YPR043W / RPL43A

Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR043W / RPL43A

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:-3.36|P-value:4.79E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:2.86|P-value:9.75E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.25|P-value:2.34E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.07|P-value:4.60E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.79|P-value:1.76E-7 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.34|P-value:5.09E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.59|P-value:5.91E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:2.96|P-value:6.66E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.44|P-value:1.10E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.80|P-value:8.57E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.79|P-value:2.47E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.92|P-value:7.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.59|P-value:2.36E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.64|P-value:1.23E-9 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.70|P-value:3.60E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.34|P-value:7.85E-9 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.17|P-value:3.13E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.86|P-value:9.49E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:9.18|P-value:3.48E-22 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.86|P-value:9.77E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.05|P-value:4.94E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.94|P-value:7.29E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.52|P-value:7.84E-5 ID:SGTC_1849|Compound:st056239|FD-Score:5.46|P-value:3.67E-9 ID:SGTC_1911|Compound:st060208|FD-Score:3.29|P-value:1.97E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.01|P-value:9.00E-6 ID:SGTC_2096|Compound:5468907|FD-Score:2.85|P-value:9.86E-4 ID:SGTC_2245|Compound:6637752|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.12|P-value:3.76E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.14|P-value:2.45E-8 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.90|P-value:1.49E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.87|P-value:6.33E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.02|P-value:5.41E-4 ID:SGTC_2793|Compound:7325131|FD-Score:6.46|P-value:5.01E-12 ID:SGTC_3012|Compound:9080433|FD-Score:-3.21|P-value:8.00E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.71|P-value:3.42E-5 ID:SGTC_3196|Compound:9111891|FD-Score:3.12|P-value:3.79E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.22|P-value:7.85E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.03|P-value:5.18E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.89|P-value:8.64E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.36|P-value:4.79E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:2.86|P-value:9.75E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.25|P-value:2.34E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.07|P-value:4.60E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.79|P-value:1.76E-7 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.34|P-value:5.09E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.59|P-value:5.91E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:2.96|P-value:6.66E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.44|P-value:1.10E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.32|P-value:1.78E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.80|P-value:8.57E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.79|P-value:2.47E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.92|P-value:7.78E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.59|P-value:2.36E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.64|P-value:1.23E-9 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.70|P-value:3.60E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.34|P-value:7.85E-9 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.17|P-value:3.13E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.86|P-value:9.49E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:9.18|P-value:3.48E-22 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.86|P-value:9.77E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.05|P-value:4.94E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.94|P-value:7.29E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.52|P-value:7.84E-5 ID:SGTC_1849|Compound:st056239|FD-Score:5.46|P-value:3.67E-9 ID:SGTC_1911|Compound:st060208|FD-Score:3.29|P-value:1.97E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.01|P-value:9.00E-6 ID:SGTC_2096|Compound:5468907|FD-Score:2.85|P-value:9.86E-4 ID:SGTC_2245|Compound:6637752|FD-Score:2.94|P-value:7.23E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.12|P-value:3.76E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.14|P-value:2.45E-8 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.90|P-value:1.49E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.20|P-value:2.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.87|P-value:6.33E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.02|P-value:5.41E-4 ID:SGTC_2793|Compound:7325131|FD-Score:6.46|P-value:5.01E-12 ID:SGTC_3012|Compound:9080433|FD-Score:-3.21|P-value:8.00E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.71|P-value:3.42E-5 ID:SGTC_3196|Compound:9111891|FD-Score:3.12|P-value:3.79E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.22|P-value:7.85E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.03|P-value:5.18E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.89|P-value:8.64E-4

Top fitness defect scores for YPR043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1466 k213-0079 9.18 57.5 µM 3.48E-22 1 2.13E-20
2 SGTC_2793 7325131 6.46 81.8 µM 5.01E-12 4 5.38E-11
3 SGTC_1024 4507-0395 5.64 26.0 µM 1.23E-9 TSC3-RPN4 6 8.57E-9
4 SGTC_1849 st056239 5.46 19.2 µM 3.67E-9 RPP1 & pyrimidine depletion 3 2.35E-8
5 SGTC_1134 3477-0009 5.34 42.5 µM 7.85E-9 17 4.72E-8
6 SGTC_2540 epiandrosterone 5.14 100.0 µM 2.45E-8 31 1.34E-7
7 SGTC_274 sirtinol 4.79 40.1 µM 1.76E-7 10 8.22E-7
8 SGTC_2020 4017018 4.01 200.0 µM 9.00E-6 18 3.01E-5
9 SGTC_2559 tetrahydrosappanone a trimethyl ether 3.90 100.0 µM 1.49E-5 17 4.76E-5
10 SGTC_838 0109-0203 3.79 71.4 µM 2.47E-5 18 7.56E-5
11 SGTC_3015 9080845 3.71 49.5 µM 3.42E-5 10 1.02E-4
12 SGTC_1075 aripiprazole 3.70 15.2 µM 3.60E-5 38 1.07E-4
13 SGTC_440 fluspirilene 3.59 35.1 µM 5.91E-5 24 1.68E-4
14 SGTC_1806 st050005 3.52 60.3 µM 7.84E-5 25 2.17E-4
15 SGTC_929 2805-0021 3.49 398.0 µM 8.67E-5 19 2.37E-4
16 SGTC_1057 3448-5381 3.46 134.0 µM 1.01E-4 calcium & mitochondrial duress 36 2.73E-4
17 SGTC_644 1498-1197 3.44 63.3 µM 1.10E-4 44 2.94E-4
18 SGTC_691 1548-0686 3.32 185.0 µM 1.78E-4 69 4.57E-4
19 SGTC_1911 st060208 3.29 74.3 µM 1.97E-4 58 5.01E-4
20 SGTC_233 rapamycin 3.25 362.0 pM 2.34E-4 32 5.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.14E-10 YML009C-A_d YML009C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 8.08E-10 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.098 1.37E-8 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.095 3.02E-8 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.093 6.15E-8 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.089 2.22E-7 YLR192C HCR1 hom Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
0.083 1.65E-6 YGL104C VPS73 hom Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
0.081 2.78E-6 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.080 3.65E-6 YIR022W SEC11 het 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
0.079 4.91E-6 YOL090W MSH2 hom Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.077 7.13E-6 YDR182W-A_p YDR182W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.29E-5 YOR042W CUE5 hom Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.074 1.79E-5 YOR321W PMT3 hom Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
0.071 4.19E-5 YPR077C_d YPR077C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
0.070 4.78E-5 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats