YPR025C / CCL1

Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR025C / CCL1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.14|P-value:6.60E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.02|P-value:1.87E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.27|P-value:3.64E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.24|P-value:4.03E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.12|P-value:6.18E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.90|P-value:2.53E-7 ID:SGTC_698|Compound:k064-0052|FD-Score:3.06|P-value:8.62E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.05|P-value:1.63E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.16|P-value:5.29E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.36|P-value:2.56E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.57|P-value:1.40E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.36|P-value:2.50E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.65|P-value:9.24E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.28|P-value:4.62E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.27|P-value:3.52E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.64|P-value:9.43E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.12|P-value:6.88E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.80|P-value:4.35E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.18|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.77|P-value:5.61E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.37|P-value:2.81E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.28|P-value:2.52E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-6.28|P-value:4.61E-11 ID:SGTC_2342|Compound:7990637|FD-Score:-3.38|P-value:2.32E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.36|P-value:2.58E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:2.57E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.03|P-value:9.47E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.33|P-value:4.42E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.52|P-value:1.54E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.20|P-value:4.70E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.21|P-value:5.04E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.31|P-value:4.22E-6 ID:SGTC_2975|Compound:9084847|FD-Score:5.22|P-value:4.18E-8 ID:SGTC_2989|Compound:9073649|FD-Score:9.29|P-value:6.72E-22 ID:SGTC_3067|Compound:9117431|FD-Score:3.88|P-value:3.42E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.18|P-value:5.06E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.16|P-value:8.49E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.88|P-value:3.01E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.14|P-value:6.60E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:4.02|P-value:1.87E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.27|P-value:3.64E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.24|P-value:4.03E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.12|P-value:6.18E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.90|P-value:2.53E-7 ID:SGTC_698|Compound:k064-0052|FD-Score:3.06|P-value:8.62E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.05|P-value:1.63E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.16|P-value:5.29E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.36|P-value:2.56E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.57|P-value:1.40E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.36|P-value:2.50E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.65|P-value:9.24E-7 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.28|P-value:4.62E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.27|P-value:3.52E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.64|P-value:9.43E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.12|P-value:6.88E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.80|P-value:4.35E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.18|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.77|P-value:5.61E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.37|P-value:2.81E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.28|P-value:2.52E-8 ID:SGTC_2054|Compound:5233173|FD-Score:-6.28|P-value:4.61E-11 ID:SGTC_2342|Compound:7990637|FD-Score:-3.38|P-value:2.32E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.36|P-value:2.58E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.82|P-value:3.90E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:2.57E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.03|P-value:9.47E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.33|P-value:4.42E-6 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.52|P-value:1.54E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.20|P-value:4.70E-4 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.21|P-value:5.04E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.31|P-value:4.22E-6 ID:SGTC_2975|Compound:9084847|FD-Score:5.22|P-value:4.18E-8 ID:SGTC_2989|Compound:9073649|FD-Score:9.29|P-value:6.72E-22 ID:SGTC_3067|Compound:9117431|FD-Score:3.88|P-value:3.42E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-3.18|P-value:5.06E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.16|P-value:8.49E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.88|P-value:3.01E-5

Top fitness defect scores for YPR025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2989 9073649 9.29 71.4 µM 6.72E-22 1 7.83E-21 3.26
2 SGTC_2975 9084847 5.22 53.7 µM 4.18E-8 2 8.88E-8 0.75
3 SGTC_533 1222-0222 4.90 6.7 µM 2.53E-7 PDR1 5 4.89E-7 0.37
4 SGTC_1131 3454-3128 4.65 32.3 µM 9.24E-7 8 1.67E-6 0.14
5 SGTC_1028 k015-0029 4.57 4.8 µM 1.40E-6 2 2.48E-6 0.15
6 SGTC_2415 st077333 4.33 57.7 µM 4.42E-6 13 7.38E-6 0.14
7 SGTC_1130 3454-2858 4.15 15.9 µM 1.04E-5 NEO1 11 1.67E-5 0.21
8 SGTC_754 3474-0146 4.05 171.0 µM 1.63E-5 copper-dependent oxidative stress 3 2.55E-5 0.12
9 SGTC_349 k015-0014 4.02 24.0 µM 1.87E-5 5 2.90E-5 0.05
10 SGTC_3067 9117431 3.88 49.5 µM 3.42E-5 9 5.15E-5 0.04
11 SGTC_1512 0259-0544 3.77 12.2 µM 5.61E-5 6 8.24E-5 0.04
12 SGTC_1365 1672-3266 3.64 55.4 µM 9.43E-5 9 1.35E-4 0.05
13 SGTC_2516 gossypol 3.56 71.5 µM 1.33E-4 11 1.87E-4 0.09
14 SGTC_2510 benzyl isothiocyanate 3.52 8.3 µM 1.54E-4 29 2.15E-4 0.05
15 SGTC_2736 butenafine 3.48 14.7 µM 1.83E-4 10 2.53E-4 0.03
16 SGTC_1922 5578187 3.37 25.0 µM 2.81E-4 TRP & mitochondrial translation 10 3.81E-4 0.07
17 SGTC_2731 amoxapine 3.21 43.4 µM 5.04E-4 6 6.64E-4 0.25
18 SGTC_87 0100-0052 3.14 35.5 µM 6.60E-4 33 8.57E-4 0.06
19 SGTC_1385 3091-4834 3.12 14.1 µM 6.88E-4 RPP1 & pyrimidine depletion 13 8.93E-4 0.01
20 SGTC_698 k064-0052 3.06 127.0 µM 8.62E-4 DNA damage response 10 0.00110 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 4.50E-20 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.120 3.05E-12 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.120 3.53E-12 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
0.119 4.07E-12 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.116 1.34E-11 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.115 2.18E-11 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.114 3.26E-11 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.111 1.06E-10 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.104 1.57E-9 YGR264C MES1 het Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
0.103 2.16E-9 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.102 3.48E-9 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.099 8.17E-9 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.098 1.38E-8 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.096 2.33E-8 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.096 2.67E-8 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress