YPR044C_d / OPI11

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR044C / OPI11

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.59|P-value:1.46E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.59|P-value:7.95E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.84|P-value:5.25E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.33|P-value:6.06E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:4.18|P-value:1.20E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.45|P-value:3.46E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-5.97|P-value:7.08E-10 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.43|P-value:2.62E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.10|P-value:8.20E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.14|P-value:7.59E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:5.04|P-value:1.73E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.77|P-value:6.94E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.63|P-value:6.36E-9 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.19|P-value:6.42E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.14|P-value:1.46E-5 ID:SGTC_1628|Compound:st004252|FD-Score:5.22|P-value:6.58E-8 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.71|P-value:9.05E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.75|P-value:7.61E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.25|P-value:8.76E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.10|P-value:1.69E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.69|P-value:8.86E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.98|P-value:2.71E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.48|P-value:2.20E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.33|P-value:3.68E-4 ID:SGTC_2427|Compound:5545055|FD-Score:5.10|P-value:1.25E-7 ID:SGTC_2430|Compound:5571206|FD-Score:-3.34|P-value:3.44E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.01|P-value:2.03E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.88|P-value:1.36E-9 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.58|P-value:8.32E-9 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.65|P-value:1.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.50|P-value:3.85E-18 ID:SGTC_2696|Compound:st077691|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.09|P-value:1.78E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.35|P-value:5.41E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.41|P-value:3.78E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.20|P-value:5.81E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.70|P-value:9.14E-5 ID:SGTC_3227|Compound:9130768|FD-Score:4.29|P-value:7.41E-6 ID:SGTC_3239|Compound:9133757|FD-Score:3.52|P-value:1.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.59|P-value:1.46E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.34|P-value:3.71E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.59|P-value:7.95E-9 ID:SGTC_118|Compound:0083-0097|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.17|P-value:6.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.84|P-value:5.25E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.33|P-value:6.06E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:4.18|P-value:1.20E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.45|P-value:3.46E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.39|P-value:3.12E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-5.97|P-value:7.08E-10 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.46|P-value:2.25E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.43|P-value:2.62E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.10|P-value:8.20E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.14|P-value:7.59E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.43|P-value:2.68E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:5.04|P-value:1.73E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.77|P-value:6.94E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.63|P-value:6.36E-9 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.19|P-value:6.42E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.14|P-value:1.46E-5 ID:SGTC_1628|Compound:st004252|FD-Score:5.22|P-value:6.58E-8 ID:SGTC_1681|Compound:tripelennamine|FD-Score:5.12|P-value:1.14E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.71|P-value:9.05E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.47|P-value:2.27E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.75|P-value:7.61E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.25|P-value:8.76E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.10|P-value:1.69E-5 ID:SGTC_2402|Compound:5553605|FD-Score:-3.69|P-value:8.86E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.98|P-value:2.71E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.48|P-value:2.20E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.33|P-value:3.68E-4 ID:SGTC_2427|Compound:5545055|FD-Score:5.10|P-value:1.25E-7 ID:SGTC_2430|Compound:5571206|FD-Score:-3.34|P-value:3.44E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.01|P-value:2.03E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.88|P-value:1.36E-9 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.58|P-value:8.32E-9 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.59|P-value:1.32E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.65|P-value:1.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.50|P-value:3.85E-18 ID:SGTC_2696|Compound:st077691|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.09|P-value:1.78E-5 ID:SGTC_2917|Compound:7979103|FD-Score:4.35|P-value:5.41E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.41|P-value:3.78E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.20|P-value:5.81E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.70|P-value:9.14E-5 ID:SGTC_3227|Compound:9130768|FD-Score:4.29|P-value:7.41E-6 ID:SGTC_3239|Compound:9133757|FD-Score:3.52|P-value:1.90E-4

Top fitness defect scores for YPR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 8.50 96.7 µM 3.85E-18 calcium & mitochondrial duress 52 9.08E-18
2 SGTC_2489 cantharidin 5.88 73.4 µM 1.36E-9 cell wall signaling 13 2.03E-9
3 SGTC_1369 1866-0067 5.63 208.0 µM 6.36E-9 RPP1 & pyrimidine depletion 12 9.15E-9
4 SGTC_78 0336-0123 5.59 156.8 µM 7.95E-9 6 1.14E-8
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.58 3.7 µM 8.32E-9 18 1.19E-8
6 SGTC_1628 st004252 5.22 77.7 µM 6.58E-8 6 8.99E-8
7 SGTC_1681 tripelennamine 5.12 100.0 µM 1.14E-7 7 1.53E-7
8 SGTC_2427 5545055 5.10 42.8 µM 1.25E-7 3 1.68E-7
9 SGTC_1316 1272-0050 5.04 65.9 µM 1.73E-7 1 2.31E-7
10 SGTC_2434 5670830 5.01 169.9 µM 2.03E-7 9 2.71E-7
11 SGTC_789 1309-1135 4.45 70.6 µM 3.46E-6 ERG2 16 4.32E-6
12 SGTC_2917 7979103 4.35 53.8 µM 5.41E-6 20 6.70E-6
13 SGTC_422 cantharidin 4.33 155.0 µM 6.06E-6 cell wall signaling 45 7.48E-6
14 SGTC_3227 9130768 4.29 49.5 µM 7.41E-6 4 9.11E-6
15 SGTC_2243 6634756 4.25 200.0 µM 8.76E-6 17 1.07E-5
16 SGTC_598 3937-0236 4.18 20.2 µM 1.20E-5 ERG2 18 1.46E-5
17 SGTC_1437 4092-1038 4.14 11.6 µM 1.46E-5 15 1.77E-5
18 SGTC_2254 7938975 4.10 95.2 µM 1.69E-5 47 2.03E-5
19 SGTC_2757 clomiphene 4.09 4.2 µM 1.78E-5 fatty acid desaturase (OLE1) 35 2.14E-5
20 SGTC_1174 0739-0097 3.96 51.1 µM 3.18E-5 redox potentiating 33 3.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.97E-17 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.139 6.52E-16 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.129 6.65E-14 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.125 3.31E-13 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.122 1.41E-12 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.122 1.52E-12 YNL248C RPA49 hom RNA polymerase I subunit A49
0.122 1.53E-12 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.118 6.08E-12 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.118 6.88E-12 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.118 7.84E-12 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.117 9.18E-12 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.114 4.17E-11 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.113 5.82E-11 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.112 8.10E-11 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.112 9.11E-11 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A