YPR045C / THP3

Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR045C / THP3

Click on Significant Values for Screen Details ID:SGTC_438|Compound:sphingosine|FD-Score:5.00|P-value:8.06E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.24|P-value:3.95E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.67|P-value:1.99E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.57|P-value:1.63E-10 ID:SGTC_811|Compound:0416-0114|FD-Score:3.28|P-value:7.54E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.47|P-value:3.95E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.73|P-value:2.64E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.42|P-value:1.02E-7 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.44|P-value:9.80E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.55|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.68|P-value:1.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:5.41|P-value:1.07E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.85|P-value:1.04E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.52|P-value:3.38E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.95|P-value:7.18E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.00|P-value:5.86E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.39|P-value:5.22E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.40|P-value:1.12E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.22|P-value:9.30E-4 ID:SGTC_3156|Compound:9099931|FD-Score:4.45|P-value:9.17E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.42|P-value:4.69E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:5.00|P-value:8.06E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-4.24|P-value:3.95E-5 ID:SGTC_482|Compound:fipronil|FD-Score:3.67|P-value:1.99E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:6.57|P-value:1.63E-10 ID:SGTC_811|Compound:0416-0114|FD-Score:3.28|P-value:7.54E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.47|P-value:3.95E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.73|P-value:2.64E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.42|P-value:1.02E-7 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.44|P-value:9.80E-6 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.55|P-value:4.94E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.68|P-value:1.89E-4 ID:SGTC_1632|Compound:st005650|FD-Score:5.41|P-value:1.07E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.85|P-value:1.04E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.82|P-value:1.16E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.52|P-value:3.38E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.95|P-value:7.18E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.00|P-value:5.86E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.39|P-value:5.22E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.40|P-value:1.12E-7 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.83|P-value:1.11E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.22|P-value:9.30E-4 ID:SGTC_3156|Compound:9099931|FD-Score:4.45|P-value:9.17E-6 ID:SGTC_3290|Compound:9121031|FD-Score:3.42|P-value:4.69E-4

Top fitness defect scores for YPR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_804 1595-0054 6.57 20.9 µM 1.63E-10 sphingolipid biosynthesis & PDR1 8 2.55E-11
2 SGTC_1024 4507-0395 5.42 26.0 µM 1.02E-7 TSC3-RPN4 8 3.02E-8
3 SGTC_1632 st005650 5.41 90.0 µM 1.07E-7 5 3.20E-8
4 SGTC_2564 betulinic acid 5.40 100.0 µM 1.12E-7 10 3.35E-8
5 SGTC_438 sphingosine 5.00 6.7 µM 8.06E-7 10 2.93E-7
6 SGTC_3156 9099931 4.45 49.5 µM 9.17E-6 3 4.21E-6
7 SGTC_1448 4255-0083 4.44 152.0 µM 9.80E-6 ERG2 10 4.53E-6
8 SGTC_2100 5377183 4.00 190.0 µM 5.86E-5 60S ribosome export 10 3.20E-5
9 SGTC_2091 4-phenylthiadiazole 3.95 200.0 µM 7.18E-5 13 3.99E-5
10 SGTC_1785 bathophenanthroline 3.85 24.0 µM 1.04E-4 heme requiring 54 5.95E-5
11 SGTC_2774 tamoxifen 3.83 10.9 µM 1.11E-4 17 6.42E-5
12 SGTC_1920 st075728 3.82 45.7 µM 1.16E-4 24 6.71E-5
13 SGTC_1582 3',3',6'-trihydroxyflavone 3.68 74.0 µM 1.89E-4 11 1.15E-4
14 SGTC_482 fipronil 3.67 114.0 µM 1.99E-4 5 1.21E-4
15 SGTC_1512 0259-0544 3.54 12.2 µM 3.12E-4 30 1.98E-4
16 SGTC_1957 st077035 3.52 62.4 µM 3.38E-4 26 2.16E-4
17 SGTC_850 0388-0143 3.47 75.9 µM 3.95E-4 24 2.56E-4
18 SGTC_3290 9121031 3.42 71.4 µM 4.69E-4 26 3.08E-4
19 SGTC_2417 cerulenin 3.39 830.0 nM 5.22E-4 42 3.47E-4
20 SGTC_811 0416-0114 3.28 265.0 µM 7.54E-4 51 5.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.84E-17 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.128 9.34E-14 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.118 8.57E-12 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.112 7.30E-11 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.105 1.00E-9 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.103 1.89E-9 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.099 8.18E-9 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.089 2.53E-7 YBR180W DTR1 hom Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
0.086 5.83E-7 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.085 9.70E-7 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.083 1.47E-6 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.083 1.61E-6 YBL057C PTH2 hom One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
0.077 7.64E-6 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.077 7.84E-6 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.077 8.30E-6 YGR231C PHB2 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation