YPR026W / ATH1

Acid trehalase required for utilization of extracellular trehalose

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR026W / ATH1

Click on Significant Values for Screen Details ID:SGTC_112|Compound:phenothiazine|FD-Score:3.55|P-value:6.69E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.22|P-value:3.04E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.05|P-value:5.86E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.54|P-value:8.25E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.56|P-value:7.76E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.60|P-value:4.74E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.99|P-value:7.37E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.19|P-value:3.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.80|P-value:2.62E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.02|P-value:7.97E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.97|P-value:6.91E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.53|P-value:7.55E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.43|P-value:1.15E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.81|P-value:2.54E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-2.94|P-value:9.00E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.88|P-value:9.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.07|P-value:5.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.01|P-value:6.03E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-5.02|P-value:4.49E-8 ID:SGTC_2827|Compound:7993847|FD-Score:-3.52|P-value:9.23E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-4.88|P-value:1.02E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.59|P-value:6.84E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.06|P-value:6.49E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-4.24|P-value:3.23E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.60|P-value:5.55E-5 ID:SGTC_3192|Compound:9110362|FD-Score:5.31|P-value:6.10E-9 ID:SGTC_3199|Compound:9111318|FD-Score:-3.04|P-value:6.28E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.07|P-value:5.58E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.34|P-value:1.87E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.96|P-value:8.41E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.94|P-value:8.98E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.06|P-value:5.62E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.55|P-value:6.69E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.22|P-value:3.04E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.05|P-value:5.86E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.54|P-value:8.25E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.56|P-value:7.76E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.60|P-value:4.74E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.99|P-value:7.37E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.19|P-value:3.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.80|P-value:2.62E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.02|P-value:7.97E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.97|P-value:6.91E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.53|P-value:7.55E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.43|P-value:1.15E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.07|P-value:4.75E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.81|P-value:2.54E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-2.94|P-value:9.00E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:2.88|P-value:9.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.66|P-value:4.17E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.07|P-value:5.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.01|P-value:6.03E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-5.02|P-value:4.49E-8 ID:SGTC_2827|Compound:7993847|FD-Score:-3.52|P-value:9.23E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-4.88|P-value:1.02E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.59|P-value:6.84E-5 ID:SGTC_2978|Compound:9011784|FD-Score:4.06|P-value:6.49E-6 ID:SGTC_2981|Compound:9013952|FD-Score:-4.24|P-value:3.23E-6 ID:SGTC_2989|Compound:9073649|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:3.10|P-value:4.29E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.60|P-value:5.55E-5 ID:SGTC_3192|Compound:9110362|FD-Score:5.31|P-value:6.10E-9 ID:SGTC_3199|Compound:9111318|FD-Score:-3.04|P-value:6.28E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.07|P-value:5.58E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.34|P-value:1.87E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-2.96|P-value:8.41E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.94|P-value:8.98E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.06|P-value:5.62E-4

Top fitness defect scores for YPR026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3192 9110362 5.31 49.5 µM 6.10E-9 mitochondrial processes 1 5.49E-8
2 SGTC_2978 9011784 4.06 43.0 µM 6.49E-6 24 2.46E-5
3 SGTC_1170 0310-0127 4.02 64.8 µM 7.97E-6 25 2.94E-5
4 SGTC_2690 usnic acid 3.66 100.0 µM 4.17E-5 35 1.25E-4
5 SGTC_3161 9100388 3.60 49.5 µM 5.55E-5 iron homeostasis 12 1.61E-4
6 SGTC_112 phenothiazine 3.55 287.2 µM 6.69E-5 unfolded protein response 20 1.90E-4
7 SGTC_1262 0737-0114 3.53 49.6 µM 7.55E-5 33 2.11E-4
8 SGTC_1347 1493-0251 3.43 600.0 nM 1.15E-4 mitochondrial response to ROS 29 3.06E-4
9 SGTC_2279 7948423 3.29 32.9 µM 1.99E-4 28 4.93E-4
10 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.23 92.6 µM 2.55E-4 53 6.15E-4
11 SGTC_3064 1327-0027 3.10 10.0 µM 4.29E-4 21 9.71E-4
12 SGTC_2989 9073649 3.09 71.4 µM 4.44E-4 89 9.99E-4
13 SGTC_1377 2944-0135 3.07 198.0 µM 4.75E-4 calcium & mitochondrial duress 84 0.00106
14 SGTC_2724 maprotiline 3.01 69.6 µM 6.03E-4 ERG2 50 0.00131
15 SGTC_1256 0570-0116 2.97 285.0 µM 6.91E-4 60 0.00147
16 SGTC_2546 rhodinyl acetate 2.88 100.0 µM 9.81E-4 55 0.00201
17 SGTC_3186 9110464 2.84 49.5 µM 0.00111 RPP1 & pyrimidine depletion 49 0.00224
18 SGTC_1008 4106-0037 2.79 6.0 µM 0.00133 PDR1 60 0.00262
19 SGTC_949 1165-0505 2.79 146.0 µM 0.00135 92 0.00266
20 SGTC_947 3447-0010 2.67 211.0 µM 0.00205 89 0.00384

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 6.05E-29 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.170 3.94E-23 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.165 5.53E-22 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.158 3.35E-20 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein
0.149 4.89E-18 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.140 3.91E-16 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.135 4.98E-15 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.134 8.16E-15 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.131 2.46E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.129 6.30E-14 YKL141W SDH3 het Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.126 2.44E-13 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.124 5.78E-13 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.123 7.06E-13 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.123 8.80E-13 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.120 2.56E-12 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels