YPR039W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR039W / YPR039W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:4.29|P-value:4.44E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:5.52|P-value:2.24E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.51|P-value:6.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.81|P-value:2.49E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.74|P-value:7.21E-6 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.10|P-value:8.71E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.81|P-value:2.50E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.75|P-value:6.94E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.52|P-value:1.76E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.58|P-value:5.35E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:5.04|P-value:2.03E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:6.38|P-value:2.59E-9 ID:SGTC_616|Compound:4092-0450|FD-Score:4.44|P-value:2.43E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.41|P-value:8.68E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.71|P-value:3.21E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.47|P-value:7.07E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:5.96|P-value:2.41E-8 ID:SGTC_999|Compound:4022-0066|FD-Score:3.76|P-value:2.93E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.73|P-value:3.29E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.63|P-value:1.13E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.61|P-value:4.50E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.87|P-value:1.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.80|P-value:5.63E-8 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.75|P-value:3.00E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.61|P-value:4.80E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.45|P-value:7.94E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.54|P-value:6.01E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.07|P-value:9.92E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.97|P-value:2.35E-8 ID:SGTC_1892|Compound:st058411|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.61|P-value:1.25E-5 ID:SGTC_2020|Compound:4017018|FD-Score:5.14|P-value:1.27E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.48|P-value:6.92E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.45|P-value:2.33E-5 ID:SGTC_2193|Compound:5925765|FD-Score:-4.64|P-value:1.02E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.68|P-value:3.83E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.72|P-value:3.40E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.74|P-value:3.16E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.25|P-value:4.99E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.52|P-value:6.54E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.96|P-value:1.45E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.59|P-value:4.84E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.59|P-value:5.17E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.61|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.37|P-value:3.27E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.48|P-value:7.28E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.86|P-value:2.08E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.71|P-value:3.44E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.41|P-value:9.08E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.10|P-value:9.00E-5 ID:SGTC_3011|Compound:9081274|FD-Score:5.18|P-value:1.05E-6 ID:SGTC_3045|Compound:9092950|FD-Score:3.78|P-value:2.76E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.42|P-value:2.64E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.66|P-value:4.05E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.41|P-value:9.10E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.29|P-value:4.44E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:5.52|P-value:2.24E-7 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.51|P-value:6.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.81|P-value:2.49E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.74|P-value:7.21E-6 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.10|P-value:8.71E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.81|P-value:2.50E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.75|P-value:6.94E-6 ID:SGTC_588|Compound:3970-1144|FD-Score:4.52|P-value:1.76E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:3.58|P-value:5.35E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:5.04|P-value:2.03E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:6.38|P-value:2.59E-9 ID:SGTC_616|Compound:4092-0450|FD-Score:4.44|P-value:2.43E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.41|P-value:8.68E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.71|P-value:3.21E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.47|P-value:7.07E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:5.96|P-value:2.41E-8 ID:SGTC_999|Compound:4022-0066|FD-Score:3.76|P-value:2.93E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.73|P-value:3.29E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.63|P-value:1.13E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.61|P-value:4.50E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.87|P-value:1.98E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.80|P-value:5.63E-8 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.43|P-value:8.72E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.75|P-value:3.00E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.61|P-value:4.80E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.45|P-value:7.94E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.54|P-value:6.01E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.07|P-value:9.92E-5 ID:SGTC_1674|Compound:st016616|FD-Score:5.97|P-value:2.35E-8 ID:SGTC_1892|Compound:st058411|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.61|P-value:1.25E-5 ID:SGTC_2020|Compound:4017018|FD-Score:5.14|P-value:1.27E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-3.48|P-value:6.92E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.45|P-value:2.33E-5 ID:SGTC_2193|Compound:5925765|FD-Score:-4.64|P-value:1.02E-5 ID:SGTC_2200|Compound:6600604|FD-Score:3.68|P-value:3.83E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.72|P-value:3.40E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.74|P-value:3.16E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.25|P-value:4.99E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.52|P-value:6.54E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.96|P-value:1.45E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.59|P-value:4.84E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.59|P-value:5.17E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.61|P-value:4.83E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.37|P-value:3.27E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.48|P-value:7.28E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.86|P-value:2.08E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.71|P-value:3.44E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.41|P-value:9.08E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.10|P-value:9.00E-5 ID:SGTC_3011|Compound:9081274|FD-Score:5.18|P-value:1.05E-6 ID:SGTC_3045|Compound:9092950|FD-Score:3.78|P-value:2.76E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.42|P-value:2.64E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.66|P-value:4.05E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.41|P-value:9.10E-4

Top fitness defect scores for YPR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_608 k048-0125 6.38 159.0 µM 2.59E-9 4 8.73E-11
2 SGTC_1674 st016616 5.97 23.6 µM 2.35E-8 3 1.20E-9
3 SGTC_983 1491-0821 5.96 12.2 µM 2.41E-8 2 1.23E-9
4 SGTC_1281 0884-0031 5.80 11.8 µM 5.63E-8 fatty acid desaturase (OLE1) 7 3.37E-9
5 SGTC_77 0828-0286 5.52 12.5 µM 2.24E-7 TSC3-RPN4 7 1.73E-8
6 SGTC_3011 9081274 5.18 71.4 µM 1.05E-6 2 1.08E-7
7 SGTC_2020 4017018 5.14 200.0 µM 1.27E-6 4 1.36E-7
8 SGTC_599 1935-0052 5.04 86.5 µM 2.03E-6 2 2.37E-7
9 SGTC_574 1315-0397 4.75 40.0 µM 6.94E-6 16 1.01E-6
10 SGTC_454 lyso-paf C-16 4.74 6.7 µM 7.21E-6 8 1.06E-6
11 SGTC_1081 sertraline 4.63 6.0 µM 1.13E-5 60S ribosome export 20 1.80E-6
12 SGTC_1982 st072467 4.61 71.9 µM 1.25E-5 18 2.04E-6
13 SGTC_588 3970-1144 4.52 52.9 µM 1.76E-5 18 3.04E-6
14 SGTC_605 1315-0399 4.49 119.0 µM 2.02E-5 Golgi 12 3.59E-6
15 SGTC_2092 5303694 4.45 80.7 µM 2.33E-5 TSC3-RPN4 26 4.25E-6
16 SGTC_616 4092-0450 4.44 108.0 µM 2.43E-5 7 4.48E-6
17 SGTC_3202 9113761 4.42 49.5 µM 2.64E-5 33 4.94E-6
18 SGTC_2582 agaric acid 4.37 100.0 µM 3.27E-5 redox potentiating 271 6.35E-6
19 SGTC_44 0929-0055 4.29 61.2 µM 4.44E-5 25 9.12E-6
20 SGTC_2266 7929956 4.25 200.0 µM 4.99E-5 24 1.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 9.70E-11 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.100 6.89E-9 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.099 7.71E-9 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.099 1.05E-8 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.34E-7 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.090 2.06E-7 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.089 2.19E-7 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.085 8.79E-7 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.082 2.27E-6 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.081 2.76E-6 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.080 3.84E-6 YKL106W AAT1 hom Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
0.079 4.11E-6 YIR015W RPR2 het Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
0.077 8.32E-6 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.077 8.78E-6 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.075 1.32E-5 YOR341W RPA190 het RNA polymerase I largest subunit A190