YPR057W / BRR1

snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR057W / BRR1

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:3.95|P-value:2.14E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.15|P-value:4.77E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.02|P-value:6.95E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.97|P-value:8.47E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.86|P-value:3.05E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.73|P-value:5.20E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.02|P-value:7.51E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.29|P-value:6.90E-11 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.67|P-value:3.20E-9 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.18|P-value:4.30E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.83|P-value:3.46E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.00|P-value:8.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.82|P-value:3.54E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.48|P-value:2.04E-11 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.14|P-value:9.34E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:6.87|P-value:1.38E-12 ID:SGTC_1604|Compound:st002052|FD-Score:-3.70|P-value:2.39E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.64|P-value:7.67E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.11|P-value:5.60E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.27|P-value:3.10E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.88|P-value:9.20E-10 ID:SGTC_1648|Compound:st011736|FD-Score:4.20|P-value:6.88E-6 ID:SGTC_1656|Compound:st012921|FD-Score:-4.83|P-value:2.02E-6 ID:SGTC_1658|Compound:st012944|FD-Score:-4.69|P-value:3.82E-6 ID:SGTC_1666|Compound:st014829|FD-Score:4.06|P-value:1.33E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.05|P-value:6.89E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.22|P-value:3.72E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.15|P-value:1.74E-10 ID:SGTC_1853|Compound:st056710|FD-Score:5.03|P-value:1.18E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.14|P-value:4.92E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.65|P-value:7.26E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.11|P-value:1.04E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-5.84|P-value:1.03E-8 ID:SGTC_1974|Compound:st069448|FD-Score:3.59|P-value:9.25E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_2086|Compound:5274770|FD-Score:-3.33|P-value:8.93E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-4.49|P-value:9.75E-6 ID:SGTC_2090|Compound:5301565|FD-Score:4.13|P-value:9.63E-6 ID:SGTC_2095|Compound:5432005|FD-Score:3.62|P-value:8.11E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.61|P-value:9.98E-7 ID:SGTC_2174|Compound:5790901|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.41|P-value:1.10E-7 ID:SGTC_2182|Compound:6325192|FD-Score:-4.77|P-value:2.73E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-6.24|P-value:9.46E-10 ID:SGTC_2185|Compound:6113692|FD-Score:-6.85|P-value:1.94E-11 ID:SGTC_2237|Compound:6667747|FD-Score:-4.01|P-value:7.22E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.58|P-value:9.79E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.45|P-value:1.58E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.16|P-value:5.85E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.86|P-value:1.33E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.21|P-value:3.91E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.53|P-value:8.18E-6 ID:SGTC_2936|Compound:9038235|FD-Score:4.45|P-value:2.23E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.40|P-value:1.94E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.76|P-value:4.62E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.14|P-value:4.99E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.95|P-value:2.14E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.15|P-value:4.77E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.02|P-value:6.95E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.54|P-value:1.11E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.97|P-value:8.47E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.86|P-value:3.05E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.22|P-value:3.70E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.73|P-value:5.20E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.02|P-value:7.51E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.29|P-value:6.90E-11 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.67|P-value:3.20E-9 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.15|P-value:4.74E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.18|P-value:4.30E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.83|P-value:3.46E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.00|P-value:8.04E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.82|P-value:3.54E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:6.48|P-value:2.04E-11 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.14|P-value:9.34E-6 ID:SGTC_1500|Compound:4488-1866|FD-Score:6.87|P-value:1.38E-12 ID:SGTC_1604|Compound:st002052|FD-Score:-3.70|P-value:2.39E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.64|P-value:7.67E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.11|P-value:5.60E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.27|P-value:3.10E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.88|P-value:9.20E-10 ID:SGTC_1648|Compound:st011736|FD-Score:4.20|P-value:6.88E-6 ID:SGTC_1656|Compound:st012921|FD-Score:-4.83|P-value:2.02E-6 ID:SGTC_1658|Compound:st012944|FD-Score:-4.69|P-value:3.82E-6 ID:SGTC_1666|Compound:st014829|FD-Score:4.06|P-value:1.33E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.05|P-value:6.89E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.22|P-value:3.72E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.01|P-value:7.65E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.15|P-value:1.74E-10 ID:SGTC_1853|Compound:st056710|FD-Score:5.03|P-value:1.18E-7 ID:SGTC_1871|Compound:st057448|FD-Score:3.14|P-value:4.92E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.65|P-value:7.26E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.11|P-value:1.04E-5 ID:SGTC_1968|Compound:st069590|FD-Score:-5.84|P-value:1.03E-8 ID:SGTC_1974|Compound:st069448|FD-Score:3.59|P-value:9.25E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.60|P-value:8.81E-5 ID:SGTC_2086|Compound:5274770|FD-Score:-3.33|P-value:8.93E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-4.49|P-value:9.75E-6 ID:SGTC_2090|Compound:5301565|FD-Score:4.13|P-value:9.63E-6 ID:SGTC_2095|Compound:5432005|FD-Score:3.62|P-value:8.11E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.61|P-value:9.98E-7 ID:SGTC_2174|Compound:5790901|FD-Score:4.11|P-value:1.03E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.41|P-value:1.10E-7 ID:SGTC_2182|Compound:6325192|FD-Score:-4.77|P-value:2.73E-6 ID:SGTC_2183|Compound:6420625|FD-Score:-6.24|P-value:9.46E-10 ID:SGTC_2185|Compound:6113692|FD-Score:-6.85|P-value:1.94E-11 ID:SGTC_2237|Compound:6667747|FD-Score:-4.01|P-value:7.22E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.76|P-value:4.64E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.58|P-value:9.79E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.45|P-value:1.58E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.37|P-value:2.18E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.16|P-value:5.85E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.86|P-value:1.33E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.15|P-value:4.78E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.21|P-value:3.91E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-4.53|P-value:8.18E-6 ID:SGTC_2936|Compound:9038235|FD-Score:4.45|P-value:2.23E-6 ID:SGTC_2966|Compound:9084041|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.40|P-value:1.94E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.27|P-value:3.16E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.76|P-value:4.62E-5 ID:SGTC_3214|Compound:9129694|FD-Score:3.14|P-value:4.99E-4

Top fitness defect scores for YPR057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1500 4488-1866 6.87 171.0 µM 1.38E-12 RPP1 & pyrimidine depletion 2 3.25E-12
2 SGTC_1377 2944-0135 6.48 198.0 µM 2.04E-11 calcium & mitochondrial duress 9 4.70E-11
3 SGTC_915 methyl methanesulfonate (MMS) 6.29 110.0 mM 6.90E-11 DNA damage response 8 1.57E-10
4 SGTC_1844 rapamycin 6.15 4.0 nM 1.74E-10 87 3.91E-10
5 SGTC_1647 st011722 5.88 22.4 µM 9.20E-10 2 2.03E-9
6 SGTC_1131 3454-3128 5.67 32.3 µM 3.20E-9 9 6.95E-9
7 SGTC_2606 farnesol 5.16 9.8 µM 5.85E-8 5 1.22E-7
8 SGTC_1853 st056710 5.03 91.2 µM 1.18E-7 amide catabolism 8 2.42E-7
9 SGTC_1374 2889-5571 4.82 141.0 µM 3.54E-7 RSC complex & mRNA processing 19 7.16E-7
10 SGTC_2166 5933061 4.61 31.5 µM 9.98E-7 tubulin folding & SWR complex 23 1.98E-6
11 SGTC_2936 9038235 4.45 15.6 µM 2.23E-6 10 4.35E-6
12 SGTC_1648 st011736 4.20 69.8 µM 6.88E-6 PDR1 11 1.31E-5
13 SGTC_1380 2291-0730 4.14 164.0 µM 9.34E-6 19 1.77E-5
14 SGTC_2090 5301565 4.13 104.5 µM 9.63E-6 TSC3-RPN4 43 1.82E-5
15 SGTC_2174 5790901 4.11 200.0 µM 1.03E-5 tubulin folding & SWR complex 33 1.94E-5
16 SGTC_1965 Pectolinarigenin 4.11 58.4 µM 1.04E-5 RPP1 & pyrimidine depletion 12 1.97E-5
17 SGTC_1666 st014829 4.06 29.0 µM 1.33E-5 calcium & mitochondrial duress 25 2.50E-5
18 SGTC_78 0336-0123 3.95 156.8 µM 2.14E-5 22 3.97E-5
19 SGTC_496 calpeptin 3.86 138.0 µM 3.05E-5 18 5.62E-5
20 SGTC_1226 3909-7979 3.83 35.4 µM 3.46E-5 43 6.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.66E-18 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.148 6.51E-18 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.146 1.88E-17 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.132 1.83E-14 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.125 3.83E-13 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.117 9.56E-12 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.113 5.19E-11 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.108 3.37E-10 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.106 8.02E-10 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.104 1.30E-9 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.104 1.80E-9 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.103 2.02E-9 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.103 2.48E-9 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.100 6.82E-9 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.099 7.72E-9 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus