YPR002W / PDH1

Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR002W / PDH1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.90|P-value:1.54E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.16|P-value:5.87E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.21|P-value:4.91E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.97|P-value:1.18E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.51|P-value:7.44E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.02|P-value:1.01E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.03|P-value:9.56E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.12|P-value:9.40E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:8.03|P-value:7.08E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.22|P-value:4.69E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.55|P-value:5.07E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.74|P-value:8.40E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:-5.04|P-value:2.36E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.68|P-value:3.28E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.40|P-value:2.35E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.36|P-value:3.83E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.89|P-value:1.58E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-4.15|P-value:8.45E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.34|P-value:9.75E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.34|P-value:9.60E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.67|P-value:8.00E-6 ID:SGTC_1678|Compound:st019265|FD-Score:-4.67|P-value:1.16E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.03|P-value:9.43E-5 ID:SGTC_1891|Compound:st059073|FD-Score:5.27|P-value:5.79E-7 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.55|P-value:6.62E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.60|P-value:1.18E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.34|P-value:9.66E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.22|P-value:4.64E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.70|P-value:3.09E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.97|P-value:2.17E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.40|P-value:8.11E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.49|P-value:6.00E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.96|P-value:1.24E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.90|P-value:1.54E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.53|P-value:2.01E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:5.01|P-value:1.84E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.65|P-value:4.86E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.88|P-value:1.63E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.58|P-value:1.64E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.45|P-value:6.94E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.57|P-value:4.61E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.38|P-value:8.67E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.36|P-value:9.05E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.75|P-value:3.49E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.68|P-value:4.30E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.90|P-value:1.54E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.16|P-value:5.87E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.21|P-value:4.91E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.97|P-value:1.18E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.51|P-value:7.44E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.02|P-value:1.01E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.03|P-value:9.56E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.36|P-value:9.15E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.12|P-value:9.40E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:8.03|P-value:7.08E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.22|P-value:4.69E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.55|P-value:5.07E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.74|P-value:8.40E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:-5.04|P-value:2.36E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.68|P-value:3.28E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.40|P-value:2.35E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:-4.36|P-value:3.83E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.89|P-value:1.58E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-4.15|P-value:8.45E-5 ID:SGTC_1660|Compound:st012960|FD-Score:3.34|P-value:9.75E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.34|P-value:9.60E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.67|P-value:8.00E-6 ID:SGTC_1678|Compound:st019265|FD-Score:-4.67|P-value:1.16E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.03|P-value:9.43E-5 ID:SGTC_1891|Compound:st059073|FD-Score:5.27|P-value:5.79E-7 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.55|P-value:6.62E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.60|P-value:1.18E-7 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.34|P-value:9.66E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.22|P-value:4.64E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.70|P-value:3.09E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.97|P-value:2.17E-6 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.40|P-value:8.11E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.49|P-value:6.00E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.96|P-value:1.24E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.90|P-value:1.54E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.53|P-value:2.01E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:5.01|P-value:1.84E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.65|P-value:4.86E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.88|P-value:1.63E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.58|P-value:1.64E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.45|P-value:6.94E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.57|P-value:4.61E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.38|P-value:8.67E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.51|P-value:5.67E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.36|P-value:9.05E-4 ID:SGTC_3250|Compound:9135583|FD-Score:-3.75|P-value:3.49E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.68|P-value:4.30E-4

Top fitness defect scores for YPR002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_958 1222-0007 8.03 33.0 µM 7.08E-14 3 4.81E-16
2 SGTC_2112 5488546 5.60 200.0 µM 1.18E-7 TSC3-RPN4 4 1.07E-8
3 SGTC_1891 st059073 5.27 26.2 µM 5.79E-7 TSC3-RPN4 8 6.96E-8
4 SGTC_2761 levamisole 5.01 97.9 µM 1.84E-6 5 2.71E-7
5 SGTC_2536 dehydroabietamide 4.97 32.0 µM 2.17E-6 8 3.29E-7
6 SGTC_1675 st018485 4.67 24.5 µM 8.00E-6 60S ribosome export 13 1.52E-6
7 SGTC_1526 st051518 4.40 75.0 µM 2.35E-5 15 5.39E-6
8 SGTC_2436 5633522 4.22 8.1 µM 4.64E-5 11 1.20E-5
9 SGTC_1026 k007-1105 4.22 30.6 µM 4.69E-5 ERAD & cell cycle 87 1.21E-5
10 SGTC_76 0433-0009 4.21 400.3 µM 4.91E-5 10 1.28E-5
11 SGTC_73 0327-0325 4.16 16.2 µM 5.87E-5 DNA damage response 41 1.58E-5
12 SGTC_1683 st010134 4.03 710.0 nM 9.43E-5 24 2.75E-5
13 SGTC_388 3',4'-dichloroisocoumarin 4.03 16.7 µM 9.56E-5 13 2.79E-5
14 SGTC_278 4092-0821 4.02 23.9 µM 1.01E-4 plasma membrane duress 39 2.97E-5
15 SGTC_106 0092-0003 3.97 11.6 µM 1.18E-4 copper-dependent oxidative stress 17 3.58E-5
16 SGTC_2573 2',4'-dihydroxychalcone 3.96 15.0 µM 1.24E-4 48 3.79E-5
17 SGTC_65 0798-0905 3.90 35.0 µM 1.54E-4 calcium & mitochondrial duress 87 4.87E-5
18 SGTC_2588 indole-3-carbinol 3.90 100.0 µM 1.54E-4 46 4.89E-5
19 SGTC_1575 cyproterone acetate 3.89 48.0 µM 1.58E-4 21 5.01E-5
20 SGTC_2834 9001755 3.88 58.4 µM 1.63E-4 38 5.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.71E-9 YPL267W ACM1 hom Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein
0.097 1.75E-8 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.094 4.99E-8 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.084 1.10E-6 YLR042C_p YLR042C_p hom Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
0.083 1.32E-6 YEL014C_d YEL014C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.32E-6 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.082 2.20E-6 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.079 4.72E-6 YOL041C NOP12 hom Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
0.076 1.07E-5 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.074 1.61E-5 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.070 4.55E-5 YDL135C RDI1 hom Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
0.069 6.51E-5 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.068 8.14E-5 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.068 9.02E-5 YLR056W ERG3 hom C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase
0.067 9.67E-5 YBR225W_p YBR225W_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components