YPR012W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR012W / YPR012W

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-4.00|P-value:1.57E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.04|P-value:1.29E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.86|P-value:2.41E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:4.47E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:4.87|P-value:2.34E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.16|P-value:4.96E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:7.17|P-value:5.29E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:6.73|P-value:1.57E-12 ID:SGTC_789|Compound:1309-1135|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.41|P-value:1.94E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.78|P-value:4.63E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.11|P-value:6.44E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.60|P-value:9.88E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:2.82E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.72|P-value:5.29E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.13|P-value:5.97E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.46|P-value:1.73E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.78|P-value:4.68E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.21|P-value:6.59E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.10|P-value:6.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:9.22E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.55|P-value:1.18E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.06|P-value:1.31E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.25|P-value:3.63E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.69|P-value:6.67E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_1989|Compound:st071868|FD-Score:5.57|P-value:3.96E-9 ID:SGTC_2053|Compound:5265679|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.09|P-value:6.59E-8 ID:SGTC_2317|Compound:5986382|FD-Score:3.09|P-value:7.01E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.91|P-value:2.65E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.14|P-value:9.33E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.36|P-value:2.88E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.34|P-value:3.55E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.90|P-value:5.04E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.45|P-value:2.07E-6 ID:SGTC_2818|Compound:7996756|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.23|P-value:2.96E-8 ID:SGTC_2869|Compound:9037858|FD-Score:3.23|P-value:4.21E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.10|P-value:6.71E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.60|P-value:9.65E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.32|P-value:2.94E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.05|P-value:8.03E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.21|P-value:4.53E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.04|P-value:7.66E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.63|P-value:7.82E-5 ID:SGTC_3175|Compound:9106517|FD-Score:5.26|P-value:2.60E-8 ID:SGTC_3218|Compound:9131285|FD-Score:-3.09|P-value:6.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.84|P-value:3.27E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-4.00|P-value:1.57E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.04|P-value:1.29E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.86|P-value:2.41E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.27|P-value:4.47E-6 ID:SGTC_169|Compound:k015-0017|FD-Score:4.87|P-value:2.34E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.16|P-value:4.96E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.38|P-value:2.35E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:7.17|P-value:5.29E-14 ID:SGTC_518|Compound:1021-0119|FD-Score:6.73|P-value:1.57E-12 ID:SGTC_789|Compound:1309-1135|FD-Score:3.38|P-value:2.40E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.41|P-value:1.94E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.24|P-value:4.07E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.78|P-value:4.63E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.11|P-value:6.44E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.60|P-value:9.88E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.89|P-value:2.82E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.72|P-value:5.29E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.13|P-value:5.97E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.10|P-value:6.64E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.46|P-value:1.73E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.78|P-value:4.68E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.21|P-value:6.59E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.10|P-value:6.75E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:9.22E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.55|P-value:1.18E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.06|P-value:1.31E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.25|P-value:3.63E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.69|P-value:6.67E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.42|P-value:2.04E-4 ID:SGTC_1989|Compound:st071868|FD-Score:5.57|P-value:3.96E-9 ID:SGTC_2053|Compound:5265679|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_2112|Compound:5488546|FD-Score:5.09|P-value:6.59E-8 ID:SGTC_2317|Compound:5986382|FD-Score:3.09|P-value:7.01E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.91|P-value:2.65E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.14|P-value:9.33E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.36|P-value:2.88E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.34|P-value:3.55E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.90|P-value:5.04E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.45|P-value:2.07E-6 ID:SGTC_2818|Compound:7996756|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.23|P-value:2.96E-8 ID:SGTC_2869|Compound:9037858|FD-Score:3.23|P-value:4.21E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.10|P-value:6.71E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.60|P-value:9.65E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.32|P-value:2.94E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.05|P-value:8.03E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.21|P-value:4.53E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.04|P-value:7.66E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.63|P-value:7.82E-5 ID:SGTC_3175|Compound:9106517|FD-Score:5.26|P-value:2.60E-8 ID:SGTC_3218|Compound:9131285|FD-Score:-3.09|P-value:6.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.57|P-value:1.10E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.84|P-value:3.27E-5

Top fitness defect scores for YPR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_513 4245-1575 7.17 41.7 µM 5.29E-14 unfolded protein response 31 3.67E-13
2 SGTC_518 1021-0119 6.73 62.6 µM 1.57E-12 ERG2 8 8.59E-12
3 SGTC_2596 sinensetin 5.90 100.0 µM 5.04E-10 4 1.86E-9
4 SGTC_1989 st071868 5.57 50.2 µM 3.96E-9 2 1.27E-8
5 SGTC_3175 9106517 5.26 49.5 µM 2.60E-8 iron homeostasis 7 7.33E-8
6 SGTC_2824 7998404 5.23 52.0 µM 2.96E-8 12 8.28E-8
7 SGTC_2112 5488546 5.09 200.0 µM 6.59E-8 TSC3-RPN4 7 1.74E-7
8 SGTC_169 k015-0017 4.87 16.0 µM 2.34E-7 10 5.69E-7
9 SGTC_135 0933-0004 4.86 26.4 µM 2.41E-7 60S ribosome export 9 5.85E-7
10 SGTC_2775 cyproheptadine 4.45 69.6 µM 2.07E-6 8 4.36E-6
11 SGTC_2573 2',4'-dihydroxychalcone 4.34 15.0 µM 3.55E-6 36 7.20E-6
12 SGTC_1424 4048-1941 4.21 275.0 µM 6.59E-6 20 1.28E-5
13 SGTC_2406 ethylparaben 4.14 405.7 µM 9.33E-6 27 1.77E-5
14 SGTC_1681 tripelennamine 4.06 100.0 µM 1.31E-5 18 2.44E-5
15 SGTC_2397 5161689 3.91 200.0 µM 2.65E-5 40 4.69E-5
16 SGTC_1183 1254-0324 3.89 198.0 µM 2.82E-5 21 4.99E-5
17 SGTC_1122 capsaicin 3.78 818.6 nM 4.63E-5 35 7.91E-5
18 SGTC_1400 3771-8998 3.78 51.5 µM 4.68E-5 12 7.99E-5
19 SGTC_1953 st076800 3.69 12.1 µM 6.67E-5 55 1.11E-4
20 SGTC_2992 9074591 3.60 71.4 µM 9.65E-5 21 1.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.93E-13 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.120 2.51E-12 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.118 7.61E-12 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.112 7.80E-11 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.108 3.64E-10 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.108 4.11E-10 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.100 7.07E-9 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.098 1.25E-8 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.095 3.21E-8 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.093 6.19E-8 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.089 2.80E-7 YMR090W_p YMR090W_p hom Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
0.085 8.19E-7 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.084 1.01E-6 YHR176W FMO1 hom Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
0.084 1.08E-6 YER106W MAM1 hom Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
0.084 1.10E-6 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1