YPR059C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR059C / YPR059C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.84|P-value:7.58E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.64|P-value:1.68E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:6.07|P-value:9.30E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.17|P-value:9.27E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.47|P-value:5.03E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:5.40|P-value:4.71E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:5.07|P-value:2.70E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:4.22|P-value:1.58E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.23|P-value:7.52E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.42|P-value:3.79E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.97|P-value:4.58E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:7.16|P-value:6.11E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.32|P-value:3.85E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:7.11|P-value:9.22E-13 ID:SGTC_438|Compound:sphingosine|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.73|P-value:1.47E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:4.36|P-value:8.39E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:4.11|P-value:2.58E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.69|P-value:9.39E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.85|P-value:7.57E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.89|P-value:6.35E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.84|P-value:3.72E-9 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.23|P-value:7.49E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.45|P-value:5.68E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.59|P-value:2.88E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.50|P-value:2.92E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:7.82|P-value:4.49E-15 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.43|P-value:6.16E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.43|P-value:3.66E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.54|P-value:3.62E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.46|P-value:3.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.34|P-value:6.37E-8 ID:SGTC_1952|Compound:st077036|FD-Score:4.26|P-value:1.34E-5 ID:SGTC_1957|Compound:st077035|FD-Score:4.02|P-value:3.62E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.97|P-value:2.95E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.55|P-value:3.46E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.39|P-value:4.22E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.59|P-value:2.96E-6 ID:SGTC_2142|Compound:5622915|FD-Score:-3.19|P-value:6.08E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.31|P-value:3.96E-4 ID:SGTC_2166|Compound:5933061|FD-Score:5.63|P-value:1.25E-8 ID:SGTC_2237|Compound:6667747|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.11|P-value:7.96E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.78|P-value:1.16E-6 ID:SGTC_2318|Compound:6029776|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.74|P-value:1.40E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.88|P-value:4.34E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.44|P-value:3.51E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.24|P-value:1.41E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.44|P-value:3.56E-4 ID:SGTC_2851|Compound:9015922|FD-Score:7.16|P-value:6.09E-13 ID:SGTC_2936|Compound:9038235|FD-Score:3.46|P-value:3.36E-4 ID:SGTC_3057|Compound:9095946|FD-Score:5.56|P-value:1.87E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.26|P-value:6.74E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.86|P-value:7.71E-7 ID:SGTC_9|Compound:0092-0002|FD-Score:3.84|P-value:7.58E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.64|P-value:1.68E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:6.07|P-value:9.30E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.17|P-value:9.27E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.47|P-value:5.03E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:5.40|P-value:4.71E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:5.07|P-value:2.70E-7 ID:SGTC_113|Compound:0099-0221|FD-Score:4.22|P-value:1.58E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.23|P-value:7.52E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.42|P-value:3.79E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.97|P-value:4.58E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:7.16|P-value:6.11E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.32|P-value:3.85E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:7.11|P-value:9.22E-13 ID:SGTC_438|Compound:sphingosine|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.73|P-value:1.47E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:4.36|P-value:8.39E-6 ID:SGTC_638|Compound:3970-0837|FD-Score:4.11|P-value:2.58E-5 