YPR017C / DSS4

Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR017C / DSS4

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:5.65|P-value:1.34E-8 ID:SGTC_135|Compound:0933-0004|FD-Score:5.30|P-value:9.14E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:4.15|P-value:2.23E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.86|P-value:7.45E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:4.39|P-value:7.75E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:4.92|P-value:6.46E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.43|P-value:3.86E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.28|P-value:6.51E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.10|P-value:2.84E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.32|P-value:1.10E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.46|P-value:5.72E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.81|P-value:5.37E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:5.49|P-value:3.20E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:3.79|P-value:9.63E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.61|P-value:2.89E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.19|P-value:8.84E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.53|P-value:4.20E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.56|P-value:2.37E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:6.22|P-value:4.50E-10 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.20|P-value:1.84E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:1.66E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.18|P-value:8.94E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.03|P-value:3.72E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.53|P-value:2.12E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-4.12|P-value:2.02E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.16|P-value:8.00E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.32|P-value:5.55E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.86|P-value:5.96E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.44|P-value:3.00E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:-3.48|P-value:2.58E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.37|P-value:3.88E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.59|P-value:3.20E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.45|P-value:2.91E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.29|P-value:6.33E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.26|P-value:7.01E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.42|P-value:3.99E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.31|P-value:5.71E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.99|P-value:4.37E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_2311|Compound:7694451|FD-Score:5.76|P-value:6.79E-9 ID:SGTC_2458|Compound:5808907|FD-Score:3.19|P-value:8.72E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.16|P-value:8.01E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.26|P-value:6.91E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.19|P-value:8.84E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.91|P-value:6.04E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.93|P-value:4.50E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.58|P-value:2.22E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.97|P-value:5.11E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.81|P-value:1.11E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.39|P-value:3.61E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.22|P-value:4.49E-10 ID:SGTC_3203|Compound:9113543|FD-Score:4.52|P-value:4.37E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.41|P-value:7.15E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:5.65|P-value:1.34E-8 ID:SGTC_135|Compound:0933-0004|FD-Score:5.30|P-value:9.14E-8 ID:SGTC_147|Compound:4466-0538|FD-Score:4.15|P-value:2.23E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.86|P-value:7.45E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:4.39|P-value:7.75E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:4.92|P-value:6.46E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:3.43|P-value:3.86E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.28|P-value:6.51E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.10|P-value:2.84E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.32|P-value:1.10E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.46|P-value:5.72E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.81|P-value:5.37E-9 ID:SGTC_794|Compound:k038-0031|FD-Score:3.61|P-value:1.99E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:5.49|P-value:3.20E-8 ID:SGTC_846|Compound:0335-0850|FD-Score:3.79|P-value:9.63E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.61|P-value:2.89E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.19|P-value:8.84E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.53|P-value:4.20E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.56|P-value:2.37E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.76|P-value:1.12E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:6.22|P-value:4.50E-10 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.20|P-value:1.84E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:1.66E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.18|P-value:8.94E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.03|P-value:3.72E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.53|P-value:2.12E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-4.12|P-value:2.02E-5 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.16|P-value:8.00E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.32|P-value:5.55E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:-3.86|P-value:5.96E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.44|P-value:3.00E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:-3.48|P-value:2.58E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.37|P-value:3.88E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.59|P-value:3.20E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-3.51|P-value:2.26E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.45|P-value:2.91E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.29|P-value:6.33E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.26|P-value:7.01E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.42|P-value:3.99E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.31|P-value:5.71E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.99|P-value:4.37E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_2311|Compound:7694451|FD-Score:5.76|P-value:6.79E-9 ID:SGTC_2458|Compound:5808907|FD-Score:3.19|P-value:8.72E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-3.16|P-value:8.01E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.26|P-value:6.91E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.19|P-value:8.84E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.91|P-value:6.04E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.93|P-value:4.50E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.58|P-value:2.22E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.97|P-value:5.11E-7 ID:SGTC_2990|Compound:9074105|FD-Score:3.40|P-value:4.18E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.81|P-value:1.11E-6 ID:SGTC_3133|Compound:9127736|FD-Score:-3.39|P-value:3.61E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.22|P-value:4.49E-10 ID:SGTC_3203|Compound:9113543|FD-Score:4.52|P-value:4.37E-6 ID:SGTC_3212|Compound:9128307|FD-Score:4.41|P-value:7.15E-6

Top fitness defect scores for YPR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 6.22 49.5 µM 4.49E-10 10 2.53E-10
2 SGTC_1219 1469-0211 6.22 33.1 µM 4.50E-10 9 2.54E-10
3 SGTC_773 4358-1457 5.81 44.6 µM 5.37E-9 14 3.22E-9
4 SGTC_2311 7694451 5.76 200.0 µM 6.79E-9 4 4.09E-9
5 SGTC_132 0417-1715 5.65 25.8 µM 1.34E-8 RPP1 & pyrimidine depletion 5 8.20E-9
6 SGTC_812 4251-0442 5.49 148.0 µM 3.20E-8 3 2.00E-8
7 SGTC_135 0933-0004 5.30 26.4 µM 9.14E-8 60S ribosome export 5 5.87E-8
8 SGTC_2952 9073731 4.97 13.8 µM 5.11E-7 tubulin folding & SWR complex 15 3.43E-7
9 SGTC_284 0988-0104 4.92 32.6 µM 6.46E-7 heme requiring 4 4.36E-7
10 SGTC_3019 9081971 4.81 49.5 µM 1.11E-6 9 7.58E-7
11 SGTC_849 0386-0493 4.61 241.0 µM 2.89E-6 6 2.03E-6
12 SGTC_1633 st005664 4.59 67.9 µM 3.20E-6 17 2.25E-6
13 SGTC_918 glabranin 4.53 770.7 nM 4.20E-6 19 2.97E-6
14 SGTC_3203 9113543 4.52 49.5 µM 4.37E-6 20 3.10E-6
15 SGTC_599 1935-0052 4.46 86.5 µM 5.72E-6 11 4.08E-6
16 SGTC_3212 9128307 4.41 49.5 µM 7.15E-6 31 5.12E-6
17 SGTC_280 3448-3607 4.39 3.0 µM 7.75E-6 60S ribosome export 2 5.57E-6
18 SGTC_588 3970-1144 4.32 52.9 µM 1.10E-5 21 7.96E-6
19 SGTC_1224 0823-0416 4.20 294.0 µM 1.84E-5 3 1.35E-5
20 SGTC_147 4466-0538 4.15 29.2 µM 2.23E-5 ergosterol biosynthesis 12 1.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.83E-11 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.100 5.78E-9 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.096 2.91E-8 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.091 1.49E-7 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.090 1.60E-7 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.088 3.26E-7 YLR118C YLR118C hom Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
0.087 4.30E-7 YPR171W BSP1 hom Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
0.086 6.50E-7 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.081 2.77E-6 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.080 3.42E-6 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.079 4.51E-6 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.078 6.31E-6 YER175W-A_p YER175W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.075 1.38E-5 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.075 1.52E-5 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.073 2.16E-5 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci