YPR022C_p

Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR022C / YPR022C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.31|P-value:1.39E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.32|P-value:6.24E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.90|P-value:6.46E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.21|P-value:9.13E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.83|P-value:8.66E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.66|P-value:1.90E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.19|P-value:2.33E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.10|P-value:3.45E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.59|P-value:2.45E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.69|P-value:1.71E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:7.75|P-value:2.08E-14 ID:SGTC_1588|Compound:farnesol|FD-Score:3.67|P-value:1.80E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.95|P-value:6.25E-5 ID:SGTC_1628|Compound:st004252|FD-Score:4.41|P-value:9.02E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.88|P-value:8.18E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.44|P-value:4.15E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.25|P-value:8.02E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.15|P-value:9.75E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.63|P-value:1.85E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.19|P-value:9.74E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.02|P-value:4.58E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.31|P-value:1.39E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.32|P-value:6.24E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.90|P-value:6.46E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.21|P-value:9.13E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.83|P-value:8.66E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.66|P-value:1.90E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.19|P-value:2.33E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:5.10|P-value:3.45E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.59|P-value:2.45E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.69|P-value:1.71E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:7.75|P-value:2.08E-14 ID:SGTC_1588|Compound:farnesol|FD-Score:3.67|P-value:1.80E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.95|P-value:6.25E-5 ID:SGTC_1628|Compound:st004252|FD-Score:4.41|P-value:9.02E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.88|P-value:8.18E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.44|P-value:4.15E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.25|P-value:8.02E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.15|P-value:9.75E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.63|P-value:1.85E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.19|P-value:9.74E-4 ID:SGTC_2591|Compound:skatole|FD-Score:4.02|P-value:4.58E-5

Top fitness defect scores for YPR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1564 D-Arginine 7.75 115.0 µM 2.08E-14 4 4.46E-15
2 SGTC_868 0527-0199 5.10 213.0 µM 3.45E-7 fatty acid desaturase (OLE1) 14 1.69E-7
3 SGTC_1628 st004252 4.41 77.7 µM 9.02E-6 11 5.22E-6
4 SGTC_6 0844-0013 4.31 19.8 µM 1.39E-5 62 8.23E-6
5 SGTC_823 0417-1665 4.19 178.0 µM 2.33E-5 34 1.41E-5
6 SGTC_2591 skatole 4.02 100.0 µM 4.58E-5 28 2.88E-5
7 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.95 54.9 µM 6.25E-5 redox potentiating 56 3.99E-5
8 SGTC_1629 st005085 3.88 44.9 µM 8.18E-5 RPP1 & pyrimidine depletion 39 5.29E-5
9 SGTC_1477 0139-0234 3.69 16.0 µM 1.69E-4 11 1.14E-4
10 SGTC_1228 0124-0032 3.69 52.5 µM 1.71E-4 24 1.14E-4
11 SGTC_1588 farnesol 3.67 29.9 µM 1.80E-4 15 1.21E-4
12 SGTC_405 ebelactone b 3.66 50.0 µM 1.90E-4 24 1.28E-4
13 SGTC_1123 mangostin 3.59 811.3 nM 2.45E-4 mitochondrial response to ROS 49 1.67E-4
14 SGTC_1684 st024538 3.44 14.6 µM 4.15E-4 14 2.91E-4
15 SGTC_17 0960-0276 3.32 49.8 µM 6.24E-4 66 4.46E-4
16 SGTC_2031 5180455 3.25 200.0 µM 8.02E-4 30 5.81E-4
17 SGTC_137 0438-0332 3.21 85.4 µM 9.13E-4 ubiquinone biosynthesis & proteasome 170 6.66E-4
18 SGTC_2498 4'-Methoxychalcone 3.19 54.6 µM 9.74E-4 RPP1 & pyrimidine depletion 64 7.13E-4
19 SGTC_119 0121-0043 3.15 24.8 µM 0.00112 mitochondrial stress 183 8.25E-4
20 SGTC_260 nsc-65238 3.07 4.0 µM 0.00142 endomembrane recycling 41 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.28E-18 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.136 2.37E-15 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.134 5.59E-15 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.125 3.81E-13 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.122 1.27E-12 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
0.118 6.19E-12 YPR030W CSR2 hom Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication
0.108 3.54E-10 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.103 2.13E-9 YOR124C UBP2 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
0.102 2.63E-9 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.102 2.71E-9 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.097 1.62E-8 YOL052C-A DDR2 hom Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
0.097 1.78E-8 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.095 3.48E-8 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.091 1.20E-7 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.091 1.46E-7 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A