YPR060C / ARO7

Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR060C / ARO7

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.08|P-value:8.83E-6 ID:SGTC_8|Compound:0354-0001|FD-Score:4.57|P-value:5.64E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:5.01|P-value:1.14E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:4.42|P-value:9.46E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:4.01|P-value:3.69E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.89|P-value:1.79E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:12.20|P-value:9.98E-26 ID:SGTC_52|Compound:0329-0193|FD-Score:3.75|P-value:8.11E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.48|P-value:7.80E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:6.76|P-value:4.94E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:4.82|P-value:2.31E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:5.89|P-value:3.02E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:4.82|P-value:2.36E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:8.02|P-value:4.70E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:6.16|P-value:8.99E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:3.70|P-value:9.34E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.72|P-value:8.85E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:6.67|P-value:7.83E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:4.81|P-value:2.45E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.60|P-value:1.09E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:5.75|P-value:5.64E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:4.57|P-value:5.63E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:9.53|P-value:2.59E-16 ID:SGTC_206|Compound:4546-0025|FD-Score:4.61|P-value:5.04E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:7.74|P-value:2.44E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.76|P-value:5.31E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.69|P-value:9.70E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.84|P-value:2.14E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.98|P-value:3.99E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.65|P-value:7.32E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:8.52|P-value:2.22E-13 ID:SGTC_315|Compound:k915-0449|FD-Score:7.21|P-value:4.81E-10 ID:SGTC_367|Compound:0335-0881|FD-Score:7.50|P-value:9.72E-11 ID:SGTC_394|Compound:menadione|FD-Score:7.72|P-value:2.78E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.62|P-value:4.72E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.69|P-value:9.56E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.73|P-value:8.51E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.19|P-value:5.68E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:3.93|P-value:4.73E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.51|P-value:1.57E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:7.45|P-value:1.26E-10 ID:SGTC_579|Compound:4491-1009|FD-Score:3.95|P-value:4.38E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:10.40|P-value:4.61E-19 ID:SGTC_835|Compound:0312-0010|FD-Score:6.72|P-value:5.92E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.18|P-value:5.82E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.19|P-value:2.07E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.23|P-value:1.79E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.32|P-value:2.57E-10 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.69|P-value:9.59E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.58|P-value:1.16E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.98|P-value:1.30E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.89|P-value:5.22E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.75|P-value:5.74E-7 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.69|P-value:3.74E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:4.48|P-value:7.83E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.58|P-value:3.35E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.87|P-value:1.98E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:7.27E-4 ID:SGTC_1656|Compound:st012921|FD-Score:15.70|P-value:2.73E-41 ID:SGTC_1696|Compound:st025591|FD-Score:4.50|P-value:7.28E-5 ID:SGTC_1699|Compound:st031318|FD-Score:6.56|P-value:1.32E-8 ID:SGTC_1726|Compound:st035556|FD-Score:3.75|P-value:7.99E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.71|P-value:9.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:12.90|P-value:1.35E-28 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.11|P-value:2.70E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.69|P-value:9.43E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.43|P-value:9.17E-5 ID:SGTC_2132|Compound:5317594|FD-Score:11.00|P-value:3.60E-21 ID:SGTC_2213|Compound:7173844|FD-Score:5.30|P-value:3.69E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.22|P-value:1.85E-4 ID:SGTC_2254|Compound:7938975|FD-Score:7.29|P-value:2.98E-10 ID:SGTC_2322|Compound:7413319|FD-Score:7.70|P-value:3.12E-11 ID:SGTC_2442|Compound:5158906|FD-Score:3.73|P-value:8.43E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:10.00|P-value:7.19E-18 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.39|P-value:3.10E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:6.09|P-value:1.22E-7 ID:SGTC_2618|Compound:avocadyne|FD-Score:8.45|P-value:3.42E-13 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.28|P-value:2.32E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.16|P-value:2.25E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.33|P-value:1.32E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.89|P-value:1.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:9.68E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.85|P-value:6.04E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.34|P-value:3.13E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.26|P-value:1.66E-4 ID:SGTC_2907|Compound:7721985|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_2932|Compound:9016711|FD-Score:11.30|P-value:2.39E-22 ID:SGTC_2976|Compound:9009005|FD-Score:12.70|P-value:1.85E-27 ID:SGTC_3018|Compound:9082602|FD-Score:4.48|P-value:7.79E-5 ID:SGTC_3046|Compound:9092212|FD-Score:12.50|P-value:1.07E-26 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.66|P-value:3.84E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.46|P-value:1.92E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.50|P-value:3.23E-16 ID:SGTC_3073|Compound:9114972|FD-Score:-3.62|P-value:7.89E-4 ID:SGTC_3101|Compound:9120531|FD-Score:9.36|P-value:8.34E-16 ID:SGTC_3217|Compound:9129673|FD-Score:4.93|P-value:1.54E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.97|P-value:4.09E-4 ID:SGTC_3303|Compound:9125618|FD-Score:16.10|P-value:4.78E-43 ID:SGTC_3308|Compound:9128332|FD-Score:5.60|P-value:1.06E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:5.08|P-value:8.83E-6 ID:SGTC_8|Compound:0354-0001|FD-Score:4.57|P-value:5.64E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:5.01|P-value:1.14E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:4.42|P-value:9.46E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:4.01|P-value:3.69E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.89|P-value:1.79E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:12.20|P-value:9.98E-26 ID:SGTC_52|Compound:0329-0193|FD-Score:3.75|P-value:8.11E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.48|P-value:7.80E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:6.76|P-value:4.94E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:4.82|P-value:2.31E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:5.89|P-value:3.02E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:4.82|P-value:2.36E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:8.02|P-value:4.70E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:6.16|P-value:8.99E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:3.70|P-value:9.34E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.72|P-value:8.85E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:6.67|P-value:7.83E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:4.81|P-value:2.45E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:6.60|P-value:1.09E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:5.75|P-value:5.64E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:4.57|P-value:5.63E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:9.53|P-value:2.59E-16 ID:SGTC_206|Compound:4546-0025|FD-Score:4.61|P-value:5.04E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:7.74|P-value:2.44E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:5.76|P-value:5.31E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.69|P-value:9.70E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.84|P-value:2.14E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.98|P-value:3.99E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.65|P-value:7.32E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:8.52|P-value:2.22E-13 ID:SGTC_315|Compound:k915-0449|FD-Score:7.21|P-value:4.81E-10 ID:SGTC_367|Compound:0335-0881|FD-Score:7.50|P-value:9.72E-11 ID:SGTC_394|Compound:menadione|FD-Score:7.72|P-value:2.78E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.62|P-value:4.72E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.69|P-value:9.56E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.73|P-value:8.51E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:5.19|P-value:5.68E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:3.93|P-value:4.73E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.51|P-value:1.57E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:7.45|P-value:1.26E-10 ID:SGTC_579|Compound:4491-1009|FD-Score:3.95|P-value:4.38E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:10.40|P-value:4.61E-19 ID:SGTC_835|Compound:0312-0010|FD-Score:6.72|P-value:5.92E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.18|P-value:5.82E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:4.19|P-value:2.07E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.23|P-value:1.79E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.32|P-value:2.57E-10 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.69|P-value:9.59E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.58|P-value:1.16E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.98|P-value:1.30E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.89|P-value:5.22E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.75|P-value:5.74E-7 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.33|P-value:1.30E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.69|P-value:3.74E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:4.48|P-value:7.83E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-4.58|P-value:3.35E-5 ID:SGTC_1625|Compound:st003711|FD-Score:4.87|P-value:1.98E-5 ID:SGTC_1637|Compound:st007924|FD-Score:3.78|P-value:7.27E-4 ID:SGTC_1656|Compound:st012921|FD-Score:15.70|P-value:2.73E-41 ID:SGTC_1696|Compound:st025591|FD-Score:4.50|P-value:7.28E-5 ID:SGTC_1699|Compound:st031318|FD-Score:6.56|P-value:1.32E-8 ID:SGTC_1726|Compound:st035556|FD-Score:3.75|P-value:7.99E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.71|P-value:9.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:12.90|P-value:1.35E-28 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.11|P-value:2.70E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.69|P-value:9.43E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.43|P-value:9.17E-5 ID:SGTC_2132|Compound:5317594|FD-Score:11.00|P-value:3.60E-21 ID:SGTC_2213|Compound:7173844|FD-Score:5.30|P-value:3.69E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.22|P-value:1.85E-4 ID:SGTC_2254|Compound:7938975|FD-Score:7.29|P-value:2.98E-10 ID:SGTC_2322|Compound:7413319|FD-Score:7.70|P-value:3.12E-11 ID:SGTC_2442|Compound:5158906|FD-Score:3.73|P-value:8.43E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:10.00|P-value:7.19E-18 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.39|P-value:3.10E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:6.09|P-value:1.22E-7 ID:SGTC_2618|Compound:avocadyne|FD-Score:8.45|P-value:3.42E-13 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.28|P-value:2.32E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.16|P-value:2.25E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.33|P-value:1.32E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.89|P-value:1.83E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.42|P-value:9.68E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:3.85|P-value:6.04E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.34|P-value:3.13E-6 ID:SGTC_2789|Compound:5281112|FD-Score:4.26|P-value:1.66E-4 ID:SGTC_2907|Compound:7721985|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_2932|Compound:9016711|FD-Score:11.30|P-value:2.39E-22 ID:SGTC_2976|Compound:9009005|FD-Score:12.70|P-value:1.85E-27 ID:SGTC_3018|Compound:9082602|FD-Score:4.48|P-value:7.79E-5 ID:SGTC_3046|Compound:9092212|FD-Score:12.50|P-value:1.07E-26 ID:SGTC_3059|Compound:1327-0034|FD-Score:7.66|P-value:3.84E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.46|P-value:1.92E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:9.50|P-value:3.23E-16 ID:SGTC_3073|Compound:9114972|FD-Score:-3.62|P-value:7.89E-4 ID:SGTC_3101|Compound:9120531|FD-Score:9.36|P-value:8.34E-16 ID:SGTC_3217|Compound:9129673|FD-Score:4.93|P-value:1.54E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.97|P-value:4.09E-4 ID:SGTC_3303|Compound:9125618|FD-Score:16.10|P-value:4.78E-43 ID:SGTC_3308|Compound:9128332|FD-Score:5.60|P-value:1.06E-6

Top fitness defect scores for YPR060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3303 9125618 16.10 40.6 µM 4.78E-43 1 2.33E-58
2 SGTC_1656 st012921 15.70 11.0 µM 2.73E-41 3 5.84E-56
3 SGTC_1750 st081859 12.90 2.4 µM 1.35E-28 endomembrane recycling 28 1.29E-38
4 SGTC_2976 9009005 12.70 19.5 µM 1.85E-27 5 4.61E-37
5 SGTC_3046 9092212 12.50 49.5 µM 1.07E-26 1 5.09E-36
6 SGTC_46 0329-0187a 12.20 2.2 µM 9.98E-26 5 1.07E-34
7 SGTC_2932 9016711 11.30 44.5 µM 2.39E-22 5 4.46E-30
8 SGTC_2132 5317594 11.00 122.7 µM 3.60E-21 SWF1 & branched chain AA biosynthesis 4 1.81E-28
9 SGTC_581 0958-0271 10.40 211.0 µM 4.61E-19 3 1.37E-25
10 SGTC_2580 diallyl disulphide 10.00 81.4 µM 7.19E-18 1 5.87E-24
11 SGTC_195 4234-0266 9.53 16.6 µM 2.59E-16 3 7.84E-22
12 SGTC_3063 1327-0034 9.50 4.0 µM 3.23E-16 9 1.06E-21
13 SGTC_3101 9120531 9.36 49.5 µM 8.34E-16 1 3.88E-21
14 SGTC_308 4092-1169 8.52 104.0 µM 2.22E-13 plasma membrane duress 5 7.98E-18
15 SGTC_2618 avocadyne 8.45 43.4 µM 3.42E-13 13 1.45E-17
16 SGTC_84 0443-0269 8.02 128.8 µM 4.70E-12 1 5.19E-16
17 SGTC_207 4185-0010 7.74 4.5 µM 2.44E-11 endomembrane recycling 28 4.91E-15
18 SGTC_394 menadione 7.72 8.3 µM 2.78E-11 superoxide 6 5.87E-15
19 SGTC_2322 7413319 7.70 38.2 µM 3.12E-11 ERAD & cell cycle 38 6.90E-15
20 SGTC_3059 1327-0034 7.66 3.0 µM 3.84E-11 19 9.13E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 1.07E-135 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.394 1.23E-124 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.284 1.54E-63 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.267 6.12E-56 YHL011C PRS3 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.236 1.38E-43 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.226 4.09E-40 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.217 5.31E-37 YPR153W YPR153W hom Putative protein of unknown function
0.207 6.95E-34 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.206 1.96E-33 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.204 5.18E-33 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.199 2.09E-31 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.188 6.79E-28 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.184 5.38E-27 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.184 6.65E-27 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.178 2.42E-25 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress