YPR046W / MCM16

Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR046W / MCM16

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.82|P-value:4.74E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.94|P-value:2.26E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.97|P-value:2.93E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.61|P-value:9.18E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:5.65|P-value:4.56E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.61|P-value:3.20E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.89|P-value:1.09E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.83|P-value:3.31E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.17|P-value:1.54E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.83|P-value:4.57E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.58|P-value:9.84E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.53|P-value:8.23E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.95|P-value:3.17E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.93|P-value:3.35E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.80|P-value:1.01E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:7.30|P-value:1.01E-10 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.74|P-value:4.37E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:5.76|P-value:2.74E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.65|P-value:7.98E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.31|P-value:2.02E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.15|P-value:1.63E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:6.30|P-value:2.17E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.17|P-value:1.05E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.88|P-value:3.93E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.28|P-value:1.05E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.01|P-value:2.62E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.22|P-value:1.30E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.62|P-value:8.93E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.82|P-value:4.84E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.63|P-value:3.03E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.79|P-value:5.16E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.56|P-value:7.52E-4 ID:SGTC_2365|Compound:9042475|FD-Score:7.68|P-value:1.12E-11 ID:SGTC_2403|Compound:6032726|FD-Score:4.10|P-value:1.96E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.21|P-value:3.09E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.65|P-value:8.10E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:6.45|P-value:9.90E-9 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.37|P-value:1.57E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.62|P-value:8.70E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.02|P-value:2.54E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.56|P-value:7.53E-4 ID:SGTC_3095|Compound:9117207|FD-Score:-4.97|P-value:5.30E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.61|P-value:9.06E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.99|P-value:2.79E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.92|P-value:3.44E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.83|P-value:4.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.20|P-value:1.40E-4 ID:SGTC_3298|Compound:9116858|FD-Score:5.65|P-value:4.62E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.82|P-value:4.74E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.94|P-value:2.26E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.97|P-value:2.93E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.61|P-value:9.18E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:5.65|P-value:4.56E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.61|P-value:3.20E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.89|P-value:1.09E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.83|P-value:3.31E-4 ID:SGTC_484|Compound:loperamide|FD-Score:4.17|P-value:1.54E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.83|P-value:4.57E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.58|P-value:9.84E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.53|P-value:8.23E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.95|P-value:3.17E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.93|P-value:3.35E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-4.80|P-value:1.01E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:7.30|P-value:1.01E-10 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.74|P-value:4.37E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:5.76|P-value:2.74E-7 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.65|P-value:7.98E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.31|P-value:2.02E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.15|P-value:1.63E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:6.30|P-value:2.17E-8 ID:SGTC_1142|Compound:3253-1408|FD-Score:-4.17|P-value:1.05E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.88|P-value:3.93E-4 ID:SGTC_1761|Compound:st044296|FD-Score:4.28|P-value:1.05E-4 ID:SGTC_1807|Compound:st050092|FD-Score:4.01|P-value:2.62E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.22|P-value:1.30E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.62|P-value:8.93E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.82|P-value:4.84E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.63|P-value:3.03E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.79|P-value:5.16E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.56|P-value:7.52E-4 ID:SGTC_2365|Compound:9042475|FD-Score:7.68|P-value:1.12E-11 ID:SGTC_2403|Compound:6032726|FD-Score:4.10|P-value:1.96E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:5.21|P-value:3.09E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.65|P-value:8.10E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:6.45|P-value:9.90E-9 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.37|P-value:1.57E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.62|P-value:8.70E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.02|P-value:2.54E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.56|P-value:7.53E-4 ID:SGTC_3095|Compound:9117207|FD-Score:-4.97|P-value:5.30E-6 ID:SGTC_3112|Compound:9123419|FD-Score:3.61|P-value:9.06E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.99|P-value:2.79E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.92|P-value:3.44E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.83|P-value:4.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.20|P-value:1.40E-4 ID:SGTC_3298|Compound:9116858|FD-Score:5.65|P-value:4.62E-7

Top fitness defect scores for YPR046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2365 9042475 7.68 200.0 µM 1.12E-11 4 8.03E-15
2 SGTC_804 1595-0054 7.30 20.9 µM 1.01E-10 sphingolipid biosynthesis & PDR1 7 1.40E-13
3 SGTC_2562 3',7'-dimethoxyflavone 6.45 64.9 µM 9.90E-9 2 5.48E-11
4 SGTC_1135 dihydrocapsaicin 6.30 536.7 nM 2.17E-8 5 1.52E-10
5 SGTC_931 2812-0076 5.76 566.0 µM 2.74E-7 2 4.11E-9
6 SGTC_160 3453-0671 5.65 289.7 µM 4.56E-7 11 7.98E-9
7 SGTC_3298 9116858 5.65 71.4 µM 4.62E-7 3 8.14E-9
8 SGTC_2633 5,7-dihydroxyisoflavone 5.37 100.0 µM 1.57E-6 12 3.98E-8
9 SGTC_1017 4239-0030 5.31 168.0 µM 2.02E-6 6 5.53E-8
10 SGTC_2495 cafestol 5.21 54.5 µM 3.09E-6 Golgi 11 9.63E-8
11 SGTC_479 n-linoleoylglycine 4.89 10.0 µM 1.09E-5 5 4.94E-7
12 SGTC_2040 5100729 4.63 123.0 µM 3.03E-5 28 1.87E-6
13 SGTC_165 k038-0023 4.61 64.4 µM 3.20E-5 ubiquinone biosynthesis & proteasome 57 2.01E-6
14 SGTC_1761 st044296 4.28 37.0 µM 1.05E-4 9 9.31E-6
15 SGTC_1934 st074720 4.22 32.6 µM 1.30E-4 43 1.23E-5
16 SGTC_3278 9139605 4.20 49.5 µM 1.40E-4 8 1.36E-5
17 SGTC_484 loperamide 4.17 105.0 µM 1.54E-4 2 1.54E-5
18 SGTC_1030 k029-0042 4.15 36.7 µM 1.63E-4 TSC3-RPN4 21 1.66E-5
19 SGTC_2403 6032726 4.10 181.2 µM 1.96E-4 38 2.11E-5
20 SGTC_2950 9072895 4.02 21.5 µM 2.54E-4 33 2.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.93E-10 YNL170W_d YNL170W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 9.65E-7 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.082 2.23E-6 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.080 3.21E-6 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.080 3.39E-6 YKR047W_d YKR047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
0.079 4.66E-6 YHR039C MSC7 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
0.074 2.00E-5 YMR247W-A_p YMR247W-A_p hom Putative protein of unknown function
0.072 2.73E-5 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.072 3.29E-5 YLR059C REX2 hom 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
0.069 6.49E-5 YOL099C_d YOL099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
0.069 6.91E-5 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.068 9.13E-5 YNR055C HOL1 hom Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake
0.067 1.03E-4 YPL216W_p YPL216W_p hom Putative protein of unknown function; YPL216W is not an essential gene
0.066 1.44E-4 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.065 1.64E-4 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins