YPR027C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR027C / YPR027C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.70|P-value:4.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.23|P-value:6.90E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.46|P-value:8.90E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.69|P-value:4.31E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.65|P-value:5.65E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.47|P-value:8.77E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:7.29|P-value:2.77E-11 ID:SGTC_909|Compound:3448-9333|FD-Score:3.70|P-value:4.25E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.81|P-value:7.41E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:9.10E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.26|P-value:1.10E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.98|P-value:1.67E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.12|P-value:1.01E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.78|P-value:3.30E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.46|P-value:8.84E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.58|P-value:1.84E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:3.70E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.13|P-value:9.75E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.16|P-value:8.92E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:6.13|P-value:1.71E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.74|P-value:3.67E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:8.42|P-value:1.82E-14 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.44|P-value:9.43E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.02|P-value:1.44E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:6.59|P-value:1.48E-9 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.53|P-value:8.21E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.00|P-value:3.27E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.40|P-value:5.81E-7 ID:SGTC_1516|Compound:st013856|FD-Score:3.55|P-value:6.88E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.01|P-value:1.44E-10 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.49|P-value:8.06E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.91|P-value:4.77E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.44|P-value:9.50E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.60|P-value:1.68E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.44|P-value:3.20E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.48|P-value:8.40E-4 ID:SGTC_1943|Compound:st076331|FD-Score:4.71|P-value:1.10E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.79|P-value:3.14E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.29|P-value:5.41E-5 ID:SGTC_2072|Compound:5231554|FD-Score:5.56|P-value:2.70E-7 ID:SGTC_2087|Compound:5276107|FD-Score:4.60|P-value:1.71E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.65|P-value:4.93E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.44|P-value:9.67E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.50|P-value:2.48E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.71|P-value:1.33E-7 ID:SGTC_2694|Compound:st077685|FD-Score:3.99|P-value:1.63E-4 ID:SGTC_2832|Compound:7992762|FD-Score:6.29|P-value:7.57E-9 ID:SGTC_2855|Compound:9016525|FD-Score:3.43|P-value:9.89E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.64|P-value:5.07E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.69|P-value:4.38E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.70|P-value:4.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.23|P-value:6.90E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:3.46|P-value:8.90E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.69|P-value:4.31E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.65|P-value:5.65E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.47|P-value:8.77E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:7.29|P-value:2.77E-11 ID:SGTC_909|Compound:3448-9333|FD-Score:3.70|P-value:4.25E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.81|P-value:7.41E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.46|P-value:9.10E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.26|P-value:1.10E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.98|P-value:1.67E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.12|P-value:1.01E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.78|P-value:3.30E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.46|P-value:8.84E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.58|P-value:1.84E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:3.70E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.13|P-value:9.75E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:4.16|P-value:8.92E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:6.13|P-value:1.71E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.74|P-value:3.67E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:8.42|P-value:1.82E-14 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.44|P-value:9.43E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.02|P-value:1.44E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:6.59|P-value:1.48E-9 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.53|P-value:8.21E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.00|P-value:3.27E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.40|P-value:5.81E-7 ID:SGTC_1516|Compound:st013856|FD-Score:3.55|P-value:6.88E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.01|P-value:1.44E-10 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.49|P-value:8.06E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.91|P-value:4.77E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.44|P-value:9.50E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.60|P-value:1.68E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.44|P-value:3.20E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.48|P-value:8.40E-4 ID:SGTC_1943|Compound:st076331|FD-Score:4.71|P-value:1.10E-5 ID:SGTC_2007|Compound:4011539|FD-Score:3.79|P-value:3.14E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.29|P-value:5.41E-5 ID:SGTC_2072|Compound:5231554|FD-Score:5.56|P-value:2.70E-7 ID:SGTC_2087|Compound:5276107|FD-Score:4.60|P-value:1.71E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.65|P-value:4.93E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.44|P-value:9.67E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.50|P-value:2.48E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.71|P-value:1.33E-7 ID:SGTC_2694|Compound:st077685|FD-Score:3.99|P-value:1.63E-4 ID:SGTC_2832|Compound:7992762|FD-Score:6.29|P-value:7.57E-9 ID:SGTC_2855|Compound:9016525|FD-Score:3.43|P-value:9.89E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.64|P-value:5.07E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.69|P-value:4.38E-4

Top fitness defect scores for YPR027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1381 2324-0066 8.42 62.1 µM 1.82E-14 3 1.89E-17
2 SGTC_826 1683-5028 7.29 118.0 µM 2.77E-11 3 1.60E-13
3 SGTC_1525 8-methoxypsoralen 7.01 92.5 µM 1.44E-10 DNA damage response 5 1.22E-12
4 SGTC_1503 4585-0012 6.59 61.3 µM 1.48E-9 1 2.15E-11
5 SGTC_2832 7992762 6.29 52.0 µM 7.57E-9 5 1.61E-10
6 SGTC_1375 2910-0797 6.13 186.0 µM 1.71E-8 3 4.39E-10
7 SGTC_2597 laccaic acid a 5.71 100.0 µM 1.33E-7 8 5.49E-9
8 SGTC_2072 5231554 5.56 129.0 µM 2.70E-7 3 1.31E-8
9 SGTC_1515 3460-0031 5.40 42.1 µM 5.81E-7 DNA intercalators 2 3.36E-8
10 SGTC_1065 prochlorperazine maleate 5.26 2.5 µM 1.10E-6 1 7.36E-8
11 SGTC_1513 0337-0559 5.00 19.0 µM 3.27E-6 6 2.81E-7
12 SGTC_1600 coumarin 106 4.91 71.1 µM 4.77E-6 8 4.46E-7
13 SGTC_914 3820-6779 4.81 408.0 µM 7.41E-6 9 7.66E-7
14 SGTC_1943 st076331 4.71 65.2 µM 1.10E-5 9 1.24E-6
15 SGTC_1777 st045864 4.60 34.8 µM 1.68E-5 5 2.08E-6
16 SGTC_2087 5276107 4.60 200.0 µM 1.71E-5 10 2.13E-6
17 SGTC_1204 4049-0315 4.58 18.3 µM 1.84E-5 12 2.34E-6
18 SGTC_2592 piperlongumine 4.50 83.3 µM 2.48E-5 TSC3-RPN4 20 3.37E-6
19 SGTC_1893 st059353 4.44 36.1 µM 3.20E-5 11 4.60E-6
20 SGTC_2062 5245942 4.29 200.0 µM 5.41E-5 9 8.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.23E-11 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.095 3.01E-8 YLR311C_d YLR311C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.14E-7 YDR052C DBF4 het Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.38E-7 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.089 2.12E-7 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.085 8.18E-7 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.084 1.10E-6 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.083 1.66E-6 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
0.077 8.59E-6 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.077 8.92E-6 YDR345C HXT3 hom Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication
0.076 1.17E-5 YOL098C_p YOL098C_p hom Putative metalloprotease
0.074 1.67E-5 YLR297W YLR297W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication
0.074 1.78E-5 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.073 2.10E-5 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.073 2.25E-5 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p