YPR051W / MAK3

Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR051W / MAK3

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.83|P-value:4.40E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.50|P-value:4.63E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.92|P-value:3.31E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:8.34|P-value:1.82E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:6.06|P-value:6.66E-8 ID:SGTC_269|Compound:exalamide|FD-Score:5.24|P-value:2.65E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.01|P-value:2.52E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:6.58|P-value:5.25E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:4.48|P-value:4.97E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:5.29|P-value:2.15E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-8.27|P-value:2.01E-13 ID:SGTC_435|Compound:c-PAF|FD-Score:-16.90|P-value:1.04E-49 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.14|P-value:1.62E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.81|P-value:4.77E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.43|P-value:4.91E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.90|P-value:3.61E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.07|P-value:5.21E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:4.95|P-value:8.43E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.96|P-value:2.97E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.57|P-value:9.87E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.81|P-value:4.68E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.07|P-value:2.09E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.38|P-value:7.11E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.17|P-value:1.47E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.89|P-value:1.48E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:4.05|P-value:2.21E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.33|P-value:1.81E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.95|P-value:3.07E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.74|P-value:5.90E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.24|P-value:1.18E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.97|P-value:2.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:7.19|P-value:1.95E-10 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.35|P-value:7.89E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.64|P-value:7.97E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.88|P-value:3.78E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.30|P-value:9.42E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.36|P-value:1.57E-8 ID:SGTC_1784|Compound:st039334|FD-Score:-4.03|P-value:1.98E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.20|P-value:3.05E-6 ID:SGTC_1812|Compound:st052057|FD-Score:5.62|P-value:5.20E-7 ID:SGTC_1868|Compound:st057644|FD-Score:5.76|P-value:2.76E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.73|P-value:5.18E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.07|P-value:2.04E-4 ID:SGTC_2040|Compound:5100729|FD-Score:6.27|P-value:2.49E-8 ID:SGTC_2070|Compound:5230947|FD-Score:4.05|P-value:2.21E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.95|P-value:2.55E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.04|P-value:2.26E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.20|P-value:1.33E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.52|P-value:4.35E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.43|P-value:5.97E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.00|P-value:2.62E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.60|P-value:8.94E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.68|P-value:7.08E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.10|P-value:1.87E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.60|P-value:9.10E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.64|P-value:6.80E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.80|P-value:4.15E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.83|P-value:1.39E-9 ID:SGTC_2941|Compound:9056145|FD-Score:4.98|P-value:7.61E-6 ID:SGTC_2983|Compound:9022671|FD-Score:-5.45|P-value:8.44E-7 ID:SGTC_3255|Compound:9139072|FD-Score:3.62|P-value:8.48E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.59|P-value:3.29E-5 ID:SGTC_3344|Compound:9148862|FD-Score:7.19|P-value:1.92E-10 ID:SGTC_56|Compound:0957-0365|FD-Score:3.83|P-value:4.40E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.50|P-value:4.63E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.92|P-value:3.31E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:8.34|P-value:1.82E-13 ID:SGTC_146|Compound:3448-8650|FD-Score:6.06|P-value:6.66E-8 ID:SGTC_269|Compound:exalamide|FD-Score:5.24|P-value:2.65E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.01|P-value:2.52E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:6.58|P-value:5.25E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:4.48|P-value:4.97E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:5.29|P-value:2.15E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-8.27|P-value:2.01E-13 ID:SGTC_435|Compound:c-PAF|FD-Score:-16.90|P-value:1.04E-49 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.14|P-value:1.62E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.81|P-value:4.77E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.43|P-value:4.91E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.90|P-value:3.61E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.07|P-value:5.21E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:4.95|P-value:8.43E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.96|P-value:2.97E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.57|P-value:9.87E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.81|P-value:4.68E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.07|P-value:2.09E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.38|P-value:7.11E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.17|P-value:1.47E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.89|P-value:1.48E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:4.05|P-value:2.21E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.33|P-value:1.81E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.95|P-value:3.07E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.74|P-value:5.90E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.24|P-value:1.18E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.97|P-value:2.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:7.19|P-value:1.95E-10 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.35|P-value:7.89E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.64|P-value:7.97E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.88|P-value:3.78E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.30|P-value:9.42E-5 ID:SGTC_1687|Compound:st020778|FD-Score:6.36|P-value:1.57E-8 ID:SGTC_1784|Compound:st039334|FD-Score:-4.03|P-value:1.98E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.20|P-value:3.05E-6 ID:SGTC_1812|Compound:st052057|FD-Score:5.62|P-value:5.20E-7 ID:SGTC_1868|Compound:st057644|FD-Score:5.76|P-value:2.76E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.73|P-value:5.18E-4 ID:SGTC_2003|Compound:4023581|FD-Score:4.07|P-value:2.04E-4 ID:SGTC_2040|Compound:5100729|FD-Score:6.27|P-value:2.49E-8 ID:SGTC_2070|Compound:5230947|FD-Score:4.05|P-value:2.21E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.95|P-value:2.55E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.04|P-value:2.26E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.20|P-value:1.33E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.52|P-value:4.35E-5 ID:SGTC_2403|Compound:6032726|FD-Score:4.43|P-value:5.97E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.00|P-value:2.62E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.60|P-value:8.94E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.68|P-value:7.08E-4 ID:SGTC_2713|Compound:st079149|FD-Score:4.10|P-value:1.87E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.60|P-value:9.10E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.64|P-value:6.80E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-3.80|P-value:4.15E-4 ID:SGTC_2845|Compound:9003024|FD-Score:6.83|P-value:1.39E-9 ID:SGTC_2941|Compound:9056145|FD-Score:4.98|P-value:7.61E-6 ID:SGTC_2983|Compound:9022671|FD-Score:-5.45|P-value:8.44E-7 ID:SGTC_3255|Compound:9139072|FD-Score:3.62|P-value:8.48E-4 ID:SGTC_3338|Compound:9144300|FD-Score:4.59|P-value:3.29E-5 ID:SGTC_3344|Compound:9148862|FD-Score:7.19|P-value:1.92E-10

Top fitness defect scores for YPR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_124 0136-0217 8.34 7.1 µM 1.82E-13 mitochondrial stress 9 3.58E-17
2 SGTC_3344 9148862 7.19 3.9 µM 1.92E-10 1 3.21E-13
3 SGTC_1124 fisetin 7.19 1.2 µM 1.95E-10 3 3.29E-13
4 SGTC_2845 9003024 6.83 43.0 µM 1.39E-9 amide catabolism 11 4.27E-12
5 SGTC_274 sirtinol 6.58 40.1 µM 5.25E-9 4 2.43E-11
6 SGTC_1687 st020778 6.36 55.4 µM 1.57E-8 102 1.01E-10
7 SGTC_2040 5100729 6.27 123.0 µM 2.49E-8 8 1.85E-10
8 SGTC_146 3448-8650 6.06 53.1 µM 6.66E-8 NEO1-PIK1 54 6.69E-10
9 SGTC_872 0588-0139 5.89 234.0 µM 1.48E-7 8 1.90E-9
10 SGTC_1868 st057644 5.76 42.7 µM 2.76E-7 10 4.27E-9
11 SGTC_1812 st052057 5.62 4.3 µM 5.20E-7 calcium & mitochondrial duress 7 9.77E-9
12 SGTC_967 1306-0166 5.33 352.0 µM 1.81E-6 8 4.99E-8
13 SGTC_425 3825-7017 5.29 13.1 µM 2.15E-6 10 6.22E-8
14 SGTC_269 exalamide 5.24 29.0 µM 2.65E-6 ergosterol biosynthesis 6 8.16E-8
15 SGTC_1803 st050068 5.20 52.4 µM 3.05E-6 NEO1-PIK1 108 9.82E-8
16 SGTC_528 3492-0019 5.07 172.0 µM 5.21E-6 calcium & mitochondrial duress 153 1.97E-7
17 SGTC_2941 9056145 4.98 11.2 µM 7.61E-6 8 3.23E-7
18 SGTC_536 3852-0578 4.95 10.6 µM 8.43E-6 10 3.69E-7
19 SGTC_3338 9144300 4.59 39.6 µM 3.29E-5 Golgi 16 2.17E-6
20 SGTC_2349 9023730 4.52 187.1 µM 4.35E-5 12 3.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.67E-26 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.165 5.40E-22 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.156 1.22E-19 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.154 2.56E-19 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.153 3.94E-19 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.143 6.72E-17 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.122 1.56E-12 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.118 7.23E-12 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.116 1.62E-11 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.116 1.73E-11 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.114 3.11E-11 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.113 4.46E-11 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.113 5.05E-11 YOR070C GYP1 hom Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
0.106 7.35E-10 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.106 8.50E-10 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p