YPR015C_p

Putative protein of unknown function; overexpression causes a cell cycle delay or arrest

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR015C / YPR015C

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:3.35|P-value:6.41E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.05|P-value:5.37E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.18|P-value:3.37E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:5.65|P-value:2.94E-8 ID:SGTC_667|Compound:1498-1044|FD-Score:3.34|P-value:6.80E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.59|P-value:5.20E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.72|P-value:2.95E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.93|P-value:8.23E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.89|P-value:9.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.31|P-value:1.77E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.80|P-value:2.03E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.64|P-value:2.48E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.51|P-value:3.78E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.54|P-value:3.48E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:5.39|P-value:1.19E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.31|P-value:7.77E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.39|P-value:1.28E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.03|P-value:5.40E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.43|P-value:4.90E-4 ID:SGTC_1819|Compound:st053448|FD-Score:4.09|P-value:4.35E-5 ID:SGTC_1826|Compound:st055655|FD-Score:4.58|P-value:5.54E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.15|P-value:3.48E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.22|P-value:9.83E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.74|P-value:1.67E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:4.70E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.49|P-value:4.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.32|P-value:7.08E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.72|P-value:1.89E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.87|P-value:1.47E-6 ID:SGTC_3145|Compound:9085516|FD-Score:5.74|P-value:1.82E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:3.35|P-value:6.41E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-4.05|P-value:5.37E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.18|P-value:3.37E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:5.65|P-value:2.94E-8 ID:SGTC_667|Compound:1498-1044|FD-Score:3.34|P-value:6.80E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.59|P-value:5.20E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.72|P-value:2.95E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.93|P-value:8.23E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.89|P-value:9.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.31|P-value:1.77E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.80|P-value:2.03E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.64|P-value:2.48E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.51|P-value:3.78E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.54|P-value:3.48E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:5.39|P-value:1.19E-7 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.31|P-value:7.77E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.39|P-value:1.28E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:4.03|P-value:5.40E-5 ID:SGTC_1608|Compound:st001473|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.43|P-value:4.90E-4 ID:SGTC_1819|Compound:st053448|FD-Score:4.09|P-value:4.35E-5 ID:SGTC_1826|Compound:st055655|FD-Score:4.58|P-value:5.54E-6 ID:SGTC_1910|Compound:st062352|FD-Score:4.15|P-value:3.48E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.22|P-value:9.83E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.44|P-value:4.91E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.74|P-value:1.67E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:4.70E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.49|P-value:4.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.32|P-value:7.08E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.72|P-value:1.89E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.87|P-value:1.47E-6 ID:SGTC_3145|Compound:9085516|FD-Score:5.74|P-value:1.82E-8

Top fitness defect scores for YPR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3145 9085516 5.74 49.5 µM 1.82E-8 fatty acid desaturase (OLE1) 7 4.69E-9
2 SGTC_630 4356-0227 5.65 183.0 µM 2.94E-8 2 7.90E-9
3 SGTC_1476 4112-3294 5.39 3.3 µM 1.19E-7 60S ribosome export 2 3.60E-8
4 SGTC_586 0957-0265 5.18 8.2 µM 3.37E-7 cell wall 25 1.11E-7
5 SGTC_3143 9086658 4.87 49.5 µM 1.47E-6 20 5.49E-7
6 SGTC_1363 1636-0063 4.80 10.4 µM 2.03E-6 Golgi 13 7.82E-7
7 SGTC_1080 nisoldipine 4.72 24.4 µM 2.95E-6 TSC3-RPN4 12 1.17E-6
8 SGTC_706 4262-0057 4.59 46.9 µM 5.20E-6 fatty acid desaturase (OLE1) 15 2.17E-6
9 SGTC_1826 st055655 4.58 41.6 µM 5.54E-6 ERG2 29 2.32E-6
10 SGTC_1484 3473-2379 4.39 286.0 µM 1.28E-5 8 5.74E-6
11 SGTC_1264 0783-0040 4.31 158.0 µM 1.77E-5 16 8.15E-6
12 SGTC_1910 st062352 4.15 60.4 µM 3.48E-5 28 1.70E-5
13 SGTC_1819 st053448 4.09 58.6 µM 4.35E-5 amide catabolism 17 2.16E-5
14 SGTC_1588 farnesol 4.03 29.9 µM 5.40E-5 7 2.74E-5
15 SGTC_1121 fusaric acid 3.93 630.5 nM 8.23E-5 35 4.32E-5
16 SGTC_1126 isoteolin 3.89 1.0 µM 9.34E-5 28 4.95E-5
17 SGTC_1608 st001473 3.86 40.5 µM 1.08E-4 38 5.77E-5
18 SGTC_2618 avocadyne 3.74 43.4 µM 1.67E-4 35 9.30E-5
19 SGTC_1439 4092-1168 3.51 46.0 µM 3.78E-4 21 2.25E-4
20 SGTC_2842 9000675 3.49 19.5 µM 4.11E-4 38 2.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.48E-11 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.102 2.99E-9 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.101 3.96E-9 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
0.097 1.88E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.088 3.34E-7 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.085 7.69E-7 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.083 1.44E-6 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.70E-6 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.082 2.19E-6 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.081 2.92E-6 YOL062C APM4 hom Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
0.080 3.45E-6 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.080 3.69E-6 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.080 3.98E-6 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.079 4.76E-6 YKR089C TGL4 hom Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p
0.079 4.82E-6 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine