YPL273W / SAM4

S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL273W / SAM4

Click on Significant Values for Screen Details ID:SGTC_142|Compound:0335-0849|FD-Score:3.07|P-value:5.81E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.62|P-value:5.16E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:3.17|P-value:3.92E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.36|P-value:1.86E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.25|P-value:2.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.96|P-value:7.48E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.95|P-value:9.22E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.94|P-value:9.44E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.07|P-value:5.81E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.94|P-value:9.44E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.67|P-value:5.23E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.00|P-value:7.54E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.14|P-value:4.50E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.76|P-value:3.50E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.61|P-value:6.62E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.51|P-value:1.02E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.98|P-value:8.10E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.96|P-value:8.51E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:1.75E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.36|P-value:7.13E-9 ID:SGTC_1521|Compound:st012942|FD-Score:3.11|P-value:5.02E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.30|P-value:2.39E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.09|P-value:5.49E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_2045|Compound:5106652|FD-Score:5.43|P-value:4.72E-9 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:1.06E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.11|P-value:5.06E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.01|P-value:7.10E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.57|P-value:8.06E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.49|P-value:1.13E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.36|P-value:1.93E-4 ID:SGTC_2505|Compound:galangin|FD-Score:2.94|P-value:9.18E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.24|P-value:3.12E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:9.94E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.10|P-value:5.30E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.67|P-value:3.90E-7 ID:SGTC_3075|Compound:9116269|FD-Score:5.17|P-value:2.30E-8 ID:SGTC_3103|Compound:9120822|FD-Score:3.24|P-value:2.99E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.84|P-value:2.42E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.86|P-value:2.18E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.81|P-value:2.72E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.07|P-value:5.81E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.62|P-value:5.16E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:3.17|P-value:3.92E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.36|P-value:1.86E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.25|P-value:2.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.96|P-value:7.48E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.95|P-value:9.22E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:2.94|P-value:9.44E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.07|P-value:5.81E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.94|P-value:9.44E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.67|P-value:5.23E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.00|P-value:7.54E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.14|P-value:4.50E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-3.76|P-value:3.50E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.61|P-value:6.62E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.51|P-value:1.02E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:2.98|P-value:8.10E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:2.96|P-value:8.51E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.91|P-value:1.75E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.36|P-value:7.13E-9 ID:SGTC_1521|Compound:st012942|FD-Score:3.11|P-value:5.02E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.30|P-value:2.39E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.09|P-value:5.49E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_2045|Compound:5106652|FD-Score:5.43|P-value:4.72E-9 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:1.06E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.11|P-value:5.06E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.01|P-value:7.10E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.57|P-value:8.06E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.49|P-value:1.13E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.36|P-value:1.93E-4 ID:SGTC_2505|Compound:galangin|FD-Score:2.94|P-value:9.18E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.24|P-value:3.12E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:9.94E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.10|P-value:5.30E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.67|P-value:3.90E-7 ID:SGTC_3075|Compound:9116269|FD-Score:5.17|P-value:2.30E-8 ID:SGTC_3103|Compound:9120822|FD-Score:3.24|P-value:2.99E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.84|P-value:2.42E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.86|P-value:2.18E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.81|P-value:2.72E-5

Top fitness defect scores for YPL273W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2045 5106652 5.43 78.0 µM 4.72E-9 2 2.88E-8
2 SGTC_1291 0993-0025 5.36 5.8 µM 7.13E-9 2 4.17E-8
3 SGTC_3075 9116269 5.17 49.5 µM 2.30E-8 6 1.19E-7
4 SGTC_360 0957-0399 4.96 1.0 µM 7.48E-8 cell wall 24 3.44E-7
5 SGTC_3013 9080133 4.67 71.4 µM 3.90E-7 7 1.51E-6
6 SGTC_2814 7977482 4.03 43.0 µM 9.94E-6 49 2.77E-5
7 SGTC_2059 5238311 4.02 157.0 µM 1.06E-5 24 2.95E-5
8 SGTC_1247 0448-0043 3.91 5.8 µM 1.75E-5 ERG2 44 4.60E-5
9 SGTC_3222 9128301 3.86 49.5 µM 2.18E-5 60S ribosome export 27 5.62E-5
10 SGTC_3180 9109287 3.84 49.5 µM 2.42E-5 15 6.17E-5
11 SGTC_3329 9141233 3.81 27.6 µM 2.72E-5 17 6.84E-5
12 SGTC_777 1315-0167 3.67 517.0 µM 5.23E-5 Golgi 35 1.23E-4
13 SGTC_1055 3448-0672 3.61 86.0 µM 6.62E-5 41 1.52E-4
14 SGTC_2318 6029776 3.57 164.0 µM 8.06E-5 43 1.82E-4
15 SGTC_1143 3454-2408 3.51 5.1 µM 1.02E-4 60S ribosome export 5 2.24E-4
16 SGTC_268 camptothecin 3.36 39.6 µM 1.86E-4 DNA damage response 110 3.86E-4
17 SGTC_1836 st055642 3.30 81.0 µM 2.36E-4 45 4.78E-4
18 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.30 90.6 µM 2.39E-4 57 4.84E-4
19 SGTC_270 tamoxifen 3.25 5.5 µM 2.95E-4 NEO1 66 5.84E-4
20 SGTC_3103 9120822 3.24 49.5 µM 2.99E-4 38 5.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.46E-22 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.120 2.98E-12 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.111 1.29E-10 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.100 5.85E-9 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.098 1.24E-8 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.094 4.29E-8 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.093 6.15E-8 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.091 1.14E-7 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.089 2.56E-7 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.088 3.06E-7 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.77E-7 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.081 2.37E-6 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.081 2.69E-6 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.081 2.69E-6 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.081 2.86E-6 YJR150C DAN1 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth