YPR047W / MSF1

Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR047W / MSF1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.46|P-value:1.38E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:3.58|P-value:4.11E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.79|P-value:2.43E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.98|P-value:9.58E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.51|P-value:5.19E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.37|P-value:8.20E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:5.73E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:2.24E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:4.62|P-value:7.33E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:6.45|P-value:6.03E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.00|P-value:8.08E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.99|P-value:9.45E-5 ID:SGTC_442|Compound:cape|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.02|P-value:6.69E-15 ID:SGTC_456|Compound:gingerol|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.18|P-value:4.51E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:3.48|P-value:5.67E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.49|P-value:5.48E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.74|P-value:4.25E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.58|P-value:8.56E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.50|P-value:5.27E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.54|P-value:4.68E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:9.87E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.66|P-value:3.04E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.57|P-value:4.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.19|P-value:9.63E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:4.84E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.18|P-value:4.46E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:7.39|P-value:1.50E-12 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.37|P-value:8.23E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.97|P-value:9.85E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.87|P-value:1.43E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.05|P-value:7.41E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.59|P-value:3.94E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.49|P-value:5.48E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.19|P-value:4.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:7.41E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.68|P-value:2.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.07|P-value:6.71E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.34|P-value:8.95E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-4.31|P-value:1.50E-5 ID:SGTC_2526|Compound:patulin|FD-Score:6.02|P-value:6.91E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.91|P-value:1.26E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:6.16|P-value:3.16E-9 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.42|P-value:7.10E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.40|P-value:7.58E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.13|P-value:5.39E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.38|P-value:7.86E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:5.80E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.53|P-value:4.88E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.46|P-value:3.96E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.46|P-value:1.38E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:3.58|P-value:4.11E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.79|P-value:2.43E-8 ID:SGTC_68|Compound:0986-0284|FD-Score:3.45|P-value:6.41E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.98|P-value:9.58E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.51|P-value:5.19E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.37|P-value:8.20E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.98|P-value:5.73E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:2.24E-6 ID:SGTC_211|Compound:3455-0679|FD-Score:4.62|P-value:7.33E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:6.45|P-value:6.03E-10 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.00|P-value:8.08E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.99|P-value:9.45E-5 ID:SGTC_442|Compound:cape|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.02|P-value:6.69E-15 ID:SGTC_456|Compound:gingerol|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.18|P-value:4.51E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:3.48|P-value:5.67E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.92|P-value:1.23E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.49|P-value:5.48E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.74|P-value:4.25E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.58|P-value:8.56E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.50|P-value:5.27E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.54|P-value:4.68E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.97|P-value:9.87E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.66|P-value:3.04E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.57|P-value:4.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.19|P-value:9.63E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.53|P-value:4.84E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.18|P-value:4.46E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:7.39|P-value:1.50E-12 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.37|P-value:8.23E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.97|P-value:9.85E-5 ID:SGTC_1526|Compound:st051518|FD-Score:3.87|P-value:1.43E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.05|P-value:7.41E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.59|P-value:3.94E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.49|P-value:5.48E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.19|P-value:4.23E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.05|P-value:7.41E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.68|P-value:2.84E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.07|P-value:6.71E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.34|P-value:8.95E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_2469|Compound:5655019|FD-Score:-4.31|P-value:1.50E-5 ID:SGTC_2526|Compound:patulin|FD-Score:6.02|P-value:6.91E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.91|P-value:1.26E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:6.16|P-value:3.16E-9 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.42|P-value:7.10E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.40|P-value:7.58E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_2793|Compound:7325131|FD-Score:4.13|P-value:5.39E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.38|P-value:7.86E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:5.80E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.53|P-value:4.88E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-3.46|P-value:3.96E-4

Top fitness defect scores for YPR047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1160 4092-0570 7.39 10.5 µM 1.50E-12 plasma membrane duress 8 7.28E-14
2 SGTC_236 1509-0011 6.45 5.3 µM 6.03E-10 279 5.67E-11
3 SGTC_2557 derrustone 6.16 83.8 µM 3.16E-9 5 3.56E-10
4 SGTC_2526 patulin 6.02 37.6 µM 6.91E-9 27 8.50E-10
5 SGTC_275 trichlorophene 6.00 5.7 µM 8.08E-9 mitochondrial stress 120 1.01E-9
6 SGTC_63 0099-0242 5.79 26.7 µM 2.43E-8 mitochondrial stress 30 3.44E-9
7 SGTC_10 0279-0212 5.46 42.6 µM 1.38E-7 TRP & mitochondrial translation 40 2.37E-8
8 SGTC_442 cape 5.05 100.0 µM 1.03E-6 2 2.21E-7
9 SGTC_173 1273-0061 4.88 2.7 µM 2.24E-6 mitochondrial stress 153 5.24E-7
10 SGTC_676 falcarinol 4.74 140.0 µM 4.25E-6 38 1.07E-6
11 SGTC_211 3455-0679 4.62 143.5 µM 7.33E-6 9 1.96E-6
12 SGTC_908 3448-7491 4.58 47.7 µM 8.56E-6 mitochondrial stress 92 2.33E-6
13 SGTC_456 gingerol 4.27 170.0 µM 3.12E-5 13 9.81E-6
14 SGTC_2232 chlorophetanol 4.19 41.5 µM 4.23E-5 TRP & mitochondrial translation 111 1.38E-5
15 SGTC_1154 4088-0362 4.18 150.0 µM 4.46E-5 17 1.46E-5
16 SGTC_467 ro 31-8220 4.18 72.8 µM 4.51E-5 calcium & mitochondrial duress 66 1.48E-5
17 SGTC_141 0443-0274 4.17 32.3 µM 4.70E-5 mitochondrial response to ROS 38 1.55E-5
18 SGTC_2793 7325131 4.13 81.8 µM 5.39E-5 14 1.80E-5
19 SGTC_2361 9034121 4.07 116.0 µM 6.71E-5 RSC complex & mRNA processing 17 2.30E-5
20 SGTC_2250 alverine citrate 4.05 130.0 µM 7.41E-5 146 2.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.325 2.44E-83 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.319 2.25E-80 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.318 6.29E-80 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.308 2.04E-74 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.303 3.69E-72 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.301 2.29E-71 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.299 3.18E-70 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.298 1.07E-69 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.297 1.52E-69 YBL090W MRP21 hom Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
0.295 1.54E-68 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.295 2.01E-68 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.293 1.16E-67 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.293 1.17E-67 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.288 4.73E-65 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.288 5.98E-65 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth