YPR030W / CSR2

Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR030W / CSR2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.41|P-value:6.22E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.48|P-value:4.97E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.56|P-value:3.75E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.24|P-value:2.98E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.87|P-value:1.26E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.07|P-value:7.71E-7 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.84|P-value:1.63E-8 ID:SGTC_1078|Compound:idebenone|FD-Score:4.63|P-value:5.75E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.41|P-value:6.24E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-4.00|P-value:7.56E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.23|P-value:3.06E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.32|P-value:8.21E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.75|P-value:1.94E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.60|P-value:3.22E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.27|P-value:9.67E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.13|P-value:4.59E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.26|P-value:2.69E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-4.02|P-value:6.92E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.79|P-value:2.87E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-3.81|P-value:1.55E-4 ID:SGTC_2190|Compound:6049624|FD-Score:4.27|P-value:2.63E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.33|P-value:7.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:5.94|P-value:9.14E-9 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.81|P-value:2.68E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.32|P-value:8.38E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.20|P-value:3.50E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.41|P-value:6.22E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.48|P-value:4.97E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.56|P-value:3.75E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.24|P-value:2.98E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.87|P-value:1.26E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.07|P-value:7.71E-7 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.84|P-value:1.63E-8 ID:SGTC_1078|Compound:idebenone|FD-Score:4.63|P-value:5.75E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.41|P-value:6.24E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:-4.00|P-value:7.56E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:-4.23|P-value:3.06E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.32|P-value:8.21E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.75|P-value:1.94E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.60|P-value:3.22E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-3.27|P-value:9.67E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.13|P-value:4.59E-5 ID:SGTC_1632|Compound:st005650|FD-Score:4.26|P-value:2.69E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-4.02|P-value:6.92E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.76|P-value:1.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.79|P-value:2.87E-6 ID:SGTC_2010|Compound:4012422|FD-Score:-3.81|P-value:1.55E-4 ID:SGTC_2190|Compound:6049624|FD-Score:4.27|P-value:2.63E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.33|P-value:7.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:5.94|P-value:9.14E-9 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.81|P-value:1.53E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.53|P-value:4.17E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.81|P-value:2.68E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.32|P-value:8.38E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.20|P-value:3.50E-5

Top fitness defect scores for YPR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2585 alliin 5.94 100.0 µM 9.14E-9 6 1.40E-9
2 SGTC_1063 disulfiram 5.84 1.8 µM 1.63E-8 3 2.67E-9
3 SGTC_1062 mesoridazine 5.07 14.2 µM 7.71E-7 4 1.94E-7
4 SGTC_3325 9138760 4.81 55.2 µM 2.68E-6 Golgi 13 7.73E-7
5 SGTC_1942 st076330 4.79 65.2 µM 2.87E-6 13 8.34E-7
6 SGTC_1078 idebenone 4.63 36.1 µM 5.75E-6 Golgi 26 1.81E-6
7 SGTC_2190 6049624 4.27 200.0 µM 2.63E-5 2 9.75E-6
8 SGTC_1632 st005650 4.26 90.0 µM 2.69E-5 22 1.00E-5
9 SGTC_308 4092-1169 4.24 104.0 µM 2.98E-5 plasma membrane duress 44 1.12E-5
10 SGTC_3335 9143315 4.20 29.6 µM 3.50E-5 fatty acid desaturase (OLE1) 11 1.34E-5
11 SGTC_1628 st004252 4.13 77.7 µM 4.59E-5 16 1.81E-5
12 SGTC_827 3253-0474 3.87 693.0 µM 1.26E-4 21 5.54E-5
13 SGTC_2649 anisomycin 3.81 9.6 µM 1.53E-4 8 6.86E-5
14 SGTC_147 4466-0538 3.79 29.2 µM 1.67E-4 ergosterol biosynthesis 25 7.58E-5
15 SGTC_1859 st055998 3.76 20.0 µM 1.82E-4 28 8.36E-5
16 SGTC_1376 2910-0861 3.69 41.3 µM 2.39E-4 26 1.13E-4
17 SGTC_1477 0139-0234 3.60 16.0 µM 3.22E-4 14 1.57E-4
18 SGTC_300 r073-0011 3.56 5.0 µM 3.75E-4 32 1.86E-4
19 SGTC_3013 9080133 3.53 71.4 µM 4.17E-4 36 2.09E-4
20 SGTC_37 0566-0070 3.48 1.6 µM 4.97E-4 43 2.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.05E-15 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 6.19E-12 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.106 8.60E-10 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.103 1.89E-9 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.099 8.14E-9 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.094 5.63E-8 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.089 2.16E-7 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.089 2.48E-7 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.086 5.37E-7 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.086 5.99E-7 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.085 7.91E-7 YKR098C UBP11 hom Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.083 1.33E-6 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.083 1.59E-6 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.17E-6 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.082 2.21E-6 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme