YPR014C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR014C / YPR014C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.42|P-value:4.59E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:7.54E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:6.45|P-value:3.23E-10 ID:SGTC_165|Compound:k038-0023|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.58|P-value:5.18E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.89|P-value:8.41E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.83|P-value:2.07E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.90|P-value:8.26E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:4.23|P-value:2.24E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:-6.03|P-value:1.01E-8 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.01|P-value:5.29E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.59|P-value:4.84E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.34|P-value:5.87E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.66|P-value:1.95E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.87|P-value:1.76E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.56|P-value:2.77E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.63|P-value:4.09E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:5.35|P-value:1.37E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:5.17|P-value:3.36E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:3.23|P-value:8.65E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:6.06|P-value:3.09E-9 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.89|P-value:1.26E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.04|P-value:9.61E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.70|P-value:1.70E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.40|P-value:4.88E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.95|P-value:9.76E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.37|P-value:5.35E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.36|P-value:5.56E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.66|P-value:3.72E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.54|P-value:2.97E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.19|P-value:2.63E-5 ID:SGTC_1755|Compound:st041960|FD-Score:5.45|P-value:8.09E-8 ID:SGTC_1761|Compound:st044296|FD-Score:-3.45|P-value:7.53E-4 ID:SGTC_1860|Compound:st056228|FD-Score:8.48|P-value:2.75E-16 ID:SGTC_1864|Compound:st057645|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.39|P-value:9.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.96|P-value:6.49E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.62|P-value:2.30E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.46|P-value:7.36E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.14|P-value:3.27E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.19|P-value:9.75E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.21|P-value:8.96E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.34|P-value:5.96E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.73|P-value:2.91E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.01|P-value:1.07E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.66|P-value:3.74E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.52|P-value:6.07E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.53|P-value:3.15E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.02|P-value:1.02E-4 ID:SGTC_2971|Compound:9092186|FD-Score:5.72|P-value:2.05E-8 ID:SGTC_3181|Compound:9108277|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.42|P-value:4.59E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:7.54E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:6.45|P-value:3.23E-10 ID:SGTC_165|Compound:k038-0023|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:4.58|P-value:5.18E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.89|P-value:8.41E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.83|P-value:2.07E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.90|P-value:8.26E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:4.23|P-value:2.24E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:-6.03|P-value:1.01E-8 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.01|P-value:5.29E-5 ID:SGTC_480|Compound:am 92016|FD-Score:4.59|P-value:4.84E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.34|P-value:5.87E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.66|P-value:1.95E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.33|P-value:6.23E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.87|P-value:1.76E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.56|P-value:2.77E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.63|P-value:4.09E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:5.35|P-value:1.37E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:5.17|P-value:3.36E-7 ID:SGTC_988|Compound:1497-1057|FD-Score:3.23|P-value:8.65E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:6.06|P-value:3.09E-9 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.89|P-value:1.26E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.38|P-value:9.61E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.04|P-value:9.61E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.70|P-value:1.70E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.40|P-value:4.88E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.95|P-value:9.76E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.37|P-value:5.35E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.36|P-value:5.56E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-3.66|P-value:3.72E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.54|P-value:2.97E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.19|P-value:2.63E-5 ID:SGTC_1755|Compound:st041960|FD-Score:5.45|P-value:8.09E-8 ID:SGTC_1761|Compound:st044296|FD-Score:-3.45|P-value:7.53E-4 ID:SGTC_1860|Compound:st056228|FD-Score:8.48|P-value:2.75E-16 ID:SGTC_1864|Compound:st057645|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.39|P-value:9.31E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.96|P-value:6.49E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.62|P-value:2.30E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.54|P-value:2.98E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.46|P-value:7.36E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.14|P-value:3.27E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.19|P-value:9.75E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.21|P-value:8.96E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.34|P-value:5.96E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.73|P-value:2.91E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-4.01|P-value:1.07E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.66|P-value:3.74E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.52|P-value:6.07E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.53|P-value:3.15E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.02|P-value:1.02E-4 ID:SGTC_2971|Compound:9092186|FD-Score:5.72|P-value:2.05E-8 ID:SGTC_3181|Compound:9108277|FD-Score:3.70|P-value:1.72E-4

Top fitness defect scores for YPR014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1860 st056228 8.48 74.6 µM 2.75E-16 1 1.10E-17
2 SGTC_74 000s-0487 6.45 160.3 µM 3.23E-10 4 5.61E-11
3 SGTC_1008 4106-0037 6.06 6.0 µM 3.09E-9 PDR1 5 6.76E-10
4 SGTC_2971 9092186 5.72 9.9 µM 2.05E-8 ergosterol biosynthesis 9 5.45E-9
5 SGTC_1755 st041960 5.45 45.2 µM 8.09E-8 8 2.46E-8
6 SGTC_937 3122-0005 5.35 46.7 µM 1.37E-7 10 4.40E-8
7 SGTC_966 1300-0360 5.17 30.2 µM 3.36E-7 heme requiring 6 1.18E-7
8 SGTC_1177 0983-0204 4.95 23.6 µM 9.76E-7 3 3.79E-7
9 SGTC_1073 triclabendazole 4.89 3.1 µM 1.26E-6 14 5.00E-7
10 SGTC_911 3456-4043 4.63 236.0 µM 4.09E-6 mitochondrial processes 17 1.83E-6
11 SGTC_480 am 92016 4.59 50.0 µM 4.84E-6 4 2.19E-6
12 SGTC_193 1273-0060 4.58 1.6 µM 5.18E-6 ergosterol biosynthesis 4 2.36E-6
13 SGTC_325 2810-4341 4.23 181.0 µM 2.24E-5 amide catabolism 9 1.17E-5
14 SGTC_1617 st002906 4.19 78.0 µM 2.63E-5 23 1.40E-5
15 SGTC_2639 lactacystin 4.14 53.0 µM 3.27E-5 18 1.77E-5
16 SGTC_464 bw-b 70c 4.01 158.0 µM 5.29E-5 23 3.00E-5
17 SGTC_2162 5663267 3.96 200.0 µM 6.49E-5 12 3.75E-5
18 SGTC_270 tamoxifen 3.90 5.5 µM 8.26E-5 NEO1 31 4.88E-5
19 SGTC_219 mitoxanthrone 3.89 164.4 µM 8.41E-5 DNA intercalators 53 4.98E-5
20 SGTC_1152 3909-8331 3.70 15.9 µM 1.70E-4 13 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 4.45E-8 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.090 1.88E-7 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.086 5.32E-7 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.081 2.54E-6 YFR021W ATG18 hom Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
0.079 4.09E-6 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.079 5.24E-6 YLR017W MEU1 hom Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
0.078 5.45E-6 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.077 7.30E-6 YMR224C MRE11 hom Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
0.076 1.08E-5 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.075 1.43E-5 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.075 1.54E-5 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.073 2.25E-5 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.073 2.31E-5 YJR002W MPP10 het Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
0.072 2.63E-5 YHR023W MYO1 het Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
0.072 2.79E-5 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies