YPR048W / TAH18

Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR048W / TAH18

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-5.67|P-value:7.91E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.53|P-value:1.95E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.91|P-value:9.62E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.66|P-value:5.02E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.85|P-value:2.14E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.92|P-value:9.67E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.15|P-value:3.97E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.12|P-value:4.56E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.94|P-value:8.67E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.07|P-value:5.41E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.07|P-value:5.40E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.07|P-value:7.32E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-2.91|P-value:9.60E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.42|P-value:1.36E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.76|P-value:3.18E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.47|P-value:3.02E-12 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.52|P-value:8.78E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.01|P-value:6.79E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.51|P-value:9.29E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.30|P-value:2.37E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.08|P-value:5.21E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.56|P-value:6.01E-7 ID:SGTC_1885|Compound:st057546|FD-Score:-4.02|P-value:9.13E-6 ID:SGTC_1897|Compound:st060201|FD-Score:-3.72|P-value:3.80E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.30|P-value:2.24E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.93|P-value:9.27E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-2.94|P-value:8.85E-4 ID:SGTC_2080|Compound:5212524|FD-Score:5.10|P-value:2.96E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.31|P-value:2.09E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.61|P-value:6.06E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.04|P-value:6.21E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.87|P-value:1.10E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.02|P-value:6.65E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.57|P-value:7.05E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.03|P-value:6.20E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.53|P-value:8.57E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.14|P-value:4.14E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.54|P-value:8.30E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.18|P-value:3.60E-4 ID:SGTC_2992|Compound:9074591|FD-Score:2.94|P-value:8.98E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.09|P-value:4.92E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.81|P-value:2.58E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.67|P-value:7.91E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.53|P-value:1.95E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.91|P-value:9.62E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.66|P-value:5.02E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.85|P-value:2.14E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:3.49|P-value:1.03E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:2.92|P-value:9.67E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.15|P-value:3.97E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.12|P-value:4.56E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.94|P-value:8.67E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.07|P-value:5.41E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.07|P-value:5.40E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.24|P-value:2.81E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.07|P-value:7.32E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-2.91|P-value:9.60E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.42|P-value:1.36E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.76|P-value:3.18E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:6.47|P-value:3.02E-12 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.52|P-value:8.78E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.01|P-value:6.79E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.51|P-value:9.29E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.30|P-value:2.37E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.08|P-value:5.21E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.56|P-value:6.01E-7 ID:SGTC_1885|Compound:st057546|FD-Score:-4.02|P-value:9.13E-6 ID:SGTC_1897|Compound:st060201|FD-Score:-3.72|P-value:3.80E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.30|P-value:2.24E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_1976|Compound:st070609|FD-Score:2.93|P-value:9.27E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-2.94|P-value:8.85E-4 ID:SGTC_2080|Compound:5212524|FD-Score:5.10|P-value:2.96E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.31|P-value:2.09E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.61|P-value:6.06E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.04|P-value:6.21E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.87|P-value:1.10E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.02|P-value:6.65E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.16|P-value:3.91E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.57|P-value:7.05E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.03|P-value:6.20E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.53|P-value:8.57E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.14|P-value:4.14E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.54|P-value:8.30E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.18|P-value:3.60E-4 ID:SGTC_2992|Compound:9074591|FD-Score:2.94|P-value:8.98E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.09|P-value:4.92E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.81|P-value:2.58E-5

Top fitness defect scores for YPR048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1212 0520-0165 6.47 585.0 µM 3.02E-12 1 5.06E-11 1.65
2 SGTC_45 0kpi-0036 5.53 14.9 µM 1.95E-9 excess fatty acid 2 1.56E-8 0.29
3 SGTC_2080 5212524 5.10 12.4 µM 2.96E-8 copper-dependent oxidative stress 2 1.74E-7 0.08
4 SGTC_2436 5633522 4.87 8.1 µM 1.10E-7 6 5.58E-7 0.10
5 SGTC_1467 k284-1082 4.30 293.0 µM 2.37E-6 3 8.48E-6 0.58
6 SGTC_758 0868-0029 4.07 16.0 µM 7.32E-6 3 2.31E-5 1.04
7 SGTC_246 cycloheximide 3.85 667.0 µM 2.14E-5 11 5.98E-5 0.06
8 SGTC_3234 9132280 3.81 49.5 µM 2.58E-5 6 7.06E-5 0.30
9 SGTC_1134 3477-0009 3.76 42.5 µM 3.18E-5 16 8.51E-5 0.02
10 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.66 300.0 µM 5.02E-5 heat shock/prefoldin 3 1.28E-4 0.19
11 SGTC_2876 9059903 3.54 26.0 µM 8.30E-5 2 2.00E-4 0.24
12 SGTC_2772 vinpocetine 3.53 57.1 µM 8.57E-5 9 2.06E-4 0.18
13 SGTC_1377 2944-0135 3.51 198.0 µM 9.29E-5 calcium & mitochondrial duress 11 2.21E-4 0.10
14 SGTC_282 k297-0036 3.49 65.7 µM 1.03E-4 6 2.42E-4 0.14
15 SGTC_1060 3448-7350 3.42 82.0 µM 1.36E-4 Golgi 18 3.10E-4 0.01
16 SGTC_2313 7726885 3.31 200.0 µM 2.18E-4 RPP1 & pyrimidine depletion 13 4.71E-4 0.05
17 SGTC_1940 st075990 3.30 51.1 µM 2.24E-4 60S ribosome export 8 4.83E-4 0.08
18 SGTC_686 1319-0111 3.24 510.0 µM 2.81E-4 60S ribosome export 16 5.91E-4 0.03
19 SGTC_1969 st069479 3.24 40.1 µM 2.87E-4 6 6.03E-4 0.00
20 SGTC_2035 5154463 3.19 94.6 µM 3.45E-4 18 7.11E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.58E-10 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication
0.108 3.20E-10 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.108 3.71E-10 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.103 2.04E-9 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.103 2.29E-9 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.103 2.46E-9 YJR068W RFC2 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.097 1.74E-8 YER085C_p YER085C_p hom Putative protein of unknown function
0.097 2.11E-8 YKR050W TRK2 hom Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
0.092 1.09E-7 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.091 1.12E-7 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.091 1.52E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.84E-7 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.086 6.42E-7 YIL023C YKE4 hom Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
0.085 7.28E-7 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
0.083 1.66E-6 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component