YPR021C / AGC1

Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR021C / AGC1

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:4.81|P-value:1.12E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.36|P-value:4.92E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.14|P-value:2.36E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.61|P-value:2.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.47|P-value:2.90E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.43|P-value:3.37E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-3.28|P-value:5.67E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.71|P-value:1.35E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.21|P-value:8.19E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.15|P-value:8.81E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.50|P-value:4.95E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:1.95E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.47|P-value:3.31E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.82|P-value:1.09E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.33|P-value:5.40E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.19|P-value:8.86E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:5.19|P-value:1.69E-7 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.04|P-value:3.60E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.19|P-value:1.88E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.28|P-value:1.07E-7 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.46|P-value:3.43E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.34|P-value:5.15E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-3.42|P-value:3.51E-4 ID:SGTC_1642|Compound:st009582|FD-Score:6.47|P-value:9.77E-11 ID:SGTC_1657|Compound:st012939|FD-Score:3.83|P-value:8.59E-5 ID:SGTC_1661|Compound:st013063|FD-Score:7.17|P-value:8.44E-13 ID:SGTC_1665|Compound:st014639|FD-Score:5.07|P-value:3.09E-7 ID:SGTC_1676|Compound:st018489|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.77|P-value:1.07E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.66|P-value:1.62E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.46|P-value:5.09E-6 ID:SGTC_1983|Compound:st071813|FD-Score:5.07|P-value:3.10E-7 ID:SGTC_1993|Compound:st073995|FD-Score:-3.32|P-value:4.98E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.43|P-value:3.39E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.10|P-value:2.82E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.26|P-value:6.81E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.79|P-value:1.00E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.59|P-value:3.18E-6 ID:SGTC_2376|Compound:9072922|FD-Score:3.52|P-value:2.76E-4 ID:SGTC_2377|Compound:9073351|FD-Score:6.02|P-value:1.61E-9 ID:SGTC_2390|Compound:9097792|FD-Score:4.54|P-value:4.00E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2461|Compound:5755302|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.62|P-value:1.89E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.21|P-value:1.29E-7 ID:SGTC_2716|Compound:st080858|FD-Score:4.33|P-value:1.06E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.77|P-value:1.05E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.31|P-value:5.74E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.25|P-value:7.08E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.09|P-value:2.96E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.06|P-value:3.31E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.70|P-value:1.42E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.34|P-value:1.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.87|P-value:7.27E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.47|P-value:3.26E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.81|P-value:1.12E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:3.44|P-value:3.67E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.36|P-value:4.92E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.14|P-value:2.36E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.61|P-value:2.00E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.47|P-value:2.90E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.43|P-value:3.37E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:-3.28|P-value:5.67E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.71|P-value:1.35E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.72|P-value:1.29E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.21|P-value:8.19E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.15|P-value:8.81E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.50|P-value:4.95E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:1.95E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.47|P-value:3.31E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.82|P-value:1.09E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:3.33|P-value:5.40E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.19|P-value:8.86E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:5.19|P-value:1.69E-7 ID:SGTC_971|Compound:1315-0384|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.04|P-value:3.60E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.19|P-value:1.88E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.28|P-value:1.07E-7 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.46|P-value:3.43E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.34|P-value:5.15E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-3.42|P-value:3.51E-4 ID:SGTC_1642|Compound:st009582|FD-Score:6.47|P-value:9.77E-11 ID:SGTC_1657|Compound:st012939|FD-Score:3.83|P-value:8.59E-5 ID:SGTC_1661|Compound:st013063|FD-Score:7.17|P-value:8.44E-13 ID:SGTC_1665|Compound:st014639|FD-Score:5.07|P-value:3.09E-7 ID:SGTC_1676|Compound:st018489|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.16|P-value:9.74E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.77|P-value:1.07E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.66|P-value:1.62E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-4.46|P-value:5.09E-6 ID:SGTC_1983|Compound:st071813|FD-Score:5.07|P-value:3.10E-7 ID:SGTC_1993|Compound:st073995|FD-Score:-3.32|P-value:4.98E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.43|P-value:3.39E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.10|P-value:2.82E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.26|P-value:6.81E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.28|P-value:6.52E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.79|P-value:1.00E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.71|P-value:1.33E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.59|P-value:3.18E-6 ID:SGTC_2376|Compound:9072922|FD-Score:3.52|P-value:2.76E-4 ID:SGTC_2377|Compound:9073351|FD-Score:6.02|P-value:1.61E-9 ID:SGTC_2390|Compound:9097792|FD-Score:4.54|P-value:4.00E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.61|P-value:3.00E-6 ID:SGTC_2461|Compound:5755302|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.62|P-value:1.89E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.21|P-value:1.29E-7 ID:SGTC_2716|Compound:st080858|FD-Score:4.33|P-value:1.06E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.77|P-value:1.05E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.31|P-value:5.74E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.25|P-value:7.08E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.09|P-value:2.96E-5 ID:SGTC_2953|Compound:9074162|FD-Score:4.06|P-value:3.31E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.70|P-value:1.42E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.34|P-value:1.01E-5 ID:SGTC_3199|Compound:9111318|FD-Score:3.87|P-value:7.27E-5 ID:SGTC_3237|Compound:9133362|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.47|P-value:3.26E-4

Top fitness defect scores for YPR021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1661 st013063 7.17 9.7 µM 8.44E-13 4 3.70E-13
2 SGTC_1642 st009582 6.47 77.7 µM 9.77E-11 RPP1 & pyrimidine depletion 2 4.93E-11
3 SGTC_2377 9073351 6.02 62.6 µM 1.61E-9 ergosterol biosynthesis 5 8.80E-10
4 SGTC_1166 k206-0078 5.28 225.0 µM 1.07E-7 6 6.63E-8
5 SGTC_954 1189-0853 5.19 2.9 µM 1.69E-7 endomembrane recycling 16 1.06E-7
6 SGTC_1665 st014639 5.07 11.4 µM 3.09E-7 NEO1 11 1.98E-7
7 SGTC_1983 st071813 5.07 46.9 µM 3.10E-7 RPP1 & pyrimidine depletion 6 1.99E-7
8 SGTC_687 k029-0044 4.82 34.9 µM 1.09E-6 PDR1 9 7.26E-7
9 SGTC_115 0527-0192 4.81 112.0 µM 1.12E-6 38 7.49E-7
10 SGTC_682 0kpi-0099 4.70 17.0 µM 1.95E-6 45 1.32E-6
11 SGTC_2430 5571206 4.61 200.0 µM 3.00E-6 39 2.06E-6
12 SGTC_2300 7976697 4.59 71.6 µM 3.18E-6 ERG2 18 2.19E-6
13 SGTC_2390 9097792 4.54 176.6 µM 4.00E-6 5 2.77E-6
14 SGTC_680 0417-1641 4.50 114.0 µM 4.95E-6 RPP1 & pyrimidine depletion 5 3.45E-6
15 SGTC_3049 9092223 4.34 49.5 µM 1.01E-5 12 7.19E-6
16 SGTC_2716 st080858 4.33 38.6 µM 1.06E-5 60S ribosome export 11 7.53E-6
17 SGTC_1132 3456-3614 4.19 2.5 µM 1.88E-5 tubulin folding & SWR complex 34 1.37E-5
18 SGTC_355 1311-2252 4.14 105.0 µM 2.36E-5 13 1.73E-5
19 SGTC_2019 4016004 4.10 108.0 µM 2.82E-5 26 2.07E-5
20 SGTC_2841 9004761 4.09 39.0 µM 2.96E-5 amide catabolism 24 2.18E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.90E-11 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.110 1.71E-10 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.106 8.46E-10 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.100 6.24E-9 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.098 1.28E-8 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.097 1.64E-8 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.095 3.06E-8 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.092 9.05E-8 YNL049C SFB2 hom Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p
0.087 4.23E-7 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.084 1.20E-6 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.083 1.33E-6 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.083 1.56E-6 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.081 2.90E-6 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.080 3.59E-6 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.079 4.04E-6 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications