YPR010C / RPA135

RNA polymerase I second largest subunit A135

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR010C / RPA135

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-3.02|P-value:5.53E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.95|P-value:9.60E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.91|P-value:8.36E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.48|P-value:8.07E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.24|P-value:2.34E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.20|P-value:2.76E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.08|P-value:4.33E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.98|P-value:6.37E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.65|P-value:3.94E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.60|P-value:3.36E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:3.56|P-value:5.70E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.96|P-value:6.62E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.91|P-value:8.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.01|P-value:5.67E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.38|P-value:1.07E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.95|P-value:9.94E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-2.98|P-value:6.43E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.65|P-value:4.04E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.87|P-value:9.65E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.97|P-value:6.56E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.03|P-value:5.25E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.95|P-value:7.01E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.88|P-value:8.92E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.00|P-value:5.84E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.74|P-value:1.41E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:2.89|P-value:8.83E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.67|P-value:3.54E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.08|P-value:4.32E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.00|P-value:5.78E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.02|P-value:5.53E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.95|P-value:9.60E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.91|P-value:8.36E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.48|P-value:8.07E-5 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-3.24|P-value:2.34E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.20|P-value:2.76E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.08|P-value:4.33E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-2.98|P-value:6.37E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.65|P-value:3.94E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.60|P-value:3.36E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:3.56|P-value:5.70E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.96|P-value:6.62E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.91|P-value:8.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.01|P-value:5.67E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.38|P-value:1.07E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.95|P-value:9.94E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-2.98|P-value:6.43E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.65|P-value:4.04E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.87|P-value:9.65E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.97|P-value:6.56E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.03|P-value:5.25E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.95|P-value:7.01E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.88|P-value:8.92E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.00|P-value:5.84E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.74|P-value:1.41E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:2.89|P-value:8.83E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.67|P-value:3.54E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.08|P-value:4.32E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.00|P-value:5.78E-4

Top fitness defect scores for YPR010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2130 NSC 7 4.74 2.5 µM 1.41E-7 copper-dependent oxidative stress 3 1.05E-6 0.37
2 SGTC_1059 3448-6867 4.38 171.0 µM 1.07E-6 2 6.00E-6 0.38
3 SGTC_156 3474-0145 3.95 5.6 µM 9.60E-6 endomembrane recycling 5 3.94E-5 0.03
4 SGTC_2616 abietic acid 3.67 100.0 µM 3.54E-5 5 1.21E-4 0.00
5 SGTC_629 3448-6466 3.65 76.7 µM 3.94E-5 4 1.33E-4 0.07
6 SGTC_751 0833-0568 3.56 350.0 µM 5.70E-5 3 1.83E-4 0.16
7 SGTC_404 fumagillin 3.48 50.0 µM 8.07E-5 9 2.47E-4 0.08
8 SGTC_967 1306-0166 3.43 352.0 µM 1.02E-4 1 3.01E-4 0.14
9 SGTC_2103 5378138 3.21 10.0 µM 2.58E-4 6 6.71E-4 0.01
10 SGTC_2620 irigenin 3.08 100.0 µM 4.32E-4 28 0.00105 0.03
11 SGTC_3042 9091578 3.00 49.5 µM 5.78E-4 ERG2 5 0.00135 0.20
12 SGTC_2125 5246583 3.00 200.0 µM 5.84E-4 tubulin folding & SWR complex 16 0.00136 0.05
13 SGTC_1370 2001-0092 2.97 44.6 µM 6.56E-4 13 0.00150 0.05
14 SGTC_987 1497-1013 2.96 404.0 µM 6.62E-4 12 0.00151 0.05
15 SGTC_1691 st019933 2.95 84.6 µM 7.01E-4 8 0.00159 0.07
16 SGTC_1000 4048-0884 2.91 8.7 µM 8.17E-4 copper-dependent oxidative stress 24 0.00182 0.01
17 SGTC_2605 digitonin 2.89 300.0 nM 8.83E-4 14 0.00194 0.01
18 SGTC_2121 5257820 2.88 149.6 µM 8.92E-4 12 0.00196 0.07
19 SGTC_1379 2144-0755 2.84 36.5 µM 0.00105 16 0.00226 0.04
20 SGTC_1262 0737-0114 2.82 49.6 µM 0.00113 15 0.00240 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 8.27E-47 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.224 3.04E-39 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.223 3.20E-39 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.222 9.37E-39 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.222 9.45E-39 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.221 2.39E-38 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.221 2.58E-38 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.216 9.16E-37 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.216 1.07E-36 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.213 6.53E-36 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.213 9.16E-36 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.211 4.79E-35 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.202 3.38E-32 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.201 5.40E-32 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.200 1.72E-31 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants