HIPHOP chemogenomics database
YPR046W / MCM16 
Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPR046W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 5.93E-10 | YNL170W_d | YNL170W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.084 | 9.65E-7 | YLR458W_d | YLR458W_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis |
| 0.082 | 2.23E-6 | YKL132C | RMA1 | hom | Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.080 | 3.21E-6 | YBR229C | ROT2 | hom | Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations |
| 0.080 | 3.39E-6 | YKR047W_d | YKR047W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 |
| 0.079 | 4.66E-6 | YHR039C | MSC7 | hom | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids |
| 0.074 | 2.00E-5 | YMR247W-A_p | YMR247W-A_p | hom | Putative protein of unknown function |
| 0.072 | 2.73E-5 | YKR069W | MET1 | hom | S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis |
| 0.072 | 3.29E-5 | YLR059C | REX2 | hom | 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease |
| 0.069 | 6.49E-5 | YOL099C_d | YOL099C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes |
| 0.069 | 6.91E-5 | YOR314W_d | YOR314W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.068 | 9.13E-5 | YNR055C | HOL1 | hom | Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake |
| 0.067 | 1.03E-4 | YPL216W_p | YPL216W_p | hom | Putative protein of unknown function; YPL216W is not an essential gene |
| 0.066 | 1.44E-4 | YPR045C | THP3 | hom | Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes |
| 0.065 | 1.64E-4 | YNL306W | MRPS18 | het | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins |