YPR052C / NHP6A

High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR052C / NHP6A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.50|P-value:3.34E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:3.37|P-value:1.92E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.67|P-value:5.36E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.68|P-value:5.11E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.13|P-value:4.92E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.24|P-value:3.15E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.43|P-value:1.50E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.38|P-value:1.86E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.23|P-value:4.18E-6 ID:SGTC_417|Compound:st075190|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.06|P-value:6.23E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.78|P-value:3.36E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.22|P-value:3.39E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.49|P-value:1.16E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.14|P-value:4.61E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.58|P-value:7.85E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.99|P-value:8.14E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.93|P-value:1.69E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.38|P-value:1.83E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.14|P-value:6.49E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.16|P-value:4.36E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.43|P-value:1.51E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.88|P-value:1.33E-7 ID:SGTC_1653|Compound:st012112|FD-Score:3.05|P-value:6.47E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.12|P-value:5.07E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.09|P-value:8.10E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_2043|Compound:5101342|FD-Score:2.99|P-value:8.10E-4 ID:SGTC_2061|Compound:5245884|FD-Score:2.96|P-value:9.09E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:1.19E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.89|P-value:2.09E-5 ID:SGTC_2133|Compound:5320837|FD-Score:2.97|P-value:8.81E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.18|P-value:3.99E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.24|P-value:3.84E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.85|P-value:2.42E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.76|P-value:3.71E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.06|P-value:8.09E-11 ID:SGTC_2881|Compound:9058953|FD-Score:3.05|P-value:6.44E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.98|P-value:8.51E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.22|P-value:3.38E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.16|P-value:4.31E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.13|P-value:4.89E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-2.94|P-value:9.67E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.22|P-value:3.42E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.50|P-value:3.34E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:3.37|P-value:1.92E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.67|P-value:5.36E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.68|P-value:5.11E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:3.13|P-value:4.92E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.24|P-value:3.15E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.43|P-value:1.50E-6 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.38|P-value:1.86E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.23|P-value:4.18E-6 ID:SGTC_417|Compound:st075190|FD-Score:3.31|P-value:2.43E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.06|P-value:6.23E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.78|P-value:3.36E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.22|P-value:3.39E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.49|P-value:1.16E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.14|P-value:4.61E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.58|P-value:7.85E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.99|P-value:8.14E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.93|P-value:1.69E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.41|P-value:1.60E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.38|P-value:1.83E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.14|P-value:6.49E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.16|P-value:4.36E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.43|P-value:1.51E-6 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.88|P-value:1.33E-7 ID:SGTC_1653|Compound:st012112|FD-Score:3.05|P-value:6.47E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.12|P-value:5.07E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.09|P-value:8.10E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.35|P-value:2.08E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_2043|Compound:5101342|FD-Score:2.99|P-value:8.10E-4 ID:SGTC_2061|Compound:5245884|FD-Score:2.96|P-value:9.09E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.48|P-value:1.19E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.89|P-value:2.09E-5 ID:SGTC_2133|Compound:5320837|FD-Score:2.97|P-value:8.81E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.18|P-value:3.99E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.24|P-value:3.84E-6 ID:SGTC_2350|Compound:9023895|FD-Score:3.85|P-value:2.42E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.76|P-value:3.71E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_2691|Compound:st077356|FD-Score:6.06|P-value:8.09E-11 ID:SGTC_2881|Compound:9058953|FD-Score:3.05|P-value:6.44E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.45|P-value:1.37E-4 ID:SGTC_2967|Compound:9089538|FD-Score:2.98|P-value:8.51E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.22|P-value:3.38E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.16|P-value:4.31E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.13|P-value:4.89E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-2.94|P-value:9.67E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.22|P-value:3.42E-4

Top fitness defect scores for YPR052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2691 st077356 6.06 60.2 µM 8.09E-11 7 6.63E-10
2 SGTC_58 0957-0393 5.50 9.0 µM 3.34E-9 cell wall 243 1.90E-8
3 SGTC_1600 coumarin 106 4.88 71.1 µM 1.33E-7 9 5.27E-7
4 SGTC_319 1348-1596 4.43 45.5 µM 1.50E-6 RSC & ERG11 12 4.70E-6
5 SGTC_1596 piperlongumine 4.43 63.0 µM 1.51E-6 7 4.75E-6
6 SGTC_2225 6654152 4.24 15.4 µM 3.84E-6 11 1.10E-5
7 SGTC_411 enrofloxacin 4.23 100.0 µM 4.18E-6 DNA damage response 8 1.19E-5
8 SGTC_1534 6-azauridine 4.14 81.6 µM 6.49E-6 RNA pol III & RNase P/MRP 19 1.77E-5
9 SGTC_1798 st045719 4.09 61.0 µM 8.10E-6 10 2.16E-5
10 SGTC_1302 1159-0335 3.93 255.0 µM 1.69E-5 14 4.20E-5
11 SGTC_2065 5221596 3.89 34.3 µM 2.09E-5 18 5.10E-5
12 SGTC_2350 9023895 3.85 38.9 µM 2.42E-5 ergosterol biosynthesis 34 5.83E-5
13 SGTC_431 k089-0097 3.78 107.0 µM 3.36E-5 iron homeostasis 53 7.82E-5
14 SGTC_2623 humulene 3.76 100.0 µM 3.71E-5 25 8.56E-5
15 SGTC_190 3970-0790 3.68 3.7 µM 5.11E-5 10 1.14E-4
16 SGTC_169 k015-0017 3.67 16.0 µM 5.36E-5 27 1.19E-4
17 SGTC_1109 tnp00067 3.58 928.3 nM 7.85E-5 24 1.69E-4
18 SGTC_590 k048-0076 3.49 22.4 µM 1.16E-4 RSC & ERG11 19 2.40E-4
19 SGTC_2063 5246145 3.48 200.0 µM 1.19E-4 38 2.46E-4
20 SGTC_2887 9044784 3.45 58.4 µM 1.37E-4 fatty acid desaturase (OLE1) 56 2.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.26E-23 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.171 2.53E-23 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.170 3.53E-23 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.156 8.55E-20 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 8.64E-17 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.128 8.15E-14 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.125 4.04E-13 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.123 7.79E-13 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.123 8.39E-13 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.123 9.35E-13 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.121 1.62E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.121 2.22E-12 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.118 7.27E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.116 1.85E-11 YPR097W YPR097W hom Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.115 2.90E-11 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division