YPR023C / EAF3

Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR023C / EAF3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.39|P-value:7.03E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:6.49|P-value:5.29E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:5.00|P-value:1.92E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:2.81|P-value:9.75E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.35|P-value:8.83E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.44|P-value:5.45E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:2.90|P-value:7.04E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.27|P-value:1.83E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.53|P-value:5.26E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.15|P-value:2.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.11|P-value:3.54E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.00|P-value:5.50E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-7.61|P-value:4.66E-17 ID:SGTC_651|Compound:3253-0966|FD-Score:2.83|P-value:9.20E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:5.62E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.29|P-value:1.72E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.10|P-value:3.65E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.42|P-value:9.82E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.72|P-value:1.06E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.62|P-value:3.34E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.87|P-value:8.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.23|P-value:2.00E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.09|P-value:3.36E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.61|P-value:4.25E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.47|P-value:4.60E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.22|P-value:2.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.92|P-value:7.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.42|P-value:9.80E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.50|P-value:6.93E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.95|P-value:6.56E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.76|P-value:1.81E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.08|P-value:3.95E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.11|P-value:3.66E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.04|P-value:4.05E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.05|P-value:4.51E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.10|P-value:3.16E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.51|P-value:5.69E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.12|P-value:2.99E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.24|P-value:1.82E-4 ID:SGTC_2359|Compound:9039622|FD-Score:9.84|P-value:1.76E-27 ID:SGTC_2363|Compound:9053361|FD-Score:7.28|P-value:6.70E-16 ID:SGTC_2364|Compound:9055074|FD-Score:2.90|P-value:6.95E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-4.73|P-value:1.25E-7 ID:SGTC_2366|Compound:9070441|FD-Score:-8.18|P-value:1.90E-19 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.96|P-value:6.37E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.63|P-value:1.76E-13 ID:SGTC_2625|Compound:euphol|FD-Score:3.94|P-value:7.28E-6 ID:SGTC_3124|Compound:9127567|FD-Score:2.83|P-value:9.02E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.87|P-value:8.88E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.81|P-value:1.67E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.25|P-value:2.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.05|P-value:4.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.39|P-value:7.03E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:6.49|P-value:5.29E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:5.00|P-value:1.92E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:3.03|P-value:4.28E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:2.81|P-value:9.75E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.35|P-value:8.83E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:4.44|P-value:5.45E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:2.90|P-value:7.04E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.27|P-value:1.83E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.53|P-value:5.26E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.15|P-value:2.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.11|P-value:3.54E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.00|P-value:5.50E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-7.61|P-value:4.66E-17 ID:SGTC_651|Compound:3253-0966|FD-Score:2.83|P-value:9.20E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.96|P-value:5.62E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.29|P-value:1.72E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.10|P-value:3.65E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.42|P-value:9.82E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.72|P-value:1.06E-7 ID:SGTC_928|Compound:2764-0428|FD-Score:3.62|P-value:3.34E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.19|P-value:2.20E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.87|P-value:8.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.23|P-value:2.00E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.09|P-value:3.36E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.61|P-value:4.25E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.47|P-value:4.60E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.22|P-value:2.23E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.92|P-value:7.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.42|P-value:9.80E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.50|P-value:6.93E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.95|P-value:6.56E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.76|P-value:1.81E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.08|P-value:3.95E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.11|P-value:3.66E-6 ID:SGTC_1938|Compound:st074717|FD-Score:3.04|P-value:4.05E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.05|P-value:4.51E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.10|P-value:3.16E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.51|P-value:5.69E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.12|P-value:2.99E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.24|P-value:1.82E-4 ID:SGTC_2359|Compound:9039622|FD-Score:9.84|P-value:1.76E-27 ID:SGTC_2363|Compound:9053361|FD-Score:7.28|P-value:6.70E-16 ID:SGTC_2364|Compound:9055074|FD-Score:2.90|P-value:6.95E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-4.73|P-value:1.25E-7 ID:SGTC_2366|Compound:9070441|FD-Score:-8.18|P-value:1.90E-19 ID:SGTC_2581|Compound:avocatin a|FD-Score:-2.96|P-value:6.37E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.63|P-value:1.76E-13 ID:SGTC_2625|Compound:euphol|FD-Score:3.94|P-value:7.28E-6 ID:SGTC_3124|Compound:9127567|FD-Score:2.83|P-value:9.02E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.87|P-value:8.88E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.81|P-value:1.67E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.25|P-value:2.04E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.05|P-value:4.45E-4

Top fitness defect scores for YPR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2359 9039622 9.84 200.0 µM 1.76E-27 endomembrane recycling 3 3.61E-23
2 SGTC_2363 9053361 7.28 176.0 µM 6.70E-16 Golgi 5 1.65E-13
3 SGTC_2582 agaric acid 6.63 100.0 µM 1.76E-13 redox potentiating 141 1.73E-11
4 SGTC_67 0335-0847 6.49 266.0 µM 5.29E-13 ubiquinone biosynthesis & proteasome 58 4.33E-11
5 SGTC_158 k038-0087 5.00 26.4 µM 1.92E-8 ubiquinone biosynthesis & proteasome 89 2.80E-7
6 SGTC_916 4466-0038 4.72 42.0 nM 1.06E-7 cell wall 43 1.17E-6
7 SGTC_1270 0831-1170 4.47 17.3 µM 4.60E-7 5 3.99E-6
8 SGTC_294 k038-0071 4.44 157.0 µM 5.45E-7 ubiquinone biosynthesis & proteasome 42 4.60E-6
9 SGTC_58 0957-0393 4.39 9.0 µM 7.03E-7 cell wall 336 5.69E-6
10 SGTC_279 1273-0055 4.35 2.9 µM 8.83E-7 azole & statin 33 6.89E-6
11 SGTC_603 3794-0023 4.00 45.9 µM 5.50E-6 11 3.19E-5
12 SGTC_2625 euphol 3.94 100.0 µM 7.28E-6 29 4.03E-5
13 SGTC_1569 carminic acid 3.76 40.6 µM 1.81E-5 20 8.64E-5
14 SGTC_928 2764-0428 3.62 58.7 µM 3.34E-5 cell wall 70 1.45E-4
15 SGTC_506 n9-isopropylolomoucine 3.53 153.0 µM 5.26E-5 20 2.12E-4
16 SGTC_2103 5378138 3.51 10.0 µM 5.69E-5 29 2.26E-4
17 SGTC_685 1278-0033 3.29 54.9 µM 1.49E-4 60S ribosome export 52 5.05E-4
18 SGTC_2309 7664088 3.24 163.9 µM 1.82E-4 82 6.00E-4
19 SGTC_938 3126-1755 3.19 342.0 µM 2.20E-4 32 7.03E-4
20 SGTC_514 4466-0038 3.15 2.6 nM 2.63E-4 cell wall 214 8.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 2.25E-79 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.261 2.31E-53 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.249 1.33E-48 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.246 2.50E-47 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.237 5.04E-44 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.232 3.20E-42 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.227 1.88E-40 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.212 1.79E-35 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.209 2.65E-34 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.196 2.02E-30 YLR334C_d YLR334C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
0.194 6.88E-30 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.193 2.02E-29 YKR029C SET3 hom Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
0.193 2.25E-29 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.191 6.07E-29 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.189 1.88E-28 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription