YPR050C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR050C / YPR050C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.61|P-value:9.05E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.00|P-value:2.67E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.63|P-value:5.37E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.86|P-value:4.27E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:12.50|P-value:6.60E-28 ID:SGTC_146|Compound:3448-8650|FD-Score:3.87|P-value:4.13E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.14|P-value:1.73E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.96|P-value:2.69E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:9.63|P-value:3.34E-17 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.34|P-value:1.59E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.87|P-value:4.07E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:11.50|P-value:1.40E-23 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.79|P-value:4.69E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.98|P-value:2.59E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.96|P-value:2.75E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:5.29|P-value:2.35E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:7.01|P-value:6.01E-10 ID:SGTC_581|Compound:0958-0271|FD-Score:4.33|P-value:8.98E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:4.30|P-value:1.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.95|P-value:3.16E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.20|P-value:3.32E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:4.01|P-value:2.57E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.13|P-value:1.79E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.58|P-value:8.78E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.92|P-value:3.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.75|P-value:5.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.77|P-value:5.53E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.29|P-value:1.02E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.96|P-value:3.08E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.80|P-value:5.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.66|P-value:6.97E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.52|P-value:4.58E-5 ID:SGTC_2079|Compound:5212404|FD-Score:4.06|P-value:2.19E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.74|P-value:2.02E-5 ID:SGTC_2153|Compound:5569715|FD-Score:5.26|P-value:2.67E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.21|P-value:1.33E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.68|P-value:7.25E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.07|P-value:2.14E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.58|P-value:9.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.32|P-value:2.71E-13 ID:SGTC_3005|Compound:9076496|FD-Score:4.15|P-value:1.63E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.85|P-value:1.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.95|P-value:2.80E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.58|P-value:3.71E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.61|P-value:9.05E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.00|P-value:2.67E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.63|P-value:5.37E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.86|P-value:4.27E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:12.50|P-value:6.60E-28 ID:SGTC_146|Compound:3448-8650|FD-Score:3.87|P-value:4.13E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.14|P-value:1.73E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.96|P-value:2.69E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:9.63|P-value:3.34E-17 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.34|P-value:1.59E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.87|P-value:4.07E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:11.50|P-value:1.40E-23 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.79|P-value:4.69E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.98|P-value:2.59E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.96|P-value:2.75E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:5.29|P-value:2.35E-6 ID:SGTC_574|Compound:1315-0397|FD-Score:7.01|P-value:6.01E-10 ID:SGTC_581|Compound:0958-0271|FD-Score:4.33|P-value:8.98E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:4.30|P-value:1.00E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.95|P-value:3.16E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.20|P-value:3.32E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:4.01|P-value:2.57E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.13|P-value:1.79E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.58|P-value:8.78E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.92|P-value:3.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.75|P-value:5.93E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.77|P-value:5.53E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.29|P-value:1.02E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.96|P-value:3.08E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.80|P-value:5.14E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.66|P-value:6.97E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.52|P-value:4.58E-5 ID:SGTC_2079|Compound:5212404|FD-Score:4.06|P-value:2.19E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.74|P-value:2.02E-5 ID:SGTC_2153|Compound:5569715|FD-Score:5.26|P-value:2.67E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.21|P-value:1.33E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.68|P-value:7.25E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.07|P-value:2.14E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.58|P-value:9.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.32|P-value:2.71E-13 ID:SGTC_3005|Compound:9076496|FD-Score:4.15|P-value:1.63E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.85|P-value:1.33E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.95|P-value:2.80E-4 ID:SGTC_3335|Compound:9143315|FD-Score:4.58|P-value:3.71E-5

Top fitness defect scores for YPR050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_124 0136-0217 12.50 7.1 µM 6.60E-28 mitochondrial stress 5 2.10E-36
2 SGTC_528 3492-0019 11.50 172.0 µM 1.40E-23 calcium & mitochondrial duress 33 1.11E-30
3 SGTC_430 0958-0115 9.63 16.4 µM 3.34E-17 2 3.02E-22
4 SGTC_2752 diclazuril 8.32 33.1 µM 2.71E-13 31 4.42E-17
5 SGTC_574 1315-0397 7.01 40.0 µM 6.01E-10 2 1.15E-12
6 SGTC_119 0121-0043 5.63 24.8 µM 5.37E-7 mitochondrial stress 31 8.97E-9
7 SGTC_572 0960-0087 5.29 17.7 µM 2.35E-6 5 6.25E-8
8 SGTC_2153 5569715 5.26 200.0 µM 2.67E-6 iron homeostasis 9 7.40E-8
9 SGTC_937 3122-0005 5.20 46.7 µM 3.32E-6 13 9.85E-8
10 SGTC_3013 9080133 4.85 71.4 µM 1.33E-5 6 6.13E-7
11 SGTC_2110 5483698 4.74 200.0 µM 2.02E-5 TSC3-RPN4 13 1.05E-6
12 SGTC_3335 9143315 4.58 29.6 µM 3.71E-5 fatty acid desaturase (OLE1) 6 2.35E-6
13 SGTC_1947 st076332 4.52 61.6 µM 4.58E-5 10 3.09E-6
14 SGTC_581 0958-0271 4.33 211.0 µM 8.98E-5 41 7.49E-6
15 SGTC_681 1642-0006 4.30 26.6 µM 1.00E-4 2 8.65E-6
16 SGTC_1632 st005650 4.29 90.0 µM 1.02E-4 19 8.88E-6
17 SGTC_2379 9035213 4.21 200.0 µM 1.33E-4 15 1.25E-5
18 SGTC_3005 9076496 4.15 71.4 µM 1.63E-4 5 1.63E-5
19 SGTC_240 5hr heat shock (37°C) + Streptovitacin 4.14 300.0 µM 1.73E-4 heat shock/prefoldin 32 1.77E-5
20 SGTC_999 4022-0066 4.13 22.7 µM 1.79E-4 Golgi 35 1.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.273 2.39E-58 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.260 5.80E-53 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.231 6.62E-42 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.210 1.14E-34 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.206 1.71E-33 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.170 2.73E-23 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.169 4.99E-23 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.157 7.11E-20 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.157 7.59E-20 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
0.155 1.93E-19 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.154 3.62E-19 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.153 3.94E-19 YPR051W MAK3 hom Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
0.145 3.67E-17 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.141 2.09E-16 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 2.78E-16 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability