YPR020W / ATP20

Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR020W / ATP20

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.83|P-value:5.06E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.10|P-value:1.27E-7 ID:SGTC_605|Compound:1315-0399|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.22|P-value:5.65E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.36|P-value:3.46E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.06|P-value:9.77E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.08|P-value:9.07E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.38|P-value:3.17E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.77|P-value:6.97E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.09|P-value:8.71E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.93|P-value:3.40E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.68|P-value:9.76E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.43|P-value:2.61E-4 ID:SGTC_1518|Compound:st038567|FD-Score:5.11|P-value:1.14E-7 ID:SGTC_1522|Compound:st012842|FD-Score:3.58|P-value:1.45E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1607|Compound:st000305|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_1778|Compound:st046819|FD-Score:-3.24|P-value:5.21E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.17|P-value:6.67E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.28|P-value:4.42E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:3.64E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.58|P-value:1.81E-6 ID:SGTC_2311|Compound:7694451|FD-Score:-3.18|P-value:6.45E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.17|P-value:6.66E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-4.00|P-value:2.65E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.19|P-value:6.23E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.08|P-value:1.80E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.26|P-value:4.88E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.09|P-value:1.27E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.32|P-value:3.87E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.13|P-value:1.44E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.07|P-value:9.38E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.44|P-value:2.50E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.83|P-value:5.06E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-5.10|P-value:1.27E-7 ID:SGTC_605|Compound:1315-0399|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.22|P-value:5.65E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.36|P-value:3.46E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.06|P-value:9.77E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.08|P-value:9.07E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.38|P-value:3.17E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.77|P-value:6.97E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.09|P-value:8.71E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.93|P-value:3.40E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.68|P-value:9.76E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.43|P-value:2.61E-4 ID:SGTC_1518|Compound:st038567|FD-Score:5.11|P-value:1.14E-7 ID:SGTC_1522|Compound:st012842|FD-Score:3.58|P-value:1.45E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_1607|Compound:st000305|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_1778|Compound:st046819|FD-Score:-3.24|P-value:5.21E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-3.17|P-value:6.67E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.28|P-value:4.42E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.34|P-value:3.64E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.58|P-value:1.81E-6 ID:SGTC_2311|Compound:7694451|FD-Score:-3.18|P-value:6.45E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.17|P-value:6.66E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-4.00|P-value:2.65E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.10|P-value:8.80E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.19|P-value:6.23E-4 ID:SGTC_2699|Compound:st077704|FD-Score:4.08|P-value:1.80E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.19|P-value:6.15E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.26|P-value:4.88E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.09|P-value:1.27E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.32|P-value:3.87E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.56|P-value:1.57E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.13|P-value:1.44E-5

Top fitness defect scores for YPR020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1518 st038567 5.11 90.8 µM 1.14E-7 7 1.59E-7
2 SGTC_2760 etidronate 5.09 98.0 µM 1.27E-7 9 1.75E-7
3 SGTC_427 1354-0053 4.83 47.3 µM 5.06E-7 8 6.80E-7
4 SGTC_1352 1496-0991 4.77 99.0 µM 6.97E-7 tubulin folding & SWR complex 14 9.30E-7
5 SGTC_2066 5222451 4.58 176.0 µM 1.81E-6 heme biosynthesis & mitochondrial translocase 17 2.37E-6
6 SGTC_2885 9057732 4.13 52.0 µM 1.44E-5 11 1.79E-5
7 SGTC_2699 st077704 4.08 54.6 µM 1.80E-5 endomembrane recycling 47 2.23E-5
8 SGTC_1607 st000305 4.06 50.6 µM 2.02E-5 9 2.51E-5
9 SGTC_1543 azetidyl-2-carboxylic acid 4.00 198.0 µM 2.59E-5 12 3.19E-5
10 SGTC_1385 3091-4834 3.93 14.1 µM 3.40E-5 RPP1 & pyrimidine depletion 22 4.16E-5
11 SGTC_1479 0549-0158 3.68 134.0 µM 9.76E-5 36 1.17E-4
12 SGTC_1942 st076330 3.63 65.2 µM 1.17E-4 36 1.40E-4
13 SGTC_1522 st012842 3.58 45.6 µM 1.45E-4 RNA pol III & RNase P/MRP 38 1.72E-4
14 SGTC_873 0591-4978 3.56 488.0 µM 1.57E-4 25 1.85E-4
15 SGTC_2884 9058502 3.56 52.0 µM 1.57E-4 39 1.86E-4
16 SGTC_1406 3909-7906 3.54 11.9 µM 1.69E-4 60S ribosome export 19 2.00E-4
17 SGTC_2395 5646831 3.52 180.2 µM 1.83E-4 42 2.16E-4
18 SGTC_1377 2944-0135 3.48 198.0 µM 2.17E-4 calcium & mitochondrial duress 52 2.55E-4
19 SGTC_69 0096-0274 3.44 206.7 µM 2.50E-4 mitochondrial processes 72 2.92E-4
20 SGTC_1300 1094-0077 3.38 113.0 µM 3.17E-4 26 3.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.04E-10 YMR285C NGL2 hom Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.105 9.83E-10 YBR215W HPC2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
0.087 4.74E-7 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.075 1.24E-5 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.074 1.79E-5 YIL009C-A EST3 hom Component of the telomerase holoenzyme, involved in telomere replication
0.073 2.31E-5 YBR105C VID24 hom GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
0.073 2.33E-5 YDR216W ADR1 hom Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
0.072 2.80E-5 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.072 3.18E-5 YDR532C KRE28 hom Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.071 3.55E-5 YCR091W KIN82 hom Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
0.070 5.03E-5 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.069 5.79E-5 YBR119W MUD1 hom U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
0.069 7.07E-5 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.066 1.42E-4 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.065 1.78E-4 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance