YPR005C / HAL1

Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR005C / HAL1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.78|P-value:3.66E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.22|P-value:7.79E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.63|P-value:6.05E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.59|P-value:4.28E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.99|P-value:1.80E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.88|P-value:1.61E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.24|P-value:4.33E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.18|P-value:5.43E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.58|P-value:6.89E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-4.02|P-value:1.63E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-4.33|P-value:5.30E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.23|P-value:7.58E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.73|P-value:2.72E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.80|P-value:4.61E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.57|P-value:7.10E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.87|P-value:1.66E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.83|P-value:1.91E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.90|P-value:1.53E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.77|P-value:2.38E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.66|P-value:3.42E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.81|P-value:2.08E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.62|P-value:3.86E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.31|P-value:3.14E-9 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.87|P-value:1.68E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.44|P-value:6.96E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.68|P-value:3.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.55|P-value:7.73E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.43|P-value:7.22E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.67|P-value:5.32E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.43|P-value:7.23E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.73|P-value:2.72E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.71|P-value:4.65E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.60|P-value:4.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.77|P-value:5.35E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-5.23|P-value:1.33E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-5.02|P-value:3.27E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.58|P-value:6.96E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.41|P-value:7.62E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.80|P-value:2.16E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.88|P-value:1.62E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.71|P-value:4.64E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.63|P-value:3.75E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.78|P-value:3.66E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.22|P-value:7.79E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.63|P-value:6.05E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.59|P-value:4.28E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.99|P-value:1.80E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.73|P-value:2.69E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.88|P-value:1.61E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.24|P-value:4.33E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.18|P-value:5.43E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.58|P-value:6.89E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-4.02|P-value:1.63E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-4.33|P-value:5.30E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.23|P-value:7.58E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.73|P-value:2.72E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.80|P-value:4.61E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.57|P-value:7.10E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.87|P-value:1.66E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.83|P-value:1.91E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.90|P-value:1.53E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.77|P-value:2.38E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.66|P-value:3.42E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.81|P-value:2.08E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.62|P-value:3.86E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:6.31|P-value:3.14E-9 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.87|P-value:1.68E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.44|P-value:6.96E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.68|P-value:3.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.55|P-value:7.73E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.43|P-value:7.22E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.67|P-value:5.32E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.43|P-value:7.23E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.73|P-value:2.72E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.71|P-value:4.65E-4 ID:SGTC_1813|Compound:st051246|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.92|P-value:1.42E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.60|P-value:4.12E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.77|P-value:5.35E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-5.23|P-value:1.33E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-5.02|P-value:3.27E-6 ID:SGTC_2287|Compound:7945887|FD-Score:-3.58|P-value:6.96E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.41|P-value:7.62E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.80|P-value:2.16E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.71|P-value:2.91E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.88|P-value:1.62E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.71|P-value:4.64E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.63|P-value:3.75E-4

Top fitness defect scores for YPR005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1335 1486-0900 6.31 202.0 µM 3.14E-9 9 1.39E-10
2 SGTC_801 0866-0028 4.80 10.1 µM 4.61E-6 12 7.91E-7
3 SGTC_1935 st074532 4.77 41.6 µM 5.35E-6 15 9.42E-7
4 SGTC_1813 st051246 4.60 8.6 µM 1.06E-5 TSC3-RPN4 6 2.12E-6
5 SGTC_269 exalamide 4.24 29.0 µM 4.33E-5 ergosterol biosynthesis 16 1.11E-5
6 SGTC_272 doxorubicin 4.18 8.1 µM 5.43E-5 anthracycline transcription coupled DNA repair 17 1.45E-5
7 SGTC_2556 citropten 3.95 84.6 µM 1.27E-4 25 3.96E-5
8 SGTC_1823 3-hydroxy-2-naphthoic acid 3.92 106.0 µM 1.42E-4 15 4.48E-5
9 SGTC_518 1021-0119 3.92 62.6 µM 1.42E-4 ERG2 36 4.49E-5
10 SGTC_1196 1588-0294 3.90 184.0 µM 1.53E-4 14 4.91E-5
11 SGTC_256 clotrimazole 3.88 625.0 nM 1.61E-4 ergosterol depletion effects on membrane 28 5.20E-5
12 SGTC_3010 9080089 3.88 71.4 µM 1.62E-4 14 5.25E-5
13 SGTC_955 1216-0110 3.87 33.0 µM 1.66E-4 sphingolipid biosynthesis & PDR1 69 5.40E-5
14 SGTC_1337 1486-1011 3.87 40.3 µM 1.68E-4 17 5.47E-5
15 SGTC_958 1222-0007 3.83 33.0 µM 1.91E-4 29 6.38E-5
16 SGTC_1298 1079-1278 3.81 263.0 µM 2.08E-4 DNA damage response 20 7.05E-5
17 SGTC_2754 granisetron 3.80 64.0 µM 2.16E-4 36 7.37E-5
18 SGTC_1640 st009078 3.77 66.4 µM 2.33E-4 12 8.05E-5
19 SGTC_1217 1183-1422 3.77 255.0 µM 2.38E-4 16 8.25E-5
20 SGTC_166 k072-0058 3.73 166.4 µM 2.69E-4 DNA intercalators 46 9.54E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 5.23E-7 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.081 2.98E-6 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.079 4.68E-6 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.076 1.08E-5 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.074 1.65E-5 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.074 1.77E-5 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.072 3.13E-5 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.069 6.60E-5 YHR081W LRP1 hom Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
0.068 9.09E-5 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.067 1.14E-4 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.066 1.18E-4 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.066 1.29E-4 YCL010C SGF29 hom Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation
0.064 2.14E-4 YAL025C MAK16 het Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
0.064 2.26E-4 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.063 2.34E-4 YJL089W SIP4 hom C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus