YPR024W / YME1

Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR024W / YME1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:8.82|P-value:5.13E-21 ID:SGTC_59|Compound:0330-0160|FD-Score:3.98|P-value:1.10E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.17|P-value:5.22E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.19|P-value:3.29E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:11.70|P-value:1.26E-35 ID:SGTC_67|Compound:0335-0847|FD-Score:23.00|P-value:3.04E-130 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:7.41E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.58|P-value:5.54E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:2.93|P-value:8.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:1.84E-35 ID:SGTC_163|Compound:1327-0036|FD-Score:10.60|P-value:1.27E-29 ID:SGTC_165|Compound:k038-0023|FD-Score:5.19|P-value:1.79E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:6.52|P-value:2.47E-12 ID:SGTC_216|Compound:k038-0035|FD-Score:3.17|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:5.51E-33 ID:SGTC_283|Compound:0987-0079|FD-Score:3.90|P-value:1.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.94|P-value:7.73E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:3.41|P-value:1.36E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.93|P-value:2.20E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.89|P-value:1.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.15|P-value:8.11E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.62|P-value:8.56E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.13|P-value:5.88E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:6.40|P-value:5.65E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:3.56|P-value:7.28E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.20|P-value:3.20E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.83|P-value:1.40E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:8.40|P-value:3.21E-19 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.87|P-value:1.83E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:1.88E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.03|P-value:8.75E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.34|P-value:1.92E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.67|P-value:4.60E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.81|P-value:2.49E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.38|P-value:1.51E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.31|P-value:2.26E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.32|P-value:1.94E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.15|P-value:8.17E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.41|P-value:2.06E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.27|P-value:4.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:2.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.91|P-value:1.52E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-3.01|P-value:9.15E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.01|P-value:9.92E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.29|P-value:3.30E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.95|P-value:8.07E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.19|P-value:4.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:4.57|P-value:5.74E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.35|P-value:2.58E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:5.69|P-value:7.90E-10 ID:SGTC_2393|Compound:9031399|FD-Score:3.51|P-value:9.18E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.12|P-value:4.27E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.69|P-value:3.08E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.15|P-value:4.86E-6 ID:SGTC_2441|Compound:5730946|FD-Score:3.75|P-value:3.16E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.66|P-value:4.80E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.76|P-value:2.11E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.80|P-value:2.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.81|P-value:2.41E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.57|P-value:6.99E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.62|P-value:5.54E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:9.86E-5 ID:SGTC_2973|Compound:9094665|FD-Score:2.95|P-value:7.86E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.34|P-value:1.80E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.53|P-value:8.13E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.44|P-value:1.22E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:8.82|P-value:5.13E-21 ID:SGTC_59|Compound:0330-0160|FD-Score:3.98|P-value:1.10E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.17|P-value:5.22E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.19|P-value:3.29E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:11.70|P-value:1.26E-35 ID:SGTC_67|Compound:0335-0847|FD-Score:23.00|P-value:3.04E-130 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:7.41E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.58|P-value:5.54E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:2.93|P-value:8.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:1.84E-35 ID:SGTC_163|Compound:1327-0036|FD-Score:10.60|P-value:1.27E-29 ID:SGTC_165|Compound:k038-0023|FD-Score:5.19|P-value:1.79E-8 ID:SGTC_200|Compound:k038-0079|FD-Score:6.52|P-value:2.47E-12 ID:SGTC_216|Compound:k038-0035|FD-Score:3.17|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:5.51E-33 ID:SGTC_283|Compound:0987-0079|FD-Score:3.90|P-value:1.64E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.94|P-value:7.73E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:3.41|P-value:1.36E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.93|P-value:2.20E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.89|P-value:1.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.15|P-value:8.11E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.62|P-value:8.56E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.13|P-value:5.88E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:6.40|P-value:5.65E-12 ID:SGTC_778|Compound:3456-2434|FD-Score:3.56|P-value:7.28E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.20|P-value:3.20E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.83|P-value:1.40E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:8.40|P-value:3.21E-19 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.87|P-value:1.83E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.97|P-value:1.88E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.03|P-value:8.75E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.34|P-value:1.92E-6 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.67|P-value:4.60E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.81|P-value:2.49E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.38|P-value:1.51E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.31|P-value:2.26E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.32|P-value:1.94E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.15|P-value:8.17E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.41|P-value:2.06E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.27|P-value:4.51E-6 ID:SGTC_1635|Compound:st007035|FD-Score:3.80|P-value:2.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.91|P-value:1.52E-5 ID:SGTC_1766|Compound:st045414|FD-Score:-3.01|P-value:9.15E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.01|P-value:9.92E-6 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.29|P-value:3.30E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.16|P-value:3.67E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.95|P-value:8.07E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.19|P-value:4.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:4.57|P-value:5.74E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.35|P-value:2.58E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.57|P-value:1.09E-4 ID:SGTC_2349|Compound:9023730|FD-Score:5.69|P-value:7.90E-10 ID:SGTC_2393|Compound:9031399|FD-Score:3.51|P-value:9.18E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.12|P-value:4.27E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.69|P-value:3.08E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.15|P-value:4.86E-6 ID:SGTC_2441|Compound:5730946|FD-Score:3.75|P-value:3.16E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.66|P-value:4.80E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.76|P-value:2.11E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.80|P-value:2.57E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.81|P-value:2.41E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.57|P-value:6.99E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.10|P-value:4.69E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.62|P-value:5.54E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.49|P-value:9.86E-5 ID:SGTC_2973|Compound:9094665|FD-Score:2.95|P-value:7.86E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.34|P-value:1.80E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.53|P-value:8.13E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.31|P-value:2.07E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.44|P-value:1.22E-4

Top fitness defect scores for YPR024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 23.00 266.0 µM 3.04E-130 ubiquinone biosynthesis & proteasome 2 2.02E-117
2 SGTC_64 000l-0018 11.70 272.1 µM 1.26E-35 ubiquinone biosynthesis & proteasome 31 3.97E-32
3 SGTC_158 k038-0087 11.70 26.4 µM 1.84E-35 ubiquinone biosynthesis & proteasome 22 5.55E-32
4 SGTC_236 1509-0011 11.30 5.3 µM 5.51E-33 168 9.45E-30
5 SGTC_163 1327-0036 10.60 7.5 µM 1.27E-29 12 1.01E-26
6 SGTC_36 0335-0881 8.82 14.2 µM 5.13E-21 ubiquinone biosynthesis & proteasome 27 5.61E-19
7 SGTC_852 0418-0143 8.40 439.0 µM 3.21E-19 calcium & mitochondrial duress 11 2.32E-17
8 SGTC_200 k038-0079 6.52 37.5 µM 2.47E-12 ubiquinone biosynthesis & proteasome 23 3.61E-11
9 SGTC_743 1275-0778 6.40 158.0 µM 5.65E-12 excess fatty acid 10 7.59E-11
10 SGTC_2349 9023730 5.69 187.1 µM 7.90E-10 4 6.44E-9
11 SGTC_165 k038-0023 5.19 64.4 µM 1.79E-8 ubiquinone biosynthesis & proteasome 38 1.06E-7
12 SGTC_310 1273-0058 4.94 1.1 µM 7.73E-8 mitochondrial stress 186 3.95E-7
13 SGTC_795 0685-0265 4.83 78.0 µM 1.40E-7 excess fatty acid 11 6.76E-7
14 SGTC_2541 muurolladie-3-one 4.76 83.1 µM 2.11E-7 excess fatty acid 13 9.73E-7
15 SGTC_2415 st077333 4.69 57.7 µM 3.08E-7 26 1.37E-6
16 SGTC_142 0335-0849 4.58 62.7 µM 5.54E-7 ubiquinone biosynthesis & proteasome 100 2.32E-6
17 SGTC_2176 5809774 4.57 34.0 µM 5.74E-7 mitochondrial processes 7 2.39E-6
18 SGTC_1199 1638-0010 4.34 4.5 µM 1.92E-6 endomembrane recycling 12 7.09E-6
19 SGTC_1475 4092-1048 4.31 11.7 µM 2.26E-6 plasma membrane duress 22 8.20E-6
20 SGTC_2429 5902844 4.15 64.4 µM 4.86E-6 19 1.63E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.582 1.16E-302 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.575 1.70E-294 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.573 1.40E-291 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.534 1.09E-246 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.525 3.99E-237 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.512 1.10E-223 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.490 2.38E-202 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.479 2.57E-191 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.478 9.65E-191 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.471 1.33E-184 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.464 1.54E-178 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.452 4.35E-168 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.451 1.14E-167 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.402 3.59E-130 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.393 1.64E-124 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes