HIPHOP chemogenomics database
YPR025C / CCL1 
Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR025C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.158 | 4.50E-20 | YPL036W | PMA2 | hom | Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential |
| 0.120 | 3.05E-12 | YGR292W | MAL12 | hom | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
| 0.120 | 3.53E-12 | YPR186C | PZF1 | het | Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA |
| 0.119 | 4.07E-12 | YNL097C-B_p | YNL097C-B_p | hom | Putative protein of unknown function |
| 0.116 | 1.34E-11 | YMR041C | ARA2 | hom | NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase |
| 0.115 | 2.18E-11 | YDL131W | LYS21 | hom | Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication |
| 0.114 | 3.26E-11 | YGR189C | CRH1 | hom | Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress |
| 0.111 | 1.06E-10 | YEL008W_d | YEL008W_d | hom | Hypothetical protein predicted to be involved in metabolism |
| 0.104 | 1.57E-9 | YGR264C | MES1 | het | Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs |
| 0.103 | 2.16E-9 | YKL122C | SRP21 | het | Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm |
| 0.102 | 3.48E-9 | YJR100C | AIM25 | hom | Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
| 0.099 | 8.17E-9 | YLR190W | MMR1 | hom | Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p |
| 0.098 | 1.38E-8 | YGR043C | NQM1 | hom | Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift |
| 0.096 | 2.33E-8 | YIL161W_p | YIL161W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene |
| 0.096 | 2.67E-8 | YNL134C | YNL134C | hom | Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress |