19|P-value:5.38E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.96|P-value:1.28E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.33|P-value:7.96E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.51|P-value:6.10E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.50|P-value:6.22E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.44|P-value:7.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.59|P-value:4.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.53|P-value:5.68E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.10|P-value:7.53E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.50|P-value:6.35E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.83|P-value:1.46E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.74|P-value:2.75E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.37|P-value:7.05E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.13|P-value:6.73E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.15|P-value:4.34E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.35|P-value:2.94E-5 ID:SGTC_2464|Compound:5717415|FD-Score:5.26|P-value:5.45E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.19|P-value:5.45E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.99|P-value:1.15E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.36|P-value:9.86E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.49|P-value:6.48E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.75|P-value:5.55E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.38|P-value:9.29E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.69|P-value:3.26E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.74|P-value:3.74E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.78|P-value:4.94E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-4.65|P-value:5.58E-6 ID:SGTC_47|Compound:0149-0135|FD-Score:3.58|P-value:4.77E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.73|P-value:2.90E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.69|P-value:3.31E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.02|P-value:1.03E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.39|P-value:6.52E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.81|P-value:1.54E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:5.21|P-value:6.91E-7 ID:SGTC_638|Compound:3970-0837|FD-Score:3.44|P-value:7.60E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.68|P-value:3.47E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.19|P-value:5.38E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.96|P-value:1.28E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.33|P-value:7.96E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.49|P-value:6.49E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.51|P-value:6.10E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.50|P-value:6.22E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.44|P-value:7.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.59|P-value:4.61E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.53|P-value:5.68E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.10|P-value:7.53E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.50|P-value:6.35E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.83|P-value:1.46E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.74|P-value:2.75E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.37|P-value:7.05E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.13|P-value:6.73E-5 ID:SGTC_2299|Compound:7976368|FD-Score:-4.15|P-value:4.34E-5 ID:SGTC_2308|Compound:7584454|FD-Score:4.35|P-value:2.94E-5 ID:SGTC_2464|Compound:5717415|FD-Score:5.26|P-value:5.45E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.19|P-value:5.45E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.99|P-value:1.15E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.36|P-value:9.86E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.49|P-value:6.48E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.75|P-value:5.55E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.38|P-value:9.29E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.69|P-value:3.26E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-4.74|P-value:3.74E-6 ID:SGTC_3216|Compound:9129716|FD-Score:4.78|P-value:4.94E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-4.65|P-value:5.58E-6

Top fitness defect scores for YPL272C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2464 5717415 5.26 7.7 µM 5.45E-7 3 7.12E-8
2 SGTC_581 0958-0271 5.21 211.0 µM 6.91E-7 23 9.35E-8
3 SGTC_3216 9129716 4.78 49.5 µM 4.94E-6 RPP1 & pyrimidine depletion 13 8.97E-7
4 SGTC_2939 9044578 4.75 71.4 µM 5.55E-6 25 1.02E-6
5 SGTC_2308 7584454 4.35 197.6 µM 2.94E-5 15 6.94E-6
6 SGTC_836 0330-0104 4.19 1.4 µM 5.38E-5 10 1.39E-5
7 SGTC_2592 piperlongumine 4.19 83.3 µM 5.45E-5 TSC3-RPN4 31 1.41E-5
8 SGTC_2236 dapsone 4.13 200.0 µM 6.73E-5 6 1.80E-5
9 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.10 14.9 µM 7.53E-5 9 2.04E-5
10 SGTC_320 4092-0846 4.02 5.3 µM 1.03E-4 ergosterol depletion effects on membrane 46 2.95E-5
11 SGTC_2655 perillic acid 3.99 100.0 µM 1.15E-4 3 3.33E-5
12 SGTC_874 0599-0792 3.96 117.0 µM 1.28E-4 28 3.75E-5
13 SGTC_2088 5278280 3.74 127.4 µM 2.75E-4 30 9.06E-5
14 SGTC_125 0133-0007 3.73 11.8 µM 2.90E-4 DNA intercalators 13 9.64E-5
15 SGTC_3025 9087895 3.69 49.5 µM 3.26E-4 PDR1 47 1.10E-4
16 SGTC_272 doxorubicin 3.69 8.1 µM 3.31E-4 anthracycline transcription coupled DNA repair 28 1.12E-4
17 SGTC_792 4534-1957 3.68 155.0 µM 3.47E-4 46 1.18E-4
18 SGTC_1564 D-Arginine 3.59 115.0 µM 4.61E-4 40 1.64E-4
19 SGTC_47 0149-0135 3.58 24.2 µM 4.77E-4 TSC3-RPN4 28 1.70E-4
20 SGTC_2975 9084847 3.55 53.7 µM 5.29E-4 35 1.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.80E-10 YMR053C STB2 hom Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
0.085 8.68E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.082 2.32E-6 YPL008W CHL1 hom Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome
0.079 4.86E-6 YHR191C CTF8 hom Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
0.077 7.47E-6 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.076 1.20E-5 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.076 1.21E-5 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.074 1.92E-5 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.073 2.44E-5 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene
0.073 2.63E-5 YPL179W PPQ1 hom Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
0.070 4.54E-5 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose
0.070 5.16E-5 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.069 6.42E-5 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.068 9.14E-5 YBR074W_p YBR074W_p hom Putative metalloprotease
0.067 1.05E-4 YLR116W MSL5 het Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA