YPR011C_p

Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR011C / YPR011C

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-2.74|P-value:9.35E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.86|P-value:5.81E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.93|P-value:3.98E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.24|P-value:1.21E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-2.81|P-value:7.15E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.90|P-value:4.87E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.14|P-value:1.83E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.26|P-value:9.76E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.80|P-value:8.01E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:-6.23|P-value:6.96E-13 ID:SGTC_656|Compound:4090-1979|FD-Score:5.38|P-value:4.02E-10 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.24|P-value:1.17E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.66|P-value:1.66E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.79|P-value:7.15E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.76|P-value:8.71E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:2.71|P-value:9.73E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.88|P-value:4.84E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.28|P-value:8.85E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.75|P-value:9.08E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.42|P-value:4.69E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.97|P-value:3.78E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.85|P-value:5.41E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.07|P-value:2.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.03|P-value:2.39E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:5.90|P-value:7.99E-12 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.79|P-value:7.35E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.93|P-value:4.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.88|P-value:5.37E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.75|P-value:9.25E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.72|P-value:1.23E-5 ID:SGTC_1703|Compound:st026983|FD-Score:2.73|P-value:8.93E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.06|P-value:1.97E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.05|P-value:2.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.85|P-value:6.10E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.99|P-value:3.14E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.01|P-value:3.18E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.85|P-value:6.05E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.33|P-value:7.84E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.41|P-value:5.51E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.86|P-value:1.38E-11 ID:SGTC_2245|Compound:6637752|FD-Score:2.97|P-value:3.35E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:1.39E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.01|P-value:2.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-2.73|P-value:9.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.76|P-value:8.89E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.33|P-value:7.77E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-3.43|P-value:4.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.89|P-value:4.75E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-2.90|P-value:5.01E-4 ID:SGTC_3337|Compound:9144342|FD-Score:2.77|P-value:7.54E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.74|P-value:9.35E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.86|P-value:5.81E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.93|P-value:3.98E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.24|P-value:1.21E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-2.81|P-value:7.15E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.90|P-value:4.87E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.14|P-value:1.83E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.26|P-value:9.76E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.80|P-value:8.01E-6 ID:SGTC_655|Compound:k060-0012|FD-Score:-6.23|P-value:6.96E-13 ID:SGTC_656|Compound:4090-1979|FD-Score:5.38|P-value:4.02E-10 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.24|P-value:1.17E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.66|P-value:1.66E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.79|P-value:7.15E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.76|P-value:8.71E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:2.71|P-value:9.73E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.88|P-value:4.84E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.28|P-value:8.85E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.75|P-value:9.08E-6 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.42|P-value:4.69E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.21|P-value:1.21E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.97|P-value:3.78E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.85|P-value:5.41E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.07|P-value:2.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.03|P-value:2.39E-6 ID:SGTC_1312|Compound:1218-2183|FD-Score:5.90|P-value:7.99E-12 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.79|P-value:7.35E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.93|P-value:4.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.88|P-value:5.37E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.75|P-value:9.25E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.72|P-value:1.23E-5 ID:SGTC_1703|Compound:st026983|FD-Score:2.73|P-value:8.93E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.06|P-value:1.97E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.05|P-value:2.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.85|P-value:6.10E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.99|P-value:3.14E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.01|P-value:3.18E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-2.85|P-value:6.05E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.33|P-value:7.84E-5 ID:SGTC_2238|Compound:6671620|FD-Score:-3.41|P-value:5.51E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.86|P-value:1.38E-11 ID:SGTC_2245|Compound:6637752|FD-Score:2.97|P-value:3.35E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.67|P-value:1.39E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.01|P-value:2.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-2.73|P-value:9.75E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.76|P-value:8.89E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.33|P-value:7.77E-5 ID:SGTC_2908|Compound:7930301|FD-Score:-3.43|P-value:4.95E-5 ID:SGTC_2989|Compound:9073649|FD-Score:2.89|P-value:4.75E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-2.90|P-value:5.01E-4 ID:SGTC_3337|Compound:9144342|FD-Score:2.77|P-value:7.54E-4

Top fitness defect scores for YPR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1312 1218-2183 5.90 165.0 µM 7.99E-12 2 1.79E-9
2 SGTC_656 4090-1979 5.38 187.0 µM 4.02E-10 3 3.71E-8
3 SGTC_1295 1013-0063 3.85 9.8 µM 5.41E-6 15 5.92E-5
4 SGTC_1318 1280-3875 3.79 124.0 µM 7.35E-6 29 7.51E-5
5 SGTC_667 1498-1044 3.76 59.0 µM 8.71E-6 RPP1 & pyrimidine depletion 22 8.58E-5
6 SGTC_996 3970-0799 3.75 1.8 µM 9.08E-6 92 8.86E-5
7 SGTC_2316 5844804 3.67 197.4 µM 1.39E-5 43 1.24E-4
8 SGTC_1000 4048-0884 3.42 8.7 µM 4.69E-5 copper-dependent oxidative stress 50 3.18E-4
9 SGTC_942 3253-1115 3.28 227.0 µM 8.85E-5 56 5.22E-4
10 SGTC_606 k015-0008 3.26 38.6 µM 9.76E-5 39 5.63E-4
11 SGTC_1125 tnp00248 3.21 1.3 µM 1.21E-4 78 6.67E-4
12 SGTC_1301 naphtanilide LB 3.07 4.8 µM 2.23E-4 heme requiring 36 0.00107
13 SGTC_2344 7990960 3.01 77.0 µM 2.92E-4 65 0.00133
14 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.99 70.1 µM 3.14E-4 89 0.00140
15 SGTC_2245 6637752 2.97 200.0 µM 3.35E-4 38 0.00148
16 SGTC_248 streptozotocin 2.93 5.2 mM 3.98E-4 DNA damage response 57 0.00169
17 SGTC_1432 4049-0298 2.93 68.4 µM 4.08E-4 37 0.00172
18 SGTC_2989 9073649 2.89 71.4 µM 4.75E-4 105 0.00194
19 SGTC_686 1319-0111 2.88 510.0 µM 4.84E-4 60S ribosome export 75 0.00197
20 SGTC_663 1486-0733 2.79 13.9 µM 7.15E-4 cell wall signaling 122 0.00267

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.48E-41 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.209 2.16E-34 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.188 4.10E-28 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.184 7.41E-27 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.174 3.69E-24 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.170 4.17E-23 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.162 3.72E-21 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.161 8.68E-21 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.158 3.44E-20 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.155 1.92E-19 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.147 8.99E-18 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.141 2.15E-16 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.136 2.87E-15 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.135 4.53E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.130 4.32E-14 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member