ID:SGTC_653|Compound:0203-0016|FD-Score:-3.69|P-value:9.39E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.85|P-value:7.57E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.89|P-value:6.35E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.84|P-value:3.72E-9 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.23|P-value:7.49E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:4.45|P-value:5.68E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.59|P-value:2.88E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.50|P-value:2.92E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:7.82|P-value:4.49E-15 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.43|P-value:6.16E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.43|P-value:3.66E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.54|P-value:3.62E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.46|P-value:3.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.34|P-value:6.37E-8 ID:SGTC_1952|Compound:st077036|FD-Score:4.26|P-value:1.34E-5 ID:SGTC_1957|Compound:st077035|FD-Score:4.02|P-value:3.62E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.97|P-value:2.95E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.55|P-value:3.46E-6 ID:SGTC_1987|Compound:st072290|FD-Score:3.68|P-value:1.45E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.39|P-value:4.22E-4 ID:SGTC_2114|Compound:5491910|FD-Score:4.59|P-value:2.96E-6 ID:SGTC_2142|Compound:5622915|FD-Score:-3.19|P-value:6.08E-4 ID:SGTC_2164|Compound:5685496|FD-Score:-3.31|P-value:3.96E-4 ID:SGTC_2166|Compound:5933061|FD-Score:5.63|P-value:1.25E-8 ID:SGTC_2237|Compound:6667747|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.11|P-value:7.96E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.78|P-value:1.16E-6 ID:SGTC_2318|Compound:6029776|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.74|P-value:1.40E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.88|P-value:4.34E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.44|P-value:3.51E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.24|P-value:1.41E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.44|P-value:3.56E-4 ID:SGTC_2851|Compound:9015922|FD-Score:7.16|P-value:6.09E-13 ID:SGTC_2936|Compound:9038235|FD-Score:3.46|P-value:3.36E-4 ID:SGTC_3057|Compound:9095946|FD-Score:5.56|P-value:1.87E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.26|P-value:6.74E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.74|P-value:1.13E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.86|P-value:7.71E-7

Top fitness defect scores for YPR059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1470 k295-0292 7.82 231.0 µM 4.49E-15 2 2.73E-15
2 SGTC_2851 9015922 7.16 71.4 µM 6.09E-13 5 3.89E-13
3 SGTC_184 1494-0393 7.16 24.7 µM 6.11E-13 11 3.91E-13
4 SGTC_428 3448-4153 7.11 16.5 µM 9.22E-13 TSC3-RPN4 2 5.92E-13
5 SGTC_42 0133-0086 6.07 60.6 µM 9.30E-10 3 6.41E-10
6 SGTC_1107 amlodipine 5.84 47.0 µM 3.72E-9 5 2.61E-9
7 SGTC_2166 5933061 5.63 31.5 µM 1.25E-8 tubulin folding & SWR complex 16 8.92E-9
8 SGTC_3057 9095946 5.56 49.5 µM 1.87E-8 Golgi 4 1.33E-8
9 SGTC_66 0109-0187 5.40 42.4 µM 4.71E-8 17 3.40E-8
10 SGTC_1926 methyl fluorone black 5.34 53.6 µM 6.37E-8 DNA intercalators 27 4.62E-8
11 SGTC_78 0336-0123 5.07 156.8 µM 2.70E-7 12 1.99E-7
12 SGTC_145 3737-0113 4.97 38.4 µM 4.58E-7 DNA intercalators 45 3.40E-7
13 SGTC_3264 9137442 4.86 49.5 µM 7.71E-7 6 5.76E-7
14 SGTC_2317 5986382 4.78 200.0 µM 1.16E-6 3 8.73E-7
15 SGTC_2363 9053361 4.74 176.0 µM 1.40E-6 Golgi 19 1.05E-6
16 SGTC_471 1-acyl-paf 4.73 4.0 µM 1.47E-6 DNA intercalators 17 1.11E-6
17 SGTC_1459 k035-0031 4.59 35.7 µM 2.88E-6 DNA intercalators 12 2.19E-6
18 SGTC_2114 5491910 4.59 81.2 µM 2.96E-6 4 2.25E-6
19 SGTC_1970 st070122 4.55 35.8 µM 3.46E-6 TSC3-RPN4 19 2.63E-6
20 SGTC_1493 4348-0038 4.54 111.0 µM 3.62E-6 RSC complex & mRNA processing 13 2.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.71E-32 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.196 2.00E-30 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.186 1.47E-27 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.183 1.61E-26 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.169 6.35E-23 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.157 6.87E-20 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.156 1.31E-19 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.153 4.80E-19 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.151 1.47E-18 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 8.12E-18 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.146 1.66E-17 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.144 6.74E-17 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.143 8.42E-17 YML047W-A_d YML047W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.76E-16 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.140 4.33E-16 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes