YPR038W_d / IRC16

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR038W / IRC16

Click on Significant Values for Screen Details ID:SGTC_251|Compound:melphalan|FD-Score:3.77|P-value:5.63E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.61|P-value:1.09E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.12|P-value:1.22E-5 ID:SGTC_512|Compound:prima-1|FD-Score:3.84|P-value:4.25E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.20|P-value:8.32E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.09|P-value:8.44E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.34|P-value:4.43E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.36|P-value:2.86E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.70|P-value:7.45E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.69|P-value:7.84E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.92|P-value:2.97E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.07|P-value:1.53E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.42|P-value:1.42E-8 ID:SGTC_1602|Compound:st001878|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.21|P-value:5.52E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.89|P-value:3.35E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.78|P-value:5.96E-5 ID:SGTC_1898|Compound:st060199|FD-Score:5.55|P-value:6.82E-9 ID:SGTC_1905|Compound:st060207|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_2030|Compound:5175110|FD-Score:4.80|P-value:4.44E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.02|P-value:9.76E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.98|P-value:2.25E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.03|P-value:1.86E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:3.82E-5 ID:SGTC_2646|Compound:retinol|FD-Score:-3.10|P-value:8.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.08|P-value:1.43E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.17|P-value:5.69E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.49|P-value:9.47E-9 ID:SGTC_2926|Compound:9010726|FD-Score:3.23|P-value:4.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.08|P-value:8.93E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.15|P-value:6.94E-8 ID:SGTC_3072|Compound:9116419|FD-Score:3.18|P-value:5.62E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.89|P-value:3.33E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.36|P-value:2.82E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.97|P-value:2.70E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.06|P-value:8.45E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.80|P-value:4.91E-5 ID:SGTC_3290|Compound:9121031|FD-Score:5.04|P-value:1.27E-7 ID:SGTC_251|Compound:melphalan|FD-Score:3.77|P-value:5.63E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.61|P-value:1.09E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.12|P-value:1.22E-5 ID:SGTC_512|Compound:prima-1|FD-Score:3.84|P-value:4.25E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:3.28|P-value:3.82E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:4.20|P-value:8.32E-6 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.09|P-value:8.44E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.34|P-value:4.43E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.36|P-value:2.86E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.70|P-value:7.45E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.69|P-value:7.84E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.92|P-value:2.97E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:4.07|P-value:1.53E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.42|P-value:1.42E-8 ID:SGTC_1602|Compound:st001878|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.21|P-value:5.52E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.89|P-value:3.35E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.12|P-value:6.85E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.78|P-value:5.96E-5 ID:SGTC_1898|Compound:st060199|FD-Score:5.55|P-value:6.82E-9 ID:SGTC_1905|Compound:st060207|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_2030|Compound:5175110|FD-Score:4.80|P-value:4.44E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.10|P-value:7.26E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.02|P-value:9.76E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.19|P-value:5.33E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.98|P-value:2.25E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.03|P-value:1.86E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.86|P-value:3.82E-5 ID:SGTC_2646|Compound:retinol|FD-Score:-3.10|P-value:8.24E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.08|P-value:1.43E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.17|P-value:5.69E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.49|P-value:9.47E-9 ID:SGTC_2926|Compound:9010726|FD-Score:3.23|P-value:4.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.08|P-value:8.93E-4 ID:SGTC_3056|Compound:9094900|FD-Score:5.15|P-value:6.94E-8 ID:SGTC_3072|Compound:9116419|FD-Score:3.18|P-value:5.62E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.89|P-value:3.33E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.36|P-value:2.82E-4 ID:SGTC_3158|Compound:9100007|FD-Score:-3.97|P-value:2.70E-5 ID:SGTC_3213|Compound:9129884|FD-Score:3.06|P-value:8.45E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.80|P-value:4.91E-5 ID:SGTC_3290|Compound:9121031|FD-Score:5.04|P-value:1.27E-7

Top fitness defect scores for YPR038W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1898 st060199 5.55 18.6 µM 6.82E-9 1 1.45E-8
2 SGTC_2804 7954240 5.49 19.5 µM 9.47E-9 7 1.98E-8
3 SGTC_1574 spiramycin 5.42 23.7 µM 1.42E-8 6 2.92E-8
4 SGTC_3056 9094900 5.15 49.5 µM 6.94E-8 4 1.34E-7
5 SGTC_3290 9121031 5.04 71.4 µM 1.27E-7 2 2.39E-7
6 SGTC_2030 5175110 4.80 200.0 µM 4.44E-7 Golgi 15 7.92E-7
7 SGTC_1489 4065-0444 4.70 182.0 µM 7.45E-7 10 1.30E-6
8 SGTC_1136 pergolide 4.34 1.1 µM 4.43E-6 30 7.18E-6
9 SGTC_724 3910-0327 4.20 137.0 µM 8.32E-6 ERG2 15 1.31E-5
10 SGTC_506 n9-isopropylolomoucine 4.12 153.0 µM 1.22E-5 11 1.89E-5
11 SGTC_2697 mebhydrolin 4.08 72.4 µM 1.43E-5 NEO1 61 2.20E-5
12 SGTC_1535 tetrahydropapaveroline hydrobromide 4.07 54.3 µM 1.53E-5 RPP1 & pyrimidine depletion 9 2.36E-5
13 SGTC_2436 5633522 4.03 8.1 µM 1.86E-5 14 2.84E-5
14 SGTC_2237 6667747 3.98 47.2 µM 2.25E-5 14 3.41E-5
15 SGTC_1528 arabinosylhypoxanthine 3.92 74.6 µM 2.97E-5 20 4.45E-5
16 SGTC_3145 9085516 3.89 49.5 µM 3.33E-5 fatty acid desaturase (OLE1) 32 4.96E-5
17 SGTC_1869 3',7'-dimethoxyflavone 3.89 40.3 µM 3.35E-5 28 5.00E-5
18 SGTC_2582 agaric acid 3.86 100.0 µM 3.82E-5 redox potentiating 326 5.67E-5
19 SGTC_512 prima-1 3.84 270.0 µM 4.25E-5 DNA intercalators 28 6.27E-5
20 SGTC_3255 9139072 3.80 49.5 µM 4.91E-5 18 7.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 6.06E-12 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.109 2.18E-10 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.104 1.28E-9 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.21E-8 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.095 3.73E-8 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.094 4.40E-8 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.093 6.61E-8 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.087 3.99E-7 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.087 4.55E-7 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.087 4.99E-7 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.084 1.04E-6 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.084 1.07E-6 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.082 2.08E-6 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.082 2.12E-6 YHR001W-A QCR10 hom Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
0.081 2.41E-6 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane