YPR049C / ATG11

Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR049C / ATG11

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.29|P-value:2.74E-15 ID:SGTC_145|Compound:3737-0113|FD-Score:4.49|P-value:1.15E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.45|P-value:5.80E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.64|P-value:3.00E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:5.38|P-value:1.95E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.56|P-value:3.91E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.60|P-value:3.42E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.31|P-value:9.19E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.99|P-value:8.52E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.38|P-value:7.19E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.54|P-value:4.19E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.28|P-value:9.94E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.93|P-value:3.81E-14 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.18|P-value:2.68E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.38|P-value:1.86E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.07|P-value:6.22E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.32|P-value:8.76E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.45|P-value:1.36E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.66|P-value:2.76E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.07|P-value:6.21E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:1.74E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.92|P-value:1.09E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.22|P-value:3.43E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.59|P-value:6.71E-8 ID:SGTC_2007|Compound:4011539|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.83|P-value:2.69E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2221|Compound:6807166|FD-Score:-3.68|P-value:2.53E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.99|P-value:8.35E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.53|P-value:9.44E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.57|P-value:3.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.82|P-value:1.61E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.69|P-value:2.45E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.77|P-value:3.42E-6 ID:SGTC_2848|Compound:9016370|FD-Score:3.31|P-value:8.97E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.36|P-value:7.81E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.54|P-value:4.15E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.48|P-value:1.21E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.92|P-value:1.11E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.85|P-value:2.39E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.59|P-value:3.48E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-4.22|P-value:3.38E-5 ID:SGTC_3280|Compound:9140961|FD-Score:6.71|P-value:1.26E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:8.29|P-value:2.74E-15 ID:SGTC_145|Compound:3737-0113|FD-Score:4.49|P-value:1.15E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.45|P-value:5.80E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.64|P-value:3.00E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:5.38|P-value:1.95E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.56|P-value:3.91E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.60|P-value:3.42E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.46|P-value:1.25E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.31|P-value:9.19E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.81|P-value:1.67E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.99|P-value:8.52E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.38|P-value:7.19E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.54|P-value:4.19E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.28|P-value:9.94E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.93|P-value:3.81E-14 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.18|P-value:2.68E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.80|P-value:1.71E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.38|P-value:1.86E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.07|P-value:6.22E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.32|P-value:8.76E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.45|P-value:1.36E-5 ID:SGTC_1709|Compound:st033179|FD-Score:3.66|P-value:2.76E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.07|P-value:6.21E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:1.74E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.83|P-value:1.52E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.92|P-value:1.09E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.22|P-value:3.43E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.59|P-value:6.71E-8 ID:SGTC_2007|Compound:4011539|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.83|P-value:2.69E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2221|Compound:6807166|FD-Score:-3.68|P-value:2.53E-4 ID:SGTC_2225|Compound:6654152|FD-Score:-3.99|P-value:8.35E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.53|P-value:9.44E-6 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.57|P-value:3.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.82|P-value:1.61E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.69|P-value:2.45E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.77|P-value:3.42E-6 ID:SGTC_2848|Compound:9016370|FD-Score:3.31|P-value:8.97E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.36|P-value:7.81E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.54|P-value:4.15E-4 ID:SGTC_3009|Compound:9080819|FD-Score:4.48|P-value:1.21E-5 ID:SGTC_3057|Compound:9095946|FD-Score:3.92|P-value:1.11E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-4.85|P-value:2.39E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.59|P-value:3.48E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-4.22|P-value:3.38E-5 ID:SGTC_3280|Compound:9140961|FD-Score:6.71|P-value:1.26E-10

Top fitness defect scores for YPR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.29 9.0 µM 2.74E-15 cell wall 113 5.72E-17
2 SGTC_1123 mangostin 7.93 811.3 nM 3.81E-14 mitochondrial response to ROS 4 1.10E-15
3 SGTC_3280 9140961 6.71 49.5 µM 1.26E-10 60S ribosome export 2 9.75E-12
4 SGTC_1953 st076800 5.59 12.1 µM 6.71E-8 17 1.11E-8
5 SGTC_573 3702-0553 5.38 84.7 µM 1.95E-7 1 3.68E-8
6 SGTC_2165 5727197 4.83 32.1 µM 2.69E-6 20 6.96E-7
7 SGTC_2833 9001315 4.77 45.5 µM 3.42E-6 amide catabolism 33 9.10E-7
8 SGTC_145 3737-0113 4.49 38.4 µM 1.15E-5 DNA intercalators 57 3.55E-6
9 SGTC_3009 9080819 4.48 71.4 µM 1.21E-5 9 3.73E-6
10 SGTC_1611 st001856 4.45 99.4 µM 1.36E-5 8 4.27E-6
11 SGTC_1385 3091-4834 4.38 14.1 µM 1.86E-5 RPP1 & pyrimidine depletion 12 6.05E-6
12 SGTC_1714 st033236 4.07 13.6 µM 6.21E-5 18 2.33E-5
13 SGTC_1410 3909-8106 4.07 77.9 µM 6.22E-5 9 2.34E-5
14 SGTC_924 2046-0044 3.99 21.3 µM 8.52E-5 15 3.33E-5
15 SGTC_1887 st057648 3.92 70.8 µM 1.09E-4 16 4.36E-5
16 SGTC_3062 9077494 3.92 49.5 µM 1.10E-4 mitochondrial response to ROS 38 4.41E-5
17 SGTC_3057 9095946 3.92 49.5 µM 1.11E-4 Golgi 15 4.48E-5
18 SGTC_1550 gossypolone 3.91 36.6 µM 1.15E-4 13 4.63E-5
19 SGTC_1865 st057639 3.83 52.2 µM 1.52E-4 13 6.34E-5
20 SGTC_2614 arthonioic acid 3.82 13.4 µM 1.61E-4 24 6.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.36E-23 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.155 1.47E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.146 1.95E-17 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.144 4.95E-17 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.143 8.21E-17 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.138 1.13E-15 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.136 2.25E-15 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.136 2.43E-15 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.132 1.75E-14 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.129 5.33E-14 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.129 5.61E-14 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.127 1.53E-13 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.124 6.09E-13 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.122 1.22E-12 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.120 3.49E-12 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance