YPR040W / TIP41

Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR040W / TIP41

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:4.54|P-value:9.73E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.00|P-value:1.18E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.41|P-value:6.45E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:5.81|P-value:2.32E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.79|P-value:1.75E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.42|P-value:6.48E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.56|P-value:4.05E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.55|P-value:4.20E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:2.77E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.08|P-value:6.18E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.60|P-value:7.77E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.02|P-value:7.90E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.96|P-value:1.57E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:4.36|P-value:2.06E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.26|P-value:3.13E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.47|P-value:5.21E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.19|P-value:5.24E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:4.91|P-value:1.92E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:3.84|P-value:1.55E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.68|P-value:2.59E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.36|P-value:7.88E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.60|P-value:3.63E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.03|P-value:7.67E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.16|P-value:4.67E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.22|P-value:3.70E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.32|P-value:8.99E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.89|P-value:1.28E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:5.36|P-value:2.32E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.22|P-value:3.67E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.99|P-value:8.75E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.60|P-value:7.71E-6 ID:SGTC_1802|Compound:st050112|FD-Score:4.14|P-value:5.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.47|P-value:1.19E-5 ID:SGTC_2087|Compound:5276107|FD-Score:5.60|P-value:6.92E-8 ID:SGTC_2089|Compound:5281248|FD-Score:3.62|P-value:3.36E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.47|P-value:5.62E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.45|P-value:1.43E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.37|P-value:7.83E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.56|P-value:8.97E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.57|P-value:3.91E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.56|P-value:4.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.37|P-value:2.25E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.39|P-value:7.23E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.61|P-value:6.80E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.56|P-value:4.08E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.29|P-value:9.84E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.44|P-value:6.21E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.53|P-value:1.02E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.52|P-value:1.09E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.76|P-value:2.06E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.02|P-value:7.83E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.64|P-value:2.95E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.28|P-value:9.55E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.54|P-value:4.34E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.02|P-value:7.89E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.55|P-value:9.48E-6 ID:SGTC_3235|Compound:9132602|FD-Score:5.75|P-value:3.18E-8 ID:SGTC_3252|Compound:9135871|FD-Score:3.29|P-value:9.92E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.54|P-value:9.73E-6 ID:SGTC_53|Compound:0973-0023|FD-Score:-5.00|P-value:1.18E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.41|P-value:6.45E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:5.81|P-value:2.32E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.79|P-value:1.75E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.42|P-value:6.48E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.56|P-value:4.05E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.55|P-value:4.20E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.67|P-value:2.77E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.08|P-value:6.18E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.27|P-value:9.93E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.60|P-value:7.77E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.02|P-value:7.90E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.96|P-value:1.57E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:4.36|P-value:2.06E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.26|P-value:3.13E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:-3.47|P-value:5.21E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.19|P-value:5.24E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:4.91|P-value:1.92E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:3.84|P-value:1.55E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.68|P-value:2.59E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.36|P-value:7.88E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.60|P-value:3.63E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.03|P-value:7.67E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.16|P-value:4.67E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.22|P-value:3.70E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.32|P-value:8.99E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.89|P-value:1.28E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:5.36|P-value:2.32E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:4.22|P-value:3.67E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.99|P-value:8.75E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.82|P-value:1.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.60|P-value:7.71E-6 ID:SGTC_1802|Compound:st050112|FD-Score:4.14|P-value:5.05E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.47|P-value:1.19E-5 ID:SGTC_2087|Compound:5276107|FD-Score:5.60|P-value:6.92E-8 ID:SGTC_2089|Compound:5281248|FD-Score:3.62|P-value:3.36E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.47|P-value:5.62E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.45|P-value:1.43E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.37|P-value:7.83E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.56|P-value:8.97E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.57|P-value:3.91E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.56|P-value:4.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.37|P-value:2.25E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.39|P-value:7.23E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.61|P-value:6.80E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.56|P-value:4.08E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.29|P-value:9.84E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.44|P-value:6.21E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.53|P-value:1.02E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.52|P-value:1.09E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.76|P-value:2.06E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.02|P-value:7.83E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.64|P-value:2.95E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.28|P-value:9.55E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.54|P-value:4.34E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.02|P-value:7.89E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.77|P-value:2.00E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.55|P-value:9.48E-6 ID:SGTC_3235|Compound:9132602|FD-Score:5.75|P-value:3.18E-8 ID:SGTC_3252|Compound:9135871|FD-Score:3.29|P-value:9.92E-4

Top fitness defect scores for YPR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_92 0063-0024 5.81 660.9 µM 2.32E-8 2 3.13E-9
2 SGTC_3235 9132602 5.75 49.5 µM 3.18E-8 6 4.48E-9
3 SGTC_2087 5276107 5.60 200.0 µM 6.92E-8 2 1.07E-8
4 SGTC_2582 agaric acid 5.37 100.0 µM 2.25E-7 redox potentiating 200 4.04E-8
5 SGTC_1179 1021-1431 5.36 9.3 µM 2.32E-7 16 4.18E-8
6 SGTC_725 1497-0963 5.19 19.0 µM 5.24E-7 copper-dependent oxidative stress 9 1.04E-7
7 SGTC_673 1082-0474 4.96 110.0 µM 1.57E-6 RSC complex & mRNA processing 37 3.58E-7
8 SGTC_756 0508-1999 4.91 28.3 µM 1.92E-6 RPP1 & pyrimidine depletion 9 4.50E-7
9 SGTC_1754 st042065 4.60 16.1 µM 7.71E-6 NEO1-PIK1 147 2.14E-6
10 SGTC_612 0302-0167 4.60 22.4 µM 7.77E-6 copper-dependent oxidative stress 21 2.16E-6
11 SGTC_2434 5670830 4.56 169.9 µM 8.97E-6 14 2.54E-6
12 SGTC_3154 9100113 4.55 49.5 µM 9.48E-6 17 2.70E-6
13 SGTC_44 0929-0055 4.54 61.2 µM 9.73E-6 22 2.78E-6
14 SGTC_2867 9039098 4.53 71.4 µM 1.02E-5 iron homeostasis 20 2.92E-6
15 SGTC_2880 9042983 4.52 58.4 µM 1.09E-5 fatty acid desaturase (OLE1) 14 3.16E-6
16 SGTC_2195 6536160 4.45 144.2 µM 1.43E-5 60S ribosome export 5 4.29E-6
17 SGTC_676 falcarinol 4.36 140.0 µM 2.06E-5 44 6.46E-6
18 SGTC_706 4262-0057 4.26 46.9 µM 3.13E-5 fatty acid desaturase (OLE1) 27 1.03E-5
19 SGTC_1280 0880-0253 4.22 10.1 µM 3.67E-5 11 1.23E-5
20 SGTC_1103 duloxetine 4.22 36.1 µM 3.70E-5 23 1.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 3.36E-20 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.140 5.20E-16 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.119 4.30E-12 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.115 2.08E-11 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.113 5.87E-11 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.111 1.23E-10 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.110 1.54E-10 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.106 7.11E-10 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.106 7.48E-10 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.103 2.50E-9 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.102 3.24E-9 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.44E-9 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.102 3.75E-9 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.101 4.41E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.101 4.42E-9 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